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Oncolysis with DTT-205 and DTT-304 generates immunological memory in cured animals
(Journal article; Tidsskriftartikkel; Peer reviewed, 2018-10-23)
Abstract
Oncolytic peptides and peptidomimetics are being optimized for the treatment of cancer by selecting agents with
high cytotoxic potential to kill a maximum of tumor cells as well as the capacity to trigger anticancer immune
responses and hence to achieve long-term effects beyond therapeutic discontinuation. Here, we report on the
characterization of two novel oncolytic peptides, DTT-205 ...
The oncolytic peptide LTX-315 induces cell death and DAMP release by mitochondria distortion in human melanoma cells
(Journal article; Tidsskriftartikkel; Peer reviewed, 2015-10-13)
Host defense peptides (HDPs) are naturally occurring molecules found in most
species, in which they play a significant role in the first line defense against intruding
pathogens, and several HDPs have been shown to possess anticancer activity.
Structure-activity relationship studies on the HDP bovine lactoferricin revealed
a de novo design of a nonamer peptide LTX-315, with oncolytic properties.
In ...
Quiescence and gamma H2AX in neuroblastoma are regulated by ouabain/Na,K-ATPase
(Journal article; Tidsskriftartikkel; Peer reviewed, 2012)
Cellular quiescence is a state of reversible proliferation arrest that is induced by anti-mitogenic signals. The endogenous cardiac glycoside ouabain is a specific ligand of the ubiquitous sodium pump, Na,K-ATPase, also known to regulate cell growth through unknown signalling pathways.
To investigate the role of ouabain/Na,K-ATPase in uncontrolled neuroblastoma growth we used xenografts, flow ...
FITC conjugation markedly enhances hepatic clearance of N-formyl peptides
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-08-05)
In both septic and aseptic inflammation, N-formyl peptides may enter the circulation and
induce a systemic inflammatory response syndrome similar to that observed during septic
shock. The inflammatory response is brought about by the binding of N-formyl peptide to
formyl peptide receptors (FPRs), specific signaling receptors expressed on myeloid as well
as non-myeloid cells involved in the ...
The role of formyl peptide receptor 1 (FPR1) in neuroblastoma tumorigenesis
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-07-18)
Background: Formyl peptide receptor 1 (FPR1) is a G protein-coupled receptor mainly expressed by the cells of
myeloid origin, where it mediates the innate immune response to bacterial formylated peptides. High expression of
FPR1 has been detected in various cancers but the function of FPR1 in tumorigenesis is poorly understood.
Methods: Expression of FPR1 in neuroblastoma cell lines and primary ...
The cytolytic amphipathic β(2,2)-amino acid LTX-401 induces DAMP release in melanoma cells and causes complete regression of B16 melanoma
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016)
In the present study we examined the ability of the amino acid derivative LTX-401 to induce cell death in cancer cell lines, as well as the capacity to induce regression in a murine melanoma model. Mode of action studies in vitro revealed lytic cell death and release of danger-associated molecular pattern molecules, preceded by massive cytoplasmic vacuolization and compromised lysosomes in treated ...
Effect of Perioperative Dexamethasone and Different NSAIDs on Anastomotic Leak Risk: A Propensity Score Analysis
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-11)
Background
Perioperative use of nonsteroidal anti-inflammatory drugs (NSAIDs) is associated with risk of anastomotic leak (AL). However, concomitant use of other drugs could infer a bias in risk assessment. Thus, we aimed to interrogate the risk of AL associated with NSAIDs and steroids used perioperatively.
Methods
This study includes a consecutive series of patients having surgery involving ...
ERBB3 is a marker of a ganglioneuroblastoma/ganglioneuroma-like expression profile in neuroblastic tumours
(Journal article; Tidsskriftartikkel; Peer reviewed, 2013)
Background: Neuroblastoma (NB) tumours are commonly divided into three cytogenetic subgroups. However, by unsupervised principal components analysis of gene expression profiles we recently identified four distinct subgroups, r1-r4. In the current study we characterized these different subgroups in more detail, with a specific focus on the fourth divergent tumour subgroup (r4).
Methods: Expression ...
LTX-315: a first-in-class oncolytic peptide that reprograms the tumor microenvironment
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-05-08)
The oncolytic peptide LTX-315, which has been <i>de novo</i> designed based on structure–
activity relationship studies of host defense peptides, has the ability to kill human
cancer cells and induce specific anticancer immune response when injected locally into
tumors established in immunocompetent mice. The oncolytic effect of LTX-315 involves
perturbation of plasma membrane and the mitochondria ...
Oncolytic peptide LTX-315 induces an immune-mediated abscopal effect in a rat sarcoma model
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-08-17)
LTX 315 is an oncolytic peptide with potent immunological properties. In the present study, we
demonstrate that intratumoral treatment with LTX-315 resulted in a complete regression and systemic
immune response in a rat fibrosarcoma model. The treatment was T-cell dependent, and also resulted
in an abscopal effect as demonstrated by the regression of distal non-treated lesions. Significant
infiltration ...