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Associations of heart rate, cognitive function, and retinal vascular calibers with glomerular filtration rate (GFR) and age-related GFR decline in a healthy general population
(Doctoral thesis; Doktorgradsavhandling, 2025-04-07)Kronisk nyresykdom er en økende global helseutfordring, mye som følge av en aldrende befolkning samt bedre behandlinger av kroniske sykdommer som øker overlevelsesraten. Nyrefunksjonen, vurdert ved glomerulær filtrasjonsrate (GFR), avtar naturlig med alderen, men dette tas imidlertid ikke hensyn til i definisjonen av kronisk nyresykdom. Dette kan føre til overdiagnostisering hos personer med fysiologisk ... -
Socioeconomic and geographic variation in adjuvant chemotherapy among elderly patients with stage III colon cancer in Norway – a national register-based cohort study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-12-17)Background About half of the patients diagnosed with colon cancer are 70 years or older. Standard treatment for stage III colon cancer is major surgical resection followed by adjuvant chemotherapy (ACT). Norwegian guidelines recommend initiation of ACT within 6 weeks after resection. Objective This study investigated socioeconomic and geographic variation in the recommended provision of ACT to ... -
Søsken i skyggen av sykdom. Helse og læring gjennom felleslesning
(Chapter; Bokkapittel, 2024) -
An Investigation of the Barriers to Care of Adult Patients With a Tracheostomy in Intensive Care Units and General Wards: Secondary Analysis of Qualitative Interview Data
(Journal article; Tidsskriftartikkel, 2024-12-23)<p><i>Aims and Objectives</i> To investigate the barriers experienced by intensive care nurses and registered nurses and to provide optimal nursing for adult patients with a temporary tracheostomy in intensive care and general wards. <p><i>Background</i> Tracheostomy is widely used in intensive care units, around 20% of intensive care unit patients undergo tracheostomy insertions and expect high ... -
Cross-Cultural Comparison of the Strengths and Difficulties Self-Report Questionnaire in 12 Asian and European Countries
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-10-08)Objective - The self-report Strengths and Difficulties Questionnaire (SDQ) is widely used globally; hence, the validity of the intergroup comparisons is essential. This study examined the structure of the self-report SDQ in a large multinational adolescent sample, tested its measurement invariance across genders and countries, and compared youth mental health in 12 European and Asian countries.<p> ... -
Vitamin D status in an adolescent Arctic population: Results from the Fit Futures study
(Doctoral thesis; Doktorgradsavhandling, 2025-03-27)There has been limited knowledge about the vitamin D status in Norwegian adolescents. Residing at high latitude, North Norwegian adolescents are at risk of vitamin D deficiency. The population-based longitudinal study Fit Futures (69°N) provided a unique opportunity to examine vitamin D prevalence among 16- and 18-year-olds and report lifestyle habits predictive of vitamin D levels. Vitamin D ... -
Måleegenskaper ved den norske versjonen av Hopkins Symptom Checklist-5 (HSCL-5)
(Journal article; Tidsskriftartikkel; Peer reviewed, 2025-03-05)Beskrivelse: Hopkins Symptom Checklist-5 (HSCL-5) er et kortfattet måleverktøy for psykiske plager. HSCL-5 består av fem spørreledd som kartlegger respondentens angst- og depresjonssymptomer i løpet av de to siste ukene. Instrumentet ble utviklet av Tambs og Moum som en kortere versjon av HSCL-25. HSCL-5 er i utgangspunktet ment for forskere som vil måle symptomer hos voksne, men måleverktøyet har ... -
Why is it so difficult to understand why we don’t understand human systemic lupus erythematosus? Contemplating facts, conflicts, and impact of “the causality cascade paradigm”
(Journal article; Tidsskriftartikkel; Peer reviewed, 2025-01-28)n attempts to understand systemic lupus erythematosus (SLE), we find ourselves in the intellectual cross-point between nosology, pathogenicity-oriented science, philosophy, empiricism, and qualified conjectures. A vital consequence in science theory is that scientific hypotheses that are not critically investigated are in danger of being transformed into scientific dogmas. This statement has ... -
Immunological signatures from irradiated cancer-associated fibroblasts
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-09-06)Introduction: Cancer-associated fibroblasts (CAFs) are abundant and influential elements of the tumor microenvironment (TME), giving support to tumor development in multiple ways. Among other mechanisms, CAFs are important regulators of immunological processes occurring in tumors. However, CAF-mediated tumor immunomodulation in the context of radiotherapy remains poorly understood. In this study, ... -
Neonatal Ultrasound and Radiographic Markers of Hip Dysplasia in Young Adults
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-03-19)OBJECTIVES - To examine radiologic outcomes at skeletal maturity of sonographically normal, immature, mildly, and severely dysplastic newborn hips.<p> <p>METHODS - During 1988 to 1990, 11 925 newborns were enrolled in a randomized controlled trial examining screening strategies for developmental hip dysplasia. In total, 4469 were invited to clinical and radiologic follow-up 18 years later, of ... -
General and abdominal adiposity and hypertension in eight world regions: a pooled analysis of 837 population-based studies with 7·5 million participants
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-08-29)Background - Adiposity can be measured using BMI (which is based on weight and height) as well as indices of abdominal adiposity. We examined the association between BMI and waist-to-height ratio (WHtR) within and across populations of different world regions and quantified how well these two metrics discriminate between people with and without hypertension.<p> <p>Methods - We used data from ... -
Exploring Interaction between Genetically Predicted Body Mass Index and Serum 25-Hydroxyvitamin D Levels on the Odds for Psoriasis in UK Biobank and the HUNT Study: A Factorial Mendelian Randomization Study
(Journal article; Tidsskriftartikkel, 2025-12-03)Mendelian randomisation (MR) studies show that higher body mass index (BMI) and lower 25-hydroxyvitamin D (25[OH]D) increase psoriasis risk. The combined effect of these factors has not been explored using factorial MR. Using cross-sectional data from UK Biobank (UKB, n=398 404) and the Trøndelag Health Study (HUNT, n=86 648), we calculated polygenic risk scores for BMI and 25(OH)D to estimate odds ... -
Sensorineural hearing impairment among preterm children: a Norwegian population-based study
(Journal article; Tidsskriftartikkel, 2024-06-05)<p><i>Objective</i> To investigate the risk for sensorineural hearing impairment (SNHI) in preterm infants, and to what extent the risk is attributed to perinatal morbidities and therapies. <p><i>Design</i> Population-based cohort study using data from several nationwide registries. <p><i>Setting</i> Norwegian birth cohort 1999–2014, with data on SNHI until 2019. <p><i>Participants</i> 60 023 ... -
Impact of Gut Microbiome Modulating Interventions on Fecal Metabolome of Infants: A Systematic Review and Quality Assessment
(Journal article; Tidsskriftartikkel; Peer reviewed, 2025-02-27)The development of the gut microbiome in infancy is a vulnerable process that may be perturbed by antibiotics or supported by probiotics. Although effects of these “biotics” have been well-studied through DNA sequencing, it remains unclear how the resulting compositional changes affect the microbiome metabolic functions. Additionally, limits in method standardization require careful quality assessment ... -
Circulating endogenous sex steroids and risk of differentiated thyroid carcinoma in men and women
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-02-15)Thyroid cancer (TC) is substantially more common in women than in men, pointing to a possible role of sex steroid hormones. We investigated the association between circulating sex steroid hormones, sex hormone binding globulin (SHBG) and the risk of differentiated TC in men and women within the European Prospective Investigation into Cancer and nutrition (EPIC) cohort. During follow-up, we identified ... -
Evaluating the efficacy of endotracheal and intranasal epinephrine administration in severely asphyxic bradycardic newborn lambs: a randomised preclinical study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-09-04)Objective - Intravenous epinephrine administration is preferred during neonatal resuscitation, but may not always be rapidly administered due to lack of equipment or trained staff. We aimed to compare the time to return of spontaneous circulation (ROSC) and post-ROSC haemodynamics between intravenous, endotracheal (ET) and intranasal (IN) epinephrine in severely asphyxic, bradycardic newborn ... -
Deep learning-assisted two-dimensional transperineal ultrasound for analyzing bladder neck motion in women with stress urinary incontinence
(Journal article; Tidsskriftartikkel; Peer reviewed, 2025-07-18)Background - No universally recognized transperineal ultrasound parameters are available for evaluating stress urinary incontinence. The information captured by commonly used perineal ultrasound parameters is limited and insufficient for a comprehensive assessment of stress urinary incontinence. Although bladder neck motion plays a major role in stress urinary incontinence, objective and visual ... -
Scandinavian healthcare professionals’ perceptions of rehabilitation practices in the intensive care unit. A cross-sectional survey
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-10-10)Objective - To describe healthcare professionals’ perception of current early rehabilitation practices and their preconditions, focusing on functional and cognitive stimulation facilitated by nurses and other healthcare professionals in Scandinavian intensive care units (ICUs).<p> <p>Design - Cross-sectional electronic survey administered to healthcare professionals. The survey was developed in ... -
Barneperspektivsamtalen+, et familiefokusert verktøy for brukermedvirkning
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-11-26)Når en forelder har en psykisk sykdom, påvirkes hele familien. Pårørendes medvirkning er viktig for å gi god og riktig hjelp til disse familiene. Det er lovpålagt å gi informasjon og støtte til barn som er pårørende, noe som er essensielt for å trygge barna. Barna må få mulighet til å fortelle helsepersonell hvordan de opplever situasjonen, slik at helsepersonell kan tilrettelegge for å støtte og ... -
Exploring surgical infection prediction: A comparative study of established risk indexes and a novel model
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-02-05)Background - Surgical site infections are a major health problem that deteriorates the patients’ health and increases health care costs. A reliable method to identify patients with modifiable risk of surgical site infection is necessary to reduce the incidence of them but data are limited. Hence the objective is to assess the predictive validity of a logistic regression model compared to risk indexes ...
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