English
norskBlar i tittel Doktorgradsavhandlinger (Helsefak)
Viser treff 335-354 av 697
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LDL apheresis beyond lipid reduction : a study of three different apheresis columns in heterozygous familial hypercholesterolemia and ex vivo
(Doctoral thesis; Doktorgradsavhandling, 2012-06-01)When low density lipoprotein (LDL) cholesterol cannot be adequately controlled by medications, it is possible to reduce LDL-cholesterol by means of LDL apheresis. This extracorporeal treatment is most often used in familial hypercholesterolemia (FH). The procedure is known to reduce LDL-cholesterol significantly. Few studies however, have prospectively and systematically examined how different LDL ... -
Learning from what might have been – judgments and evaluations of counterfactual outcomes
(Doctoral thesis; Doktorgradsavhandling, 2018-03-23)The aim of the present thesis is to contribute to the understanding of how people construct hypothetical alternatives to past events, and further explore the role of such counterfactual thinking in learning from accidents and near-accidents. In Paper 1 we introduced the notion that counterfactual thinking is a form of mental simulation that relies on abstract, gist based representations of the ... -
Life after war-related extremity amputations. A retrospective, descriptive clinical follow-up study from Gaza, occupied Palestine
(Doctoral thesis; Doktorgradsavhandling, 2019-08-23)Little is known about medical consequences of losing arm(s) or leg(s) in military attacks. Many Palestinians in Gaza have suffered loss of one or more limbs during recurrent Israeli military incursions. Such serious physical trauma pose grave health problems not only for the amputee, but also for their families and for the society at large. The problem is increasing. Hanne Heszlein-Lossius, MD, ... -
Lifestyle factors and colorectal cancer: The Norwegian Women and Cancer Study
(Doctoral thesis; Doktorgradsavhandling, 2020-03-27)Colorectal cancer (CRC) is a major global disease. The incidence rate among Norwegian women is currently the highest in the world. Lifestyle factors have a substantial influence on CRC susceptibility. However, it is not clear whether these factors are responsible for the high incidence in Norwegian women, or whether they play a role in CRC survival. This doctoral project investigated lifestyle factors ... -
Lifestyle factors and risk of venous thromboembolism
(Doctoral thesis; Doktorgradsavhandling, 2013-06-13)SUMMARY There is little knowledge about the association between lifestyle factors and risk of venous thromboembolism (VTE). The aim of this thesis was to investigate the relation between coffee consumption, emotional states, cigarette smoking and socioeconomic status and future risk of incident VTE in a prospective, population-based cohort study. Our study population consisted of more than 27 ... -
Ligand binding and dynamics of the GABAB receptor Venus flytrap domain
(Doctoral thesis; Doktorgradsavhandling, 2019-11-15)<p>The gamma-amino-butyric-acid (GABA) is the main inhibitory neurotransmitter in the central nervous system (CNS) and exerts its physiological role by binding to the ionotropic GABA<sub>A</sub> and GABA<sub>C</sub> receptors and the metabotropic GABA<sub>B</sub> receptor (GABA<sub>B</sub>-R). The GABA<sub>B</sub>-R is an obligate heterodimer that belongs to class C of guanine-binding proteins ... -
“Light my fire” - Perspectives on Motivation, Helpfulness and Implementation of Guided Internet-based Cognitive Behavioral therapy.
(Doctoral thesis; Doktorgradsavhandling, 2015-03-13)Depression is common and imposes tremendous burdens for patients, their family and society. Implementation of internet-based cognitive behavioural therapy (ICBT) within general practice is recommended. Better results have been shown for treatment with ICBT when support is given, and therefore there is interest in exploring guided ICBT as an affordable alternative for treatment in the early stage ... -
Lightweight methods, heavyweight organisations. Transforming a small tailored product to a large integrated healthcare information system.
(Doctoral thesis; Doktorgradsavhandling, 2012-09-28)The building of large scale information systems in healthcare is a current issue in Norway. Such systems are often built as large systems from the start. This thesis studies another approach: small tailored solutions that grow to become large integrated systems. This thesis adheres to an interpretive research approach, and the empirical material comes from the development of an electronic system for ... -
Liver regeneration : the impact of altered portal hemodynamics on gene expression and growth of the porcine liver
(Doctoral thesis; Doktorgradsavhandling, 2010-12-10)Previous research on liver regeneration has focused on the volume and composition of the blood perfusing the liver remnant and their relative importance in initiating the cascade of liver regeneration after partial hepatectomy. Newer studies around year 2000 indicated nitric oxide was of paramount importance due to the increased shear stress in liver sinusoids. On the basis of experimental liver ... -
Living with ethical dilemmas : the ethical reasoning of surgeons and nurses in surgical units
(Doctoral thesis; Doktorgradsavhandling, 2010-04-13)The aim of this thesis is to illuminate surgeons’ and nurses’ experiences of living with ethical dilemmas in their work. The thesis comprises the kinds of ethical dilemmas experienced from the practitioners’ own point of view, and explores their way of reasoning, deliberating and acting in ethically difficult situations, including the meaning they assign to their experiences. The data collection ... -
Living with voices and sounds other cannot hear
(Doctoral thesis; Doktorgradsavhandling, 2016-03-31)Hearing voices and sounds unshared by others, often termed auditory (verbal) hallucinations, is commonly known as a symptom of serious mental illness. The fact that it is not uncommon in the general population has led to research focused on hearing voices and sounds as experiences in themselves. The aim of this research project was to understand how people experience hearing and dealing with voices ... -
Local public health physicians in Norway from 1994 to 2002 : workload, work content, and interaction : a story of everyday life in primary health care
(Doctoral thesis; Doktorgradsavhandling, 2008-03-07)Avhandlingens tema er utviklingen innenfor lokal samfunnsmedisinsk legetjeneste fra 1994 til 2002. Desentraliserings- og liberaliseringsreformer i primærhelsetjenesten, endringer i helseforhold og etterspørsel etter helsetjenester endret arbeidsarenaen for samfunnsmedisinerne, og gav økonomiske, organisatoriske og faglige utfordringer. Avhandlingen er basert på tre tverrsnittsundersøkelser, gjennom ... -
Long-term exercise maintenance via telerehabilitation for people with COPD. Feasibility, effectiveness, benefits and challenges
(Doctoral thesis; Doktorgradsavhandling, 2019-06-06)Background and aims: The availability of pulmonary rehabilitation (PR) and exercise maintenance programs for people with chronic obstructive pulmonary disease (COPD) is low, despite being beneficial and recommended. Telerehabilitation can support the delivery of such programs to patients’ homes. However, there is little knowledge of its benefits for people with COPD. This thesis aimed to investigate ... -
Long-term experiences of living with stroke in a family context
(Doctoral thesis; Doktorgradsavhandling, 2012-10-26)Hvert år rammes cirka 15 000 nordmenn av hjerneslag og mange får sammensatte og vedvarende funksjonshemninger. Sykdommen har vidtrekkende konsekvenser på alle livets områder og rammer hele familien. Ektefellens livskvalitet blir påvirket og barn kan få atferdsproblemer relatert til foreldrenes reaksjoner. Hovedhensikten med Doktorgradsprosjektet var å belyse livserfaringene til mennesker som lever ... -
Longitudinal changes in forearm bone mineral density in women and men from 25 to 84 years. The Tromsø Study
(Doctoral thesis; Doktorgradsavhandling, 2006) -
Lumbosacral radiculopathy managed in multidisciplinary back clinics. Diagnostic accuracy, prognostic factors and efficacy of epidural injection therapy.
(Doctoral thesis; Doktorgradsavhandling, 2015-10-27)The accuracy of individual clinical index tests used to predict imaging findings of nerve root impingement in patients with chronic lumbar radiculopathy is low when applied in specialized care, but clinicians’ overall evaluation improves diagnostic accuracy slightly. The diagnostic accuracy of individual index tests was low with no tests reaching positive LR >4.0 or negative LR <0.4. The overall ... -
Lupus nephritis : the role of renal DNase I in the progression of the disease
(Doctoral thesis; Doktorgradsavhandling, 2011-05-31)SLE er en sykdom med ukjent etiologi. En hovedmarkør for sykdommen SLE er produskjon av antistoffer mot kroppseget DNA (arvestoff). Binding av slike antistoffer til DNA fører til dannelse av immunkomplekser som i sin tur avleires i organer og bidrar til kliniske symptomer og sykdomsutvikling. I nyrene forårsakes det lekkasje av eggehvite (proteinuri) og er et tegn på alvorlig nyresvikt. Vi ... -
Magnetic resonance imaging of pancreatic islets transplantation
(Doctoral thesis; Doktorgradsavhandling, 2012-08-30)Transplanted insulin-producing cells can be safely monitored by magnetic resonance imaging Transplantation of insulin-producing cells can treat patients with diabetes. Unfortunately, the long-term effects of this treatment are poor due to non-survival of the majority of the transplanted cells. In our study, we found that magnetic resonance imaging (MRI) can be safely used to trace survival of the ... -
Managing childhood obesity, The Finnmark Activity School
(Doctoral thesis; Doktorgradsavhandling, 2014-12-11)Childhood obesity has reached epidemic proportions globally and represents a major threat to children’s health. Data on effectiveness of treatment programs for childhood obesity beyond one year is limited and there is little high-quality evidence to recommend one treatment over another. The objective of the clinical trial The Finnmark Activity School was to compare a new multidisciplinary approach ... -
Managing exacerbations of chronic obstructive pulmonary disease - An investigation of treatment decisions from a primary care perspective
(Doctoral thesis; Doktorgradsavhandling, 2017-03-24)Exacerbations of chronic obstructive pulmonary disease (COPD) compose a considerable burden for both patients and health care systems. Optimal management in primary care, including self-treatment of COPD exacerbations with antibiotics and oral corticosteroids, is considered to be one key for providing good care for patients at reasonable costs. This thesis aimed to explore treatment of COPD exacerbations ...
