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norskBlar i tittel Doktorgradsavhandlinger (Helsefak)
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Venous Air Embolism and Complement-driven Thromboinflammation. In vitro human whole blood studies and in vivo porcine studies on the effect of air emboli on the complement system, cytokine network, and the hemostasis
(Doctoral thesis; Doktorgradsavhandling, 2022-09-27)<p><i>Background:</i> Air embolism may complicate many medical procedures and cause vascular occlusion, organ infarctions, or death. In vitro, air triggers the alternative complement pathway and activates platelets. Previous studies of air emboli were conducted in serum, plasma, or heparin anticoagulated whole blood, with ambient air present in tubes, precluding detailed examination of thromboinflammation. ... -
Venous thromboembolism and cancer
(Doctoral thesis; Doktorgradsavhandling, 2017-06-27)Venous thromboembolism (VTE) is a collective term for deep vein thrombosis and pulmonary embolism. VTE is a common cause of mortality and morbidity in patients with cancer, and may also be the first sign of an underlying malignancy. The first aim of this thesis was to investigate the risk of incident and recurrent VTE in active cancer compared to a cancer-free reference population and to explore the ... -
Venous thromboembolism: incidence, recurrence and mortality
(Doctoral thesis; Doktorgradsavhandling, 2018-08-29)Deep vein thrombosis (DVT) and pulmonary embolism (PE), collectively referred to as venous thromboembolism (VTE), is associated with substantial morbidity and mortality. To plan and evaluate prevention and treatment strategies for VTE, understanding into the epidemiology and current magnitude of VTE is needed. The aims of this thesis were (i) to assess time-trends in the incidence of VTE in the ... -
Vertebral fractures: Prevalence, risk factors, and health-related quality of life. A cross-sectional study The Tromsø study 2007/2008
(Doctoral thesis; Doktorgradsavhandling, 2013-11-08)Summary Background: Osteoporotic fractures constitute a major health burden in western societies. Forearm, vertebral-, and hip fractures are the most common types. Norway has the highest reported prevalence of forearm- and hip fractures. Little data has been available concerning vertebral fractures, although these, together with the hip fractures, are associated with increased morbidity ... -
Virtual dissection of cardiac motion : what do we measure by strain and strain rate imaging?
(Doctoral thesis; Doktorgradsavhandling, 2010-09-17)Since the introduction of strain and strain rate measurements in echocardiography of the heart, many studies have demonstrated that these parameters quantify effectively and precisely regional myocardial deformation. The method allows to measure and quantify regional myocardial function. Different cardiac diseases might be detected at an earlier stage. However, there are many factors influencing ... -
Visual methods in health dialogue and public health work. An action research approach to improve school nurses’ work with adolescents
(Doctoral thesis; Doktorgradsavhandling, 2020-01-29)School nursing involves relationships and understandings based on young people’s needs. Visual technologies have become a central part of young people’s life and context: they use their phones to communicate and shape their relationships and they turn to social media when inquiring about health issues. Visual methods in health communication thus draw on existing practices, and are well documented ... -
Vitamin D and its implication on inflammation and genomics. The data from the Tromsø Study and the U.S. National Health and Nutrition Examination Survey
(Doctoral thesis; Doktorgradsavhandling, 2017-11-24)Det har vært en økende interesse for vitamin D sin rolle i patogenese av inflammasjonsrelaterte sykdommer, metabolske forstyrrelser, hjertekarsykdommer og cancer. Mange observasjonsstudier har antydet en sammenheng mellom redusert vitamin D nivå og økt risiko for disse sykdommene. Vårt mål var å undersøke denne sammenhengen i to store observasjonsstudier: den norske Tromsøundersøkelsen og den ... -
Vitamin D, Depression and Headache - Results from the Tromsø Study and an intervention study with vitamin D
(Doctoral thesis; Doktorgradsavhandling, 2013-04-19)Vitamin D is well known for the effect in bone metabolism and calcium regulation. In the past decade increasing evidence that vitamin D might be important in other areas has emerged. Especially glucose metabolism, cardiovascular disease and infectious diseases have been investigated. In addition, several population studies have shown that an association between vitamin D and depression might be of ... -
Vitamin D: Relations with Sleep and Bone Mineral Density. Insights from the Tromsø Study and randomized controlled trials
(Doctoral thesis; Doktorgradsavhandling, 2022-06-10)In this thesis, the relationship between vitamin D and health-related outcomes has been investigated. More than 21,000 individuals participated in the Tromsø Study 2015-16. The participants donated blood samples and filled in questionnaires regarding their health status, including questions about their sleep health. Using these data, the association between vitamin D and sleep duration, daytime ... -
Waiting for nursing home placement: a study of the life situation of frail elderly and their carers
(Doctoral thesis; Doktorgradsavhandling, 2009-01-30)Den forventede levealderen har økt nesten over hele verden. Dette har ført til at antall eldre stiger raskt, og veksten er ventet å fortsette. I Norge vokser gruppen eldre over 80 år raskest. Det er gjennomført mye internasjonal forskning om eldre og det å være deres pårørende. Fokus i denne studien var eldre som ventet på sykehjemsplass i en nordnorsk kommune, og deres pårørende. Det ble ikke ... -
We Ran a Hospital. The Norwegian Nurses efforts During the Korean War and the Impact of their Experiences on Norwegian Nursing and Theatre Nursing
(Doctoral thesis; Doktorgradsavhandling, 2021-04-23)<p>During the Korean War (1951-53), Norway operated and staffed a surgical field hospital at the front along the 38th parallel. The Norwegian Mobile Army Surgical Hospital – NORMASH – was a part of the United Nations peace-enforcing force to stop aggression from North-Korea towards South-Korea. <p>NORMASH was staffed only with civilian volunteers. Without any training as a military group or in war ... -
Weight change and cancer
(Doctoral thesis; Doktorgradsavhandling, 2020-05-25)<p><i>Background: </i>The obesity prevalence has reached pandemic dimensions. The cancer incidence has also increased worldwide, and several cancers are related to body fatness. However, there are uncertainties weather the velocity and magnitude of weight gain, independent of body fatness, increase cancer risk. Moreover, there are few studies on short-term weight gain and site-specific cancers. Thus, ... -
What are the molecular consequences of germline mutations in breast and ovarian cancer susceptibility genes in a Norwegian breast and ovarian cancer population?
(Doctoral thesis; Doktorgradsavhandling, 2018-06-01)It is estimated that 5-10% of breast cancers (BC) and 25% of ovarian cancers (OC) are caused by inherited sequence variants in genes. In the mid 90’s, the two genes BRCA1 and BRCA2 were discovered to be directly associated with increased risk of BC and OC. Molecular screening of these two genes has revealed several disease causing variants as well as variants of unknown clinical significance (VUS). ... -
When Bodies Speak and Words Act - poetry, psychosomatic illness and the lost art of medicine
(Doctoral thesis; Doktorgradsavhandling, 2020-04-16)This is a discussion of what poetry has to do with medicine. It is about the psychological necessity and communicative purpose of art, with poetry as an example. It is about what poetry demands of the poet - humility, undogmatic diligence, resilience in the face of complexity, and the ability to think and feel at the same time. It is about a vital service poetry performs for poet and public which ... -
When coercion moves into your home. A study of outpatient commitment in Northern Norway
(Doctoral thesis; Doktorgradsavhandling, 2016-12-08)”Når tvangen flyttes hjem i stua” Tvang overfor pasienter som bor hjemme erfares annerledes enn hvordan vi vanligvis tenker om tvang i psykisk helsevern, viser en ny studie fra UIT. Tvunget psykisk helsevern uten døgnopphold (TUD) betyr at pasienten bor utenfor sykehus, men fortsatt er underlagt tvang. Dette innebærer en avgrenset mulighet for å bruke tvang : 1. Pasienten kan hentes, eventuelt ... -
When is remission remission? Elucidating the remission state in Ulcerative Colitis: a multimodal exploration
(Doctoral thesis; Doktorgradsavhandling, 2021-10-22)Ulcerative Colitis (UC) is a chronic, inflammatory disease of the colon that has a relapsing-remitting characteristic. The disease management consists of prolonging periods of remission and reducing relapse frequency. There is currently no universally accepted definition of remission in UC. There are different methods of establishing if a patient is in remission, but the lack of definition and ... -
Why do students leave? Student-related factors and attrition intentions
(Doctoral thesis; Doktorgradsavhandling, 2023-06-20)Established as a collection of scholars protecting their shared interests, higher education has become a driving force of economic development accountable to the government and society. However, changes in higher education have been accompanied by multiple challenges, including funding and quality assessment. This dissertation addresses one of these challenges facing academic institutions, academic ... -
Why is it safe – enough? Decision-making in avalanche terrain
(Doctoral thesis; Doktorgradsavhandling, 2021-10-25)The snowy mountains of the world attract an increasing number of backcountry recreationalists, but nice skiing comes with a risk. Every year about 140 people in Europe and North America lose their life in avalanche accidents. 9 out of 10 accidents are triggered by the victim or someone in their party. Therefore, improving decision-making is important. Avalanche terrain decision-making is complex ... -
‘Will I get cancer again?’ An ethnography of worries, healing landscapes and sensation-to-symptom processes among people living in the aftermath of cancer in rural Norway
(Doctoral thesis; Doktorgradsavhandling, 2019-04-29)<p>Today, 71% of those who are diagnosed with cancer live five years or longer after treatment. Although the level of mortality varies considerably between different cancer diagnoses, the total number of people who recover after cancer is increasing. There is a need to gain knowledge on how people who live in the aftermath of cancer treatment experience health and illness, bodily sensations, everyday ... -
Wound healing in diabetes. An intervention study in db/db mice
(Doctoral thesis; Doktorgradsavhandling, 2017-06-09)The prevalence of diabetes is increasing globally. Certain microvascular and macrovascular complications such as cardiovascular disease, retinopathy, nephropathy, neuropathy, and impaired wound healing are associated with the disease. Prolonged exposure to hyperglycaemia plays an important role in their development. Glucose reacts with macromolecules including proteins, lipoproteins, and nucleic ...
