Blar i forfatter Artikler, rapporter og annet (UB) "Andreassen, Arne K."

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    • The carnitine-butyrobetaine-TMAO pathway after cardiac transplant: Impact on cardiac allograft vasculopathy and acute rejection 

      Trøseid, Marius; Mayerhofer, Christiane Caroline; Broch, Kaspar; Arora, Satish; Svardal, Asbjørn M.; Hov, Johannes Espolin Roksund; Andreassen, Arne K.; Gude, Einar; Karason, Kristjan; Dellgren, Gøran; Berge, Rolf Kristian; Gullestad, Lars; Aukrust, Pål; Ueland, Thor (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-06-19)
      <p><i>BACKGROUND - </i>Alterations in the partly microbiota-dependent carnitine–γ-butyrobetaine (γBB)–trimethylamine N-oxide (TMAO) pathway have been linked to the progression of heart failure and atherosclerotic disease. We evaluated if circulating γBB, TMAO, and their common precursors carnitine and trimethyllysine (TML) were dysregulated after heart transplantation and associated with development ...

    • Circulating regulators of the wingless pathway in precapillary pulmonary hypertension 

      Ueland, Thor; Abraityte, Aurelija; Norum, Hilde; Varathalingam, Sharanga; Gullestad, Lars; Aukrust, Pål; Andreassen, Arne K. (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-04-08)
      Background and objective - Dysregulated Wnt signalling has been implicated in pulmonary hypertension (PH). We hypothesized that plasma levels of secreted Wnt proteins would be increased in patients with precapillary PH, correlate with indices of vascular resistance and cardiac function and give information on long-term prognosis.<p> <p>Methods - We measured the Wnt ligand Wnt5a and secreted Wnt ...

    • Distinct patterns of soluble leukocyte activation markers are associated with etiology and outcomes in precapillary pulmonary hypertension 

      Lekva, Tove; Gullestad, Lars; Broch, Kaspar; Aukrust, Pål; Andreassen, Arne K.; Ueland, Thor (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-10-29)
      Activation of inflammatory processes has been identified as a major driver of pulmonary vascular remodeling that contributes to the development of precapillary pulmonary hypertension (PH). We hypothesized that circulating markers of leukocyte activation, reflecting monocytes/macrophages (sCD163, sCD14), T-cells (sCD25) and neutrophils (myeloperoxidase [MPO], neutrophil gelatinase-associated lipocalin ...