Søk
Viser treff 1-10 av 11
MicroRNAs as potential biomarkers in Merkel cell carcinoma
(Journal article; Tidsskriftartikkel; Peer reviewed, 2018-06-26)
Merkel cell carcinoma (MCC) is a rare and aggressive type of skin cancer associated with a poor prognosis. This carcinoma was named after its presumed cell of origin, the Merkel cell, which is a mechanoreceptor cell located in the basal epidermal layer of the skin. Merkel cell polyomavirus seems to be the major causal factor for MCC because approximately 80% of all MCCs are positive for viral DNAs. ...
The role of Merkel cell polyomavirus and other human polyomaviruses in emerging hallmarks of cancer
(Journal article; Tidsskriftartikkel; Peer reviewed, 2015-04-10)
Polyomaviruses are non-enveloped, dsDNA viruses that are common in mammals,
including humans. All polyomaviruses encode the large T-antigen and small t-antigen
proteins that share conserved functional domains, comprising binding motifs for the tumor
suppressors pRb and p53, and for protein phosphatase 2A, respectively. At present,
13 different human polyomaviruses are known, and for some of them ...
Promoter activity of Merkel cell Polyomavirus variants in human dermal fibroblasts and a Merkel cell carcinoma cell line.
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-04-19)
<p><i>Background - </i>Merkel cell polyomavirus (MCPyV) is a human polyomavirus that establishes a life-long harmless infection in most individuals, with dermal fibroblasts believed to be the natural host cell. However, this virus is the major cause of Merkel cell carcinoma (MCC), an aggressive skin cancer. Several MCPyV variants with polymorphism in their promoter region have been isolated, but it ...
Inhibition of chemerin/CMKLR1 axis in neuroblastoma cells reduces clonogenicity and cell viability in vitro and impairs tumor growth in vivo
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-07-27)
Pro-inflammatory cells, cytokines, and chemokines are essential in promoting a tumor supporting microenvironment. Chemerin is a chemotactic protein and a natural ligand for the receptors CMKLR1, GPR1, and CCRL2. The chemerin/CMKLR1 axis is involved in immunity and inflammation, and it has also been implicated in obesity and cancer.<p>
In neuroblastoma, a childhood tumor of the peripheral nervous ...
SYK Inhibition Potentiates the Effect of Chemotherapeutic Drugs on Neuroblastoma Cells in Vitro
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-02-10)
Neuroblastoma is a malignancy arising from the developing sympathetic nervous system and the most common and deadly cancer of infancy. New therapies are needed to improve the prognosis for high-risk patients and to reduce toxicity and late effects. Spleen tyrosine kinase (SYK) has previously been identified as a promising drug target in various inflammatory diseases and cancers but has so far not ...
Reciprocal transactivation of Merkel cell polyomavirus and high-risk human papillomavirus promoter activities and increased expression of their oncoproteins
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-07-03)
<i>Background</i> - Approximately 15% of human cancers are attributed to viruses. Numerous studies have shown that high-risk human polyomaviruses (HR-HPV) and Merkel cell polyomavirus (MCPyV) are two human tumor viruses associated with anogenetal and oropharyngeal cancers, and with Merkel cell carcinoma, respectively. MCPyV has been found in HR-HPV positive anogenetal and oropharyngeal tumors, ...
Merkel cell polyomavirus and non-Merkel cell carcinomas: Guilty or circumstantial evidence?
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-01-28)
Merkel cell polyomavirus (MCPyV) is the major causative factor of the rare but aggressive cancer, Merkel cell carcinoma (MCC). Two characteristics of MCPyV‐positive MCCs are integration of the viral genome and expression of a truncated version of one of its oncogenic proteins, namely large T antigen. The strong association of MCPyV with MCC development has incited researchers to further investigate ...
CCL17/TARC and CCR4 expression in Merkel cell carcinoma
(Journal article; Tidsskriftartikkel; Peer reviewed, 2018-07-31)
Merkel cell carcinoma (MCC) is a rare, highly aggressive neuroendocrine skin cancer. In more than 80% of the cases, Merkel cell polyomavirus (MCPyV) is a causal factor. The oncogenic potential of MCPyV is mediated through its viral oncoproteins, large T antigen (LT) and small t antigen (sT). To investigate the role of cytokines in MCC, a PCR array analysis for genes encoding inflammatory cytokines ...
The Merkel Cell Polyomavirus T-Antigens and IL-33/ST2-IL1RAcP Axis: Possible Role in Merkel Cell Carcinoma
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-03-28)
Merkel cell polyomavirus (MCPyV) is a causal factor in Merkel cell carcinoma (MCC).
The oncogenic potential is mediated through its viral oncoproteins large T-antigen (LT) and small
T-antigen (sT). Cytokines produced by tumor cells play an important role in cancer pathogenesis,
and viruses affect their expression. Therefore, we compared human cytokine and receptor transcript
levels in virus ...
Regulation of Transcriptional Activity of Merkel Cell Polyomavirus Large T-Antigen by PKA-Mediated Phosphorylation
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-01-03)
Merkel cell polyomavirus (MCPyV) is the major cause of Merkel cell carcinoma (MCC),
an aggressive skin cancer. MCPyV large T-antigen (LTag) and small T-antigen (sTag) are the main
oncoproteins involved in MCPyV-induced MCC. A hallmark of MCPyV-positive MCC cells is the
expression of a C-terminal truncated LTag. Protein kinase A (PKA) plays a fundamental role in a
variety of biological processes, ...