We report a mild superbase-catalyzed and nitrogen-selective carboxylation of N-heteroaryls, with subsequent alkylation enabling the synthesis of drug-like O-alkyl carbamates in good yields (av. 86%). Our findings suggest a partial revision of the current mechanistic understanding as superbases upon mixing with indoles and azoles generally form uncharged hydrogen-bonded complexes and not ionic salts ...

Imaging non-adherent cells by super-resolution far-field fluorescence microscopy is currently not possible because of their rapid movement while in suspension. Holographic optical tweezers (HOTs) enable the ability to freely control the number and position of optical traps, thus facilitating the unrestricted manipulation of cells in a volume around the focal plane. Here we show that immobilizing ...

Bottom trawling is used to capture fish species that live in the seabed. The damage on the seabed trawling causes has been discussed for many years. This thesis aims to investigate whether bottom trawling for sand eels can be a cause for some of the detected oil seepages in the North Sea. We investigated this using manual delineation of oil seepages in Synthetic Aperture Radar (SAR) satellite ...

The design and synthesis of copper complexes that can reduce nitrite to NO has attracted considerable interest. They have been guided by the structural information on the catalytic Cu centre of the widespread enzymes Cu nitrite reductases but the chemically novel side-on binding of NO observed in all crystallographic studies of these enzymes has been questioned in terms of its functional relevance. ...

Geophysical evidence of a prominent BSR at Vestnesa Ridge and north to the northern flank of the Storegga slide escarpment infer that gas hydrates are ubiquitous within these regions. A wide range of fluid flow structures have previously been discovered from these regions, as well as gas seepage activity from pockmarks on the eastern segment of Vestnesa Ridge. This paper focuses on high-resolution ...

Foredrag av Arthur E. Wilder-Smith og Udo Middelmann holdt ved NTH i 1979

Luftambulansetjenesten HF har i dag kontrakt med Avincis Aviation Services, som opererer luftambulanseflyene i Norge. Denne delen av tjenesten hadde 109.095 oppdrag i tiårsperioden 2013-2022, hvorav 30.0% var haste- eller akuttoppdrag. Luftambulansetjenesten har blitt beskrevet av flere som en samfunnskritisk ressurs, da befolkningen i Norge har rett på lik medisinsk behandling uavhengig av ...

Understanding changes in Antarctic ice shelf basal melting is a major challenge for predicting future sea level. Currently, warm Circumpolar Deep Water surrounding Antarctica has limited access to the Weddell Sea continental shelf; consequently, melt rates at Filchner‐Ronne Ice Shelf are low. However, large‐scale model projections suggest that changes to the Antarctic Slope Front and the coastal ...

Recent developments in augmented reality technology have paved way for newapplications in a wide range of areas. These include the commercial markets,medicine applications, military applications and education. The technology pro-vides immersive images to enhance our perception of the world. Augmentedreality addresses challenges related to problem-solving by seamlessly integrat-ing digital images ...

<p>Organic-walled dinoflagellate cysts and acritarchs are a vital tool for reconstructing past environmental change, in particular in the Neogene of the high northern latitudes where marine deposits are virtually barren of traditionally used calcareous microfossils. Yet only little is known about the paleoenvironmental value of fossil assemblages that do not have modern analogues, so that reconstructions ...