• Circulating regulators of the wingless pathway in precapillary pulmonary hypertension 

      Ueland, Thor; Abraityte, Aurelija; Norum, Hilde; Varathalingam, Sharanga; Gullestad, Lars; Aukrust, Pål; Andreassen, Arne K. (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-04-08)
      Background and objective - Dysregulated Wnt signalling has been implicated in pulmonary hypertension (PH). We hypothesized that plasma levels of secreted Wnt proteins would be increased in patients with precapillary PH, correlate with indices of vascular resistance and cardiac function and give information on long-term prognosis.<p> <p>Methods - We measured the Wnt ligand Wnt5a and secreted Wnt ...
    • T cell and monocyte/macrophage activation markers associate with adverse outcome, but give limited prognostic value in anemic patients with heart failure: results from RED-HF 

      Abraityte, Aurelija; Aukrust, Pål; Kou, Lei; Anand, Inder S.; Young, James; Mcmurray, John J.V.; van Veldhuisen, Dirk J.; Gullestad, Lars; Ueland, Thor (Journal article; Tidsskriftartikkel, 2018-07-26)
      <i>Background</i>: Activated leukocytes may contribute to the development and progression of heart failure (HF). We investigated the predictive value of circulating levels of stable and readily detectable markers reflecting both monocyte/macrophage and T-cell activity, on clinical outcomes in HF patients with reduced ejection fraction (HFrEF).<p> <p><i>Methods</i>: The association between ...