• CCL17/TARC and CCR4 expression in Merkel cell carcinoma 

      Rasheed, Kashif; Abdulsalam, Ibrahim Afolabi; Fismen, Silje; Grimstad, Øystein; Sveinbjørnsson, Baldur; Moens, Ugo (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-07-31)
      Merkel cell carcinoma (MCC) is a rare, highly aggressive neuroendocrine skin cancer. In more than 80% of the cases, Merkel cell polyomavirus (MCPyV) is a causal factor. The oncogenic potential of MCPyV is mediated through its viral oncoproteins, large T antigen (LT) and small t antigen (sT). To investigate the role of cytokines in MCC, a PCR array analysis for genes encoding inflammatory cytokines ...
    • Promoter activity of Merkel cell Polyomavirus variants in human dermal fibroblasts and a Merkel cell carcinoma cell line. 

      Abdulsalam, Ibrahim Afolabi; Rasheed, Kashif; Sveinbjørnsson, Baldur; Ehlers, Bernhard; Moens, Ugo (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-04-19)
      <p><i>Background - </i>Merkel cell polyomavirus (MCPyV) is a human polyomavirus that establishes a life-long harmless infection in most individuals, with dermal fibroblasts believed to be the natural host cell. However, this virus is the major cause of Merkel cell carcinoma (MCC), an aggressive skin cancer. Several MCPyV variants with polymorphism in their promoter region have been isolated, but it ...