Søk
Viser treff 1-10 av 13
High expression of PDGFR-β in prostate cancer stroma is independently associated with clinical and biochemical prostate cancer recurrence
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-02-24)
Due to a lack of sufficient diagnostic tools to predict aggressive disease, there is a significant overtreatment of patients with prostate cancer. Platelet derived growth factors (PDGFs) and their receptors (PDGFRs) are key regulators of mesenchymal cells in the tumor microenvironment, and has been associated with unfavorable outcome in several other cancers. Herein, we aimed to investigate the ...
Evaluation of the proliferation marker Ki-67 in a large prostatectomy cohort.
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-11-15)
The tumor proliferation index marker Ki-67 is strongly associated with tumor cell proliferation,
growth and progression, and is widely used in routine clinicopathological investigation.
Prostate cancer is a complex multifaceted and biologically heterogeneous disease, and
overtreatment of localized, low volume indolent tumors, is evident. Here, we aimed to
assess Ki-67 expression and related ...
The impact of MET, IGF-1, IGF1R expression and EGFR mutations on survival of patients with non-small-cell lung cancer
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-07-25)
Introduction: <br>
To compare the efficacy of silver in situ hybridization (SISH) and immunohistochemistry (IHC) in detecting MET and IGF1R alterations and to investigate their prevalence and prognostic significance. A possible correlation between MET receptor expression, MET gene alterations and the two most frequent occurring EGFR gene mutations was also investigated.
<br>Materials and ...
Prognostic effect of intratumoral neutrophils across histological subtypes of non-small cell lung cancer
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016)
Recent data indicate that tumor-associated neutrophils (TANs) serve a dual role in tumor progression and regression. CD66b is a neutrophil marker and has been associated with patient outcome in various cancers. However, its clinical impact in non-small cell lung cancer (NSCLC) remains controversial. 536 NSCLC patients, of which 172 harbored lymph node metastases, were included in this study. Tissue ...
Estrogen receptors α and β and aromatase as independent predictors for prostate cancer outcome
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-09-09)
Androgens are considered important in normal prostate physiology and prostate cancer (PCa)
pathogenesis. However, androgen-targeted treatment preventing PCa recurrence is still lacking.
This indicates additional mediators contributing to cancer development. We sought to determine the
prognostic significance of estrogen receptors, ERα and -β, and the aromatase enzyme in PCa. Tissue
microarrays ...
Assessing PDL-1 and PD-1 in NoneSmall Cell Lung Cancer: A Novel Immunoscore Approach
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-10-05)
Novel immune biomarkers could complement the TNM classification for nonesmall cell cancer (NSCLC),
improving the prognostic accuracy. The present study evaluated the prognostic significance of the immune
checkpoint molecules programmed cell death protein 1 (PD-1) and PD-1 ligand (PD-L1) in 536 patients with stage
I to IIIA NSCLC using an Immunoscore approach. Independently, and in combination, ...
Evaluation of the proliferation marker Ki-67 in a large prostatectomy cohort
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-11-15)
The tumor proliferation index marker Ki-67 is strongly associated with tumor cell proliferation,
growth and progression, and is widely used in routine clinicopathological investigation.
Prostate cancer is a complex multifaceted and biologically heterogeneous disease, and
overtreatment of localized, low volume indolent tumors, is evident. Here, we aimed to
assess Ki-67 expression and related ...
Progesterone receptors in prostate cancer: Progesterone receptor B is the isoform associated with disease progression
(Journal article; Tidsskriftartikkel; Peer reviewed, 2018-07-27)
The role of steroid hormones in carcinogenesis of the prostate is to some extent unraveled thorough the effect of androgen deprivation therapy on prostate cancer (PCa) progression. Other members of the steroid hormone family, such as progesterone, are also implicated in PCa, but progesterone’s role remains undefined. This study aimed to examine the distribution of progesterone receptor isoforms ...
MicroRNA 141 is associated to outcome and aggressive tumor characteristics in prostate cancer
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-01-23)
A large number of miRNAs influence key cellular processes involved in prostate tumorigenesis. Previous studies have demonstrated high expression of miRNAs in human prostate cancer (PC) tissues and cell lines. In previous microarray data, we found miR-141 to be upregulated and miR-145 to be downregulated in PC. In this large PC cohort (n = 535), we explored the prognostic role of miR-141 and miR-145 ...
Prognostic Value of Macrophage Phenotypes in Resectable Non–Small Cell Lung Cancer Assessed by Multiplex Immunohistochemistry
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-02-10)
Macrophages are important inflammatory cells that regulate innate and adaptive immunity in cancer. Tumor-associated macrophages (TAMs) are thought to differentiate into two main phenotypes: proinflammatory M1 and protumorigenic M2. Currently, the prognostic impact of TAMs and their M1 and M2 phenotypes is unclear in non–small cell cancer (NSCLC). The present study was set up to evaluate an approach ...