Blar i forfatter Artikler, rapporter og annet (UB) "Vaaje-Kolstad, Gustav"

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    • The lytic polysaccharide monooxygenase CbpD promotes Pseudomonas aeruginosa virulence in systemic infection 

      Askarian, Fatemeh; Uchiyama, Satoshi; Masson, Helen; Sørensen, Henrik Vinther; Golten, Ole; Bunæs, Anne Cathrine; Mekasha, Sophanit; Røhr, Åsmund Kjendseth; Kommedal, Eirik Garpestad; Ludviksen, Judith Anita; Arntzen, Magnus Øverlie; Schmidt, Benjamin; Zurich, Raymond H.; Van Sorge, Nina M.; Eijsink, Vincent; Krengel, Ute; Mollnes, Tom Eirik; Lewis, Nathan E.; Nizet, Victor; Vaaje-Kolstad, Gustav (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-02-23)
      The recently discovered lytic polysaccharide monooxygenases (LPMOs), which cleave polysaccharides by oxidation, have been associated with bacterial virulence, but supporting functional data is scarce. Here we show that CbpD, the LPMO of <i>Pseudomonas aeruginosa</i>, is a chitin-oxidizing virulence factor that promotes survival of the bacterium in human blood. The catalytic activity of CbpD was ...