Neuroblastoma is the most common extra-cranial tumour disease in children, and accounts for 15% of all childhood cancer deaths. MYCN is a transcription factor and a proto-oncogene that most often initiates transcription of target genes involved in increased proliferation and inhibition of differentiation. MYCN amplified neuroblastoma represents the most aggressive form of this disease. Silencing of ...

Hodepine er en av de vanligste plager hos mennesket, og er også den hyppigste årsaken til at pasienter oppsøker helsevesenet. På grunn av det store geografiske dekningsområdet for to nevrologiske avdelinger i Nord-Norge, mangler mange hodepinepasienter tilgjengelighet til god spesialisthelsetjeneste. Mangel på hodepinespesialister og tungvinn tilgang til omsorg kan gi grobunn for feildiagnostisering, ...

The present thesis` main objective was to examine time-trends related to CBT as an anti-depressive treatment. A meta-analytic approach was the tool for such investigations, in which the formats of individual, group (GCBT), and mindfulness-based cognitive behavioral therapy (MCBT) were explored from a temporal point of view, and the results subsequently summarized in four articles. The meta-analyses ...

The temporomandibular joint (TMJ) is commonly involved in juvenile idiopathic arthritis (JIA), and may lead to impaired mouth opening, pain and facial growth disturbances. Asymptomatic TMJ arthritis may be diagnosed late in the disease course, thus management is challenging. The overall objectives of this thesis were to provide new knowledge on quality of life (QoL), the oral microbiome and interventions ...

Persistent bodily symptoms without medical clarity creates many layers of uncertainty both for health professionals and for patients. In primary care, research has shown that clinical encounters of medically unexplained symptoms (MUS) are highly contentious, sometimes causing adverse effects. However, little is known about communicative challenges for adolescents in specialist health care settings; ...

‘Good health for all’ and ‘employment for all’ are two widely agreed-upon goals in Norwegian politics. Nevertheless, considerable inequalities in health exist, and the economic sustainability of public pensions is pressured by a substantial increase in life expectancy. Improving our understanding of inequalities in health and the relationship between health detriments and labour market participation ...

This thesis aims to: i) explore the importance of preference-weighting in health state utility (HSU) instruments and ii) examine the contribution of policy-relevant factors to subjective well-being (SWB). The analyses herein are based on an international sample of individuals aged 18 and above, and this thesis comprises three papers. Paper 1 examined the relative importance of preference-weighting ...

In order for the HIV virus to take over and destroy human immune cells, which results in AIDS, the virus first has to enter the cells. This takes place by interactions between viral proteins and specific receptors on the surface of our cells. One of these receptors is CXCR4, and it has been shown that chemical compounds that bind to and block the CXCR4 receptor, so-called CXCR4 antagonists, are able ...

Dát čielggadeapmi geahččala čájehit ovttasdoaimma báikkálaš veahkehanárbevieruid ja almmolaš psykalaš dearvvašvuođabálvalusaid gaskka Finnmárkkus ja Davvi-Romssas, ja jearrá galggašii go dán guovtti vuogi gaskka leat eanet ovttasbargu. Danne geahčadit dás dárkileappot mat báikkálaš veahkehanárbevierut leat dáid sámi ja máŋggakultuvrralaš guovlluin, man ollu pasieanttat geavahit dáid, ja háliidit ...

Akuttmedisinske pasienter har ofte krevende og komplekse medisinske behov som lokale, tverrfaglige team må bidra til å møte. Akuttmedisinforskriften pålegger trening i samhandling for tjenestene utenfor sykehus. Vi ønsket derfor å utforske og forbedre lokal team trening. I Alta har lokalt helsepersonell systematisk arrangert slike treninger hver måned siden 2007, forankret i egen kompetanse og egen ...