I dette kartleggingsprosjektet ble analysert konsentrasjonene til en lang rekke uorganiske og organiske miljøgifter, som metaller, organotinn, polysykliske aromatiske hydrokarboner, polyklorerte bifenyler og metabolitter, klorerte parafiner, klororganiske pesticider og andre pesticider, per- og polyfluoralkylstoffer, deklorane pluss, oktaklorostyren, organofosfor flammehemmere, bromerte flammehemmere, ...

Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) has been declared a global pandemic. Our goal was to determine whether co-infections with respiratory polyomaviruses, such as Karolinska Institutet polyomavirus (KIPyV) and Washington University polyomavirus (WUPyV) occur in SARS-CoV-2 infected patients. Oropharyngeal swabs from 150 individuals, 112 symptomatic COVID-19 patients and 38 ...

I Norge er det enighet om de overordnede kriteriene for å gi diagnosen løsemiddelskade. Likevel er det ikke utviklet en enhetlig og detaljert modell for utredning av slik skade. Nasjonalt kunnskapssenter for helsetjenesten har i samarbeid med de norske utredningsmiljøene for løsemiddelskade gjennomført et litteratursøk etter kliniske studier av personer med langvarig yrkesbetinget løsemiddeleksponering. ...

Mesenchymal stromal cells (MSCs), given their regenerative potential, are being investigated as a potential therapeutic tool for cartilage lesions. MSCs express several bioactive molecules which act in a paracrine fashion to modulate the tissue microenvironment. Yet, little is known about the divergence of these signalling molecules in different MSC populations. The present study investigated ...

Our aim was to examine associations between leisure time physical activity and risk of non-vertebral fractures in men and women aged ≥55 years, with focus on the anatomical fracture location. Self-reported physical activity was registered in 3,450 men and 4,072 women aged 55–97 years at baseline in the Tromsø Study, Norway, in 1994–1995. Non-vertebral fractures were registered through December 31, ...

Acute myeloid leukemia (AML) is a heterogeneous, complex, and deadly disease, whose treatment has hardly evolved for decades and grounds on the use of intensive chemotherapy regimens. Chemotherapy helps reduce AML bulk, but promotes relapse in the long-run by selection of chemoresistant leukemia stem cells (LSC). These may diversify and result in progression to more aggressive forms of AML. <i>In ...

Objectives. To gain knowledge on toxic elements in semi-domesticated reindeer and their distribution in meat, liver, tallow and bone marrow. The correlations between concentrations in meat and liver, as well as the use of the latter as an indicator for toxic elements in meat, were also investigated. Study design. Cross-sectional study on population of semi-domesticated reindeer from 2 northern ...

This study explores a new approach to pharmacophore screening involving the use of an optimized linear combination of models instead of a single hypothesis. The implementation and evaluation of the developed methodology are performed for a complete known chemical space of 5-HT1AR ligands (3616 active compounds with Ki < 100 nM) acquired from the ChEMBL database. Clusters generated from three different ...