Blar i tittel Artikler, rapporter og annet (medisinsk biologi)

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    • B Cell Tolerance to Deiminated Histones in BALB/c, C57BL/6, and Autoimmune-Prone Mouse Strains 

      Dwivedi, Nishant; Hedberg, Annica; Zheng, Ying Yi; Neeli, Indira; Satoh, Minoru; Morel, Laurence; Rekvig, Ole Petter; Radic, Marko (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-03-30)
      Deimination, a posttranslational modification of arginine to citrulline carried out by peptidylarginine deiminases, may compromise tolerance of self-antigens. Patients with connective tissue autoimmunity, particularly rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), or Felty’s syndrome, present with autoantibodies to deiminated histones (dH), which thus form a category of antibodies ...

    • B4GALT family mediates the multidrug resistance of human leukemia cells by regulating the hedgehog pathway and the expression of p-glycoprotein and multidrug resistance-associated protein 1 

      Zhou, Humin; Ma, Hongye; Wei, Wei; Ji, Donghua; Song, Xiaobo; Sun, Jinglu; Zhang, Jianing; Jia, Li (Journal article; Tidsskriftartikkel; Peer reviewed, 2013)
      b-1, 4-Galactosyltransferase gene (B4GALT) family consists of seven members, which encode corresponding enzymes known as type II membrane-bound glycoproteins. These enzymes catalyze the biosynthesis of different glycoconjugates and saccharide structures, and have been recognized to be involved in various diseases. In this study, we sought to determine the expressional profiles of B4GALT family ...

    • Bacterial genomic epidemiology with mixed samples 

      Mäklin, Tommi; Kallonen, Teemu; Alanko, Jarno; Samuelsen, Ørjan; Hegstad, Kristin; Mäkinen, Veli; Corander, Jukka; Heinz, Eva; Honkela, Antti (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-11-15)
      Genomic epidemiology is a tool for tracing transmission of pathogens based on whole-genome sequencing. We introduce the mGEMS pipeline for genomic epidemiology with plate sweeps representing mixed samples of a target pathogen, opening the possibility to sequence all colonies on selective plates with a single DNA extraction and sequencing step. The pipeline includes the novel mGEMS read binner for ...

    • Bacterial interference with canonical NF kappa B signalling 

      Johannessen, Mona; Askarian, Fatemeh; Sangvik, Maria; Sollid, Johanna U. Ericson (Journal article; Tidsskriftartikkel; Peer reviewed, 2013-10)

    • Bacterial membrane-derived vesicles attenuate vancomycin activity against methicillin-resistant staphylococcus aureus 

      Kumaraswamy, Monika; Wiull, Kamilla; Joshi, Bishnu; Sakoulas, George; Kousha, Armin; Vaaje-Kolstad, Gustav; Johannessen, Mona; Hegstad, Kristin; Nizet, Victor; Askarian, Fatemeh (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-09-29)
      Methicillin-resistant Staphylococcus aureus (MRSA) has evolved numerous antimicrobial resistance mechanisms and is identified as a serious public health threat by the World Health Organization and U.S. Centers for Disease Control and Prevention. The glycopeptide vancomycin (VAN) remains a cornerstone of therapy for severe MRSA infections despite increasing reports of therapeutic failure in hospitalized ...

    • Basal‐like breast cancer engages tumor‐supportive macrophages via secreted factors induced by extracellular S100A4 

      Prasmickaite, Lina; Tenstad, Ellen; Pettersen, Solveig; Jabeen, Shakila; Egeland, Eivind Valen; Nord, Silje; Pandya, Abhilash D.; Haugen, Mads Haugland; Kristensen, Vessela N.; Børresen-Dale, Anne-Lise; Engebråten, Olav; Mælandsmo, Gunhild Mari (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-05-09)
      The tumor microenvironment (TME) may influence both cancer progression and therapeutic response. In breast cancer, particularly in the aggressive triple‐negative/basal‐like subgroup, patient outcome is strongly associated with the tumor's inflammatory profile. Tumor‐associated macrophages (TAMs) are among the most abundant immune cells in the TME, shown to be linked to poor prognosis and therapeutic ...

    • Behovsmedisinering i sykehjem: Forskrivning, bruk og dokumentasjon av effekt. 

      Rønningen, Stine Wang; Bakken, Kjersti; Granås, Anne Gerd (Journal article; Tidsskriftartikkel; Peer reviewed, 2013)
      Bakgrunn: For å sikre sykehjems-pasienter effektiv og forsvarlig legemiddelbehandling, kreves hensiktsmessige rutiner for forskrivning, håndtering og effektdokumentasjon både av legemidler gitt fast og ved behov. Vår kunnskap om forholdene rundt behovsmedisinering er begrenset. Hensikt: Få kunnskap om behovsmedisinering ved å kartlegge forskrivning og utlevering av behovslegemidler ved ett utvalgt ...

    • The benefit of a mechanical needle stimulation pad in patients with chronic neck and lower back pain: two randomized controlled pilot studies 

      Hohmann, Claudia; Ullrich, Isabella; Lauche, Romy; Choi, Kyung-Eun; Lüdtke, Rainer; Rolke, Rainer; Cramer, Holger; Saha, Felix Joyonto; Rampp, Thomas; Michalsen, Andreas; Langhorst, Jost; Dobos, Gustav J.; Musial, Frauke (Journal article; Tidsskriftartikkel; Peer reviewed, 2012)
      The objective was to investigate whether a treatment with a needle stimulation pad (NSP) changes perceived pain and/or sensory thresholds in patients with chronic neck (NP) and lower back pain (BP). Methods. 40 patients with chronic NP and 42 patients with chronic BP were equally randomized to either treatment or waiting list control group. The treatment group selfadministered a NSP over a period ...

    • Betydelsen av teori- och metodutvecklingen inom historieskrivningen för undervisningen i ämnet teknikhistoria 

      Wråkberg, Urban (Journal article; Tidsskriftartikkel; Peer reviewed, 1990)

    • Bicaudal D1 impairs autophagosome maturation in chronic obstructive pulmonary disease 

      Mercado, Nicolas; Colley, Thomas; Baker, Jonathan R.; Vuppussetty, Chaitanya; Kono, Yuta; Clarke, Colin; Tooze, Sharon A; Johansen, Terje; Barnes, Peter J. (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-09-26)
      Bicaudal D1 (BICD1), an adaptor for the dynein‐dynactin motor complex, has been identified as a susceptibility gene in chronic obstructive pulmonary disease (COPD). Autophagy, an essential cellular homeostasis process, is defective in COPD, in which oxidative stress‐induced misfolded proteins accumulate into toxic aggregates dependent on the accumulation of the autophagic cargo receptor p62. Defective ...

    • Binding site of ABC transporter homology models confirmed by ABCB1 crystal structure 

      Ravna, Aina W.; Sylte, Ingebrigt; Sager, Georg (Journal article; Tidsskriftartikkel; Peer reviewed, 2009-09-04)
      The human ATP-binding cassette (ABC) transporters ABCB1, ABCC4 and ABCC5 are involved in resistance to chemotherapeutic agents. Here we present molecular models of ABCB1, ABCC4 and ABCC5 by homology based on a wide open inward-facing conformation of <i>Escherichia coli</i> MsbA, which were constructed in order to elucidate differences in the electrostatic and molecular features of their drug ...

    • Biochemical and Cellular Characterization of the Function of Fluorophosphonate-Binding Hydrolase H (FphH) in Staphylococcus aureus Support a Role in Bacterial Stress Response 

      Fellner, Matthias; Walsh, Annabel; Ahator, Stephen Dela; Aftab, Nadia; Sutherland, Ben; Tan, Eng W; Bakker, Alexander T; Martin, Nathaniel I; van der Stelt, Mario; Lentz, Christian Stephan (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-10-12)
      The development of new treatment options for bacterial infections requires access to new targets for antibiotics and antivirulence strategies. Chemoproteomic approaches are powerful tools for profiling and identifying novel druggable target candidates, but their functions often remain uncharacterized. Previously, we used activity-based protein profiling in the opportunistic pathogen Staphylococcus ...

    • Biodistribution of Poly(alkyl cyanoacrylate) Nanoparticles in Mice and Effect on Tumor Infiltration of Macrophages into a Patient-Derived Breast Cancer Xenograft 

      Pandya, Abhilash D.; Iversen, Tore Geir; Moestue, Siver Andreas; Grinde, Maria Tunset; Mørch, Ýrr Asbjørg; Snipstad, Sofie; Åslund, Andreas; Øy, Geir Frode; Kildal, Wanja; Engebråten, Olav; Sandvig, Kirsten; Skotland, Tore; Mælandsmo, Gunhild Mari (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-04-28)
      We have investigated the biodistribution and tumor macrophage infiltration after intravenous injection of the poly(alkyl cyanoacrylate) nanoparticles (NPs): PEBCA (poly(2-ethyl-butyl cyanoacrylate), PBCA (poly(n-butyl cyanoacrylate), and POCA (poly(octyl cyanoacrylate), in mice. These NPs are structurally similar, have similar PEGylation, and have previously been shown to give large variations in ...

    • Biological rhythms in Arctic vertebrates. 

      Van Oort, B.E.H.; Tyler, N.J.C.; Reierth, Eirik; Stokkan, K.-A. (Journal article; Peer reviewed; Tidsskriftartikkel, 2000)

    • Biological stain collection – Absorbing paper is superior to cotton swabs 

      Janssen, Kirstin; Aune, Marthe; Olsen, Marita; Olsen, Gunn-Hege; Berg, Thomas (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-10-14)
      Biological evidence at crime scenes often contains very small amounts of DNA. Therefore, it is important to use the most effective sampling devices and procedures for stain collection. Currently, cotton swabs moistened with water are widely used, also in our laboratory. However, several studies have shown that other methods may be more efficient.<p> <p>In this study, we compared the DNA sampling ...

    • Biosynthesis of Promatrix Metalloproteinase-9/Chondroitin Sulphate Proteoglycan Heteromer Involves a Rottlerin-Sensitive Pathway 

      Malla, Nabin; Berg, Eli; Moens, Ugo; Uhlin-Hansen, Lars; Winberg, Jan-Olof (Journal article; Tidsskriftartikkel; Peer reviewed, 2011)
      Background: Previously we have shown that a fraction of the matrix metalloproteinase-9 (MMP-9) synthesized by the macrophage cell line THP-1 was bound to a chondroitin sulphate proteoglycan (CSPG) core protein as a reduction sensitive heteromer. Several biochemical properties of the enzyme were changed when it was bound to the CSPG. <br>Methodology/Principal Findings: By use of affinity chromatography, ...

    • Birth Weight, Breast Cancer and the Potential Mediating Hormonal Environment 

      Bukowski, Radek; Chlebowski, Rowan; Thune, Inger; Furberg, Anne-Sofie; Hankins, Gary; Malone, Fergal; D'Alton, Mary (Journal article; Tidsskriftartikkel; Peer reviewed, 2012)
      Previous studies have shown that woman’s risk of breast cancer in later life is associated with her infants birth weights. The objective of this study was to determine if this association is independent of breast cancer risk factors, mother’s own birth weight and to evaluate association between infants birth weight and hormonal environment during pregnancy. Independent association would have ...

    • Bisphenol A replacement chemicals, BPF and BPS, induce protumorigenic changes in human mammary gland organoid morphology and proteome 

      Winkler, Juliane; Liu, Pengyuan; Phong, Kiet; Hinrichs, Johanna H.; Ataii, Nassim; Williams, Katherine; Hadler-Olsen, Elin Synnøve; Samson, Susan; Gartner, Zev J.; Fisher, Susan; Werb, Zena (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-03-09)
      Environmental chemicals such as bisphenol A (BPA) are thought to contribute to carcinogenesis through their endocrine-disrupting properties. Due to accumulating evidence about negative human health effects, BPA is being phased out, but in parallel, exposures to replacement chemicals such as bisphenol S (BPS) and bisphenol F (BPF) are increasing. Little is known about their biologic effects, but ...

    • BKV Agnoprotein Interacts with alpha-Soluble N-Ethylmaleimide-Sensitive Fusion Attachment Protein, and Negatively Influences Transport of VSVG-EGFP 

      Johannessen, Mona; Walquist, Mari; Gerits, Nancy; Dragset, Marte Singsås; Spang, Anne; Moens, Ugo (Journal article; Tidsskriftartikkel; Peer reviewed, 2011)
      The human polyomavirus BK (BKV) infects humans worldwide and establishes a persistent infection in the kidney. The BK virus genome encodes three regulatory proteins, large and small tumor-antigen and the agnoprotein, as well as the capsid proteins VP1 to VP3. Agnoprotein is conserved among BKV, JC virus (JCV) and SV40, and agnoprotein-deficient mutants reveal reduced viral propagation. Studies with ...

    • Blood pressure, cardiorespiratory fitness and body mass : results from the Tromsø activity study 

      Wilsgaard, Tom; Furberg, Anne-Sofie (Journal article; Tidsskriftartikkel; Peer reviewed, 2011)