Blar i tittel Doktorgradsavhandlinger (Helsefak)

Viser treff 526-545 av 697

    • Resuscitate the heart and remember the brain. A prospective observational study of cognitive outcome after Out-of-Hospital Cardiac arrest 

      Ørbo, Marte Christine (Doctoral thesis; Doktorgradsavhandling, 2016-06-03)
      Cognitive outcome after out-of-hospital cardiac arrest Aim: To investigate long-term cognitive outcomes after survival from Out-of-Hospital Cardiac Arrest (OHCA) with neuropsychological assessment methods. Background: OHCA may cause cognitive impairments and functional disability due to hypoxic-ischemic brain injury. Methods: Cognitive functions, health-related quality of life and affective symptoms ...

    • Retinal vascular calibres: Risk factors and methodological aspects of retinal vascular imaging. The Tromsø Eye Study – a part of the Tromsø Study. 

      Hanno, Therese von (Doctoral thesis; Doktorgradsavhandling, 2014-02-06)
      Cardiovascular disease is a major cause of death and morbidity in developed countries. The eye offers a unique window to the study of the microvasculature in vivo, which has been less investigated than the macrovasculature. We wanted to investigate the relationship between the traditional cardiovascular risk factors and retinal vascular calibres. Further, iron is a proposed cardiovascular risk factor ...

    • Retinopathy with and without diabetes: Risk factors and visual impairment. 

      Bertelsen, Geir (Doctoral thesis; Doktorgradsavhandling, 2013-03-22)
      Diabetic retinopathy is a well-known complication of diabetes and a major cause of visual impairment and blindness in developed countries. We explored visual impairment and diabetic retinopathy among participants with diabetes in the Tromsø Eye Study. The prevalence of visual impairment (corrected Snellen visual acuity < 20/40) was 4.1% in the better-seeing eye. We found no legally blind participants. ...

    • Retro-trochanteric sciatica-like pain : in-depth analyses of clinical symptoms, treatment options, histological and ultra structural findings in tendon biopsies 

      Meknas, M. Khaled (Doctoral thesis; Doktorgradsavhandling, 2010-05-28)
      I vår praksis ved sykehuset møtte vi stadig pasienter med uforklarlige smerter i hofte og lår, og utstråling til legg. Siden en muskel (piriformis) tidligere hadde vært beskrevet å klemme mot ischiasnerven, ville vi gjøre mer systematiske studier av dette tidligere beskrevne syndromet. Ved operasjon fant vi at en annen muskel (obturatorius internus) klemte over ischiasnerven. Oppfølgningsstudier har ...

    • Risk and protective factors associated with internalizing symptoms in Sami and non-Sami adolescents in Arctic Norway 

      Bals, Margrethe (Doctoral thesis; Doktorgradsavhandling, 2011-01-14)
      This thesis examined common and culture-specific risk and protective factors for internalizing (anxiety and depression) symptoms in Sami and non-Sami adolescents. This is a cross-sectional study, and the data are from The Norwegian Arctic Adolescent Health Study which was conducted among 10th graders in junior high schools in Arctic Norway in 2003-2005. The sample consisted of 4,449 adolescents, of ...

    • Risk Factors and Triggers of Venous Thromboembolism in Patients with Myocardial Infarction 

      Sejrup, Joakim Knutsen (Doctoral thesis; Doktorgradsavhandling, 2022-06-17)
      <p>During the past decades, extensive data from the general population have revealed that patients with acute myocardial infarction (MI) are at increased risk of venous thromboembolism (VTE, i.e., deep vein thrombosis [DVT] and pulmonary embolism [PE]). The risk is highest in the initial 0-6 months following an acute MI, and declines rapidly thereafter. The explanation for the observed association ...

    • Risk factors of adverse pregnancy outcomes: opportunities and perspectives of a birth registry-based study 

      Usynina, Anna Alexandrovna (Doctoral thesis; Doktorgradsavhandling, 2017-02-08)
      Background: Preterm birth, perinatal death, and birth of babies small for gestational age are amongst common adverse pregnancy outcomes. Maternal lifestyle, mothers’ health status before and during pregnancy, previous adverse pregnancy outcomes as well as socio-demographic factors all influence perinatal mortality, prematurity, and small for gestational age birth. To date, despite many studies of ...

    • Road traffic crashes in Arkhangelsk, Russia in 2005-2010 

      Kudryavtsev, Alexander Valerievich (Doctoral thesis; Doktorgradsavhandling, 2013-01-11)
      The research project “Road traffic crashes in Arkhangelsk, Russia in 2005-2010” is the basis for my PhD dissertation. It addresses traffic safety – a major public health concern in Russia. The dissertation describes recent trends and determinants of traffic safety in Arkhangelsk and will contribute a part of the evidence basis for planning local road safety measures in future. The Department of ...

    • Role of CALCOCO1 in scaling down endoplasmic reticulum and Golgi by autophagy 

      Nthiga, Thaddaeus Mutugi (Doctoral thesis; Doktorgradsavhandling, 2020-02-20)
      Endoplasmic reticulum (ER) and Golgi apparatus are key organelles in the synthesis, modification and trafficking of proteins in eukaryotic cells. In response to stress stimuli such as nutrients deprivation, accumulation of misfolded proteins or exposure to chemicals, the ER increases in size through increased synthesis of its components to counteract the stress. Similarly, Golgi response to stress ...

    • The role of complement and Toll-like receptors in thromboinflammation 

      Landsem, Anne (Doctoral thesis; Doktorgradsavhandling, 2019-05-23)
      Sepsis fra bakterier er en alvorlig tilstand som årlig krever mange liv. Selv om immunsystemet og det hemostatiske system samarbeider for å bekjempe bakterieinfeksjoner, kan dette i noen tilfelle skyte over mål. Derfor har vi i denne studien undersøkt om bakterieindusert aktivering av koagulasjon og inflammasjon reduseres av en dobbelthemming av komplementsystemet og toll-like reseptorer (TLR). Det ...

    • Role of Extracellular Vesicles in the Pathogenesis of Venous Thromboembolism 

      Jamaly, Simin (Doctoral thesis; Doktorgradsavhandling, 2018-06-13)
      Venous thromboembolism (VTE) is a common disease with an incidence of 1–2 per 1000 individuals. VTE is a collective term for deep vein thrombosis and pulmonary embolism. Extracellular vesicles (EVs) are lipid-membrane-bound spherical vesicles that bud off from the cells upon activation and apoptosis. Their size varies between 30 nm and 1 μm. Recent advances in experimental and observational studies ...

    • The role of inflammatory pathways in neuroblastoma tumorigenesis 

      Snapkov, Igor (Doctoral thesis; Doktorgradsavhandling, 2016-09-23)
      Neuroblastoma er en type nervecellekreft hos barn. Den har en svært kompleks biologisk heterogenisitet og er i noen tilfeller resistent mot cellegift. Den aggressive varianten av neuroblastoma er vanskelig å behandle, og dødeligheten er relativ høy. Det betyr at behovet for alternative behandlingsstrategier er stort. Gjennom økt biologisk forståelse kan man utvikle mer målrettede behandlinger som ...

    • The role of interleukin-1 receptor antagonist in normal and malignant hematopoiesis 

      Villatoro, Alicia (Doctoral thesis; Doktorgradsavhandling, 2022-09-08)
      Interleukin-1β (IL-1β) is a pleiotropic inflammatory cytokine that exerts multiple roles in both physiological and pathological conditions. Enhanced IL-1β signaling drives hematopoietic stem cell (HSC) differentiation into the myeloid lineage and is actively involved in the development and progression of hematological malignancies, including deadly acute myeloid leukemia (AML). Inhibition of IL-1β ...

    • Role of Laeverin in the pathophysiology of preeclampsia 

      Nystad, Mona (Doctoral thesis; Doktorgradsavhandling, 2018-05-11)
      Preeclampsia is a pregnancy-specific disease, affecting 5-10% of human pregnancies worldwide. It is defined as new-onset hypertension after 20 weeks of gestation with either proteinuria and/or organ failure. Laeverin is a membrane-bound aminopeptidase exclusively expressed in the placenta. Our previous studies revealed a significant upregulation of laeverin mRNA in preeclamptic placentas, building ...

    • Role of Mannose-Binding Lectin and Complement Activation in Venous Thromboembolism 

      Liang, Robin Amanda (Doctoral thesis; Doktorgradsavhandling, 2019-12-17)
      The complement and coagulation systems are two interrelated plasma protein cascades. Evidence from observational and animal studies has proposed a role for the complement system in the development of venous thromboembolism (VTE), but the exact mechanisms remain obscure. The aim of this thesis was to investigate whether activation of the complement system impacts the risk of VTE and to investigate ...

    • Role of monocyte procoagulant functions in the pathophysiology of arterial and venous thrombosis 

      Goolyam Basavaraj, Manjunath (Doctoral thesis; Doktorgradsavhandling, 2011-12-16)
      Monocytter, en klasse hvite blodlegemer i blodet, spiller en sentral rolle i kroppens immunforsvar og for blodets evne til å levre seg og danne en blodpropp. De kan ved stimulering, som ved sykelige tilstander, uttrykke vevsfaktor (TF) på celleoverflaten. TF er ansvarlig for å sette i gang blodproppmekanismen. En blodpropp kan dannes i kroppens samleårer (vener – kalles da dyp venøs trombose eller ...

    • The role of ovarian reserve markers in fertility and fertility treatment 

      Bhide, Priya (Doctoral thesis; Doktorgradsavhandling, 2021-05-14)
      Ovarian reserve is a key component influencing reproductive function and fertility. Serum anti-Mullerian hormone (AMH) and antral follicle count (AFC) are established quantitative markers of ovarian reserve. The overall aim of this thesis comprising four work packages was to study the role of AMH and AFC on different aspects of fertility and fertility treatment. Their specific objectives were: 1) To ...

    • The Role of Plasma Extracellular Vesicles and Procoagulant Phospholipid Activity in Venous Thromboembolism 

      Ramberg, Cathrine (Doctoral thesis; Doktorgradsavhandling, 2021-11-05)
      Venous thromboembolism (VTE) is the formation of a blood clot in, most commonly, the deep veins of the lower extremities and the pulmonary circulation. VTE is a prevalent disease associated with severe short- and long-term complications. Negatively charged procoagulant phospholipids (PPL), and phosphatidylserine (PS) in particular, are vital to efficient coagulation activation, and found expressed ...

    • The role of Staphylococcus aureus in allergic disease and cross-reactivity in fish allergy 

      Sørensen, Martin (Doctoral thesis; Doktorgradsavhandling, 2017-09-29)
      Aims: The aims was to describe prevalence`s of allergic disease in adolescents and study associations between allergic diseases and Staphylococcus aureus. Secondly, to study cross-reactivity in fish allergic children and the utility of existing and novel tests for fish allergy. Material and Methods: Prevalence of allergic diseases and associations to Staphylococcus aureus was studied in a cross-sectional ...

    • The role of steroid hormone receptors in prostate cancer. A study of estrogen- and progesterone receptors in adenocarcinoma of the prostate 

      Grindstad, Thea Karoline Walstad (Doctoral thesis; Doktorgradsavhandling, 2018-06-15)
      Steroid hormones and their receptors are vital for numerous physiological processes in the human body, but also related to the development of several malignancies. One such receptor strongly associated with prostate cancer, is the androgen receptor. Other steroid hormone receptors are also implicated in prostate cancer, their role, however, remains to be defined. Using immunohistochemistry and tissue ...