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dc.contributor.authorGregersen, Ida
dc.contributor.authorSkjelland, Mona
dc.contributor.authorHolm, Sverre
dc.contributor.authorHolven, Kirsten Bjørklund
dc.contributor.authorSørensen, Kirsten
dc.contributor.authorRussell, David
dc.contributor.authorAskevold, Erik Tandberg
dc.contributor.authorDahl, Christen Peder
dc.contributor.authorØrn, Stein
dc.contributor.authorGullestad, Lars
dc.contributor.authorMollnes, Tom Eirik
dc.contributor.authorUeland, Thor
dc.contributor.authorAukrust, Pål
dc.contributor.authorHalvorsen, Bente
dc.date.accessioned2014-03-20T14:46:29Z
dc.date.available2014-03-20T14:46:29Z
dc.date.issued2013
dc.description.abstractObjective: Atherosclerosis is a chronic inflammatory disorder that involves a range of inflammatory mediators. Although interleukin (IL)-9 has been related to inflammation, there are at present no data on its role in atherosclerosis. Here we have examined IL-9 and IL-9 receptor (IL-9R) systemically and locally in patients with coronary and carotid atherosclerosis. Methods: Plasma IL-9 was quantified by enzyme immunoassay and multiplex technology. IL-9 and IL-9R mRNA were quantified by real-time RT-PCR, and their localization within the lesion was assessed by immunohistochemistry. Results: The main findings were: (i) Patients with carotid atherosclerosis had significantly raised IL-9 plasma levels compared with healthy controls (n = 28), with no differences between asymptomatic (n = 56) and symptomatic (n = 88) patients. (ii) On admission, patients with acute ST-elevation myocardial infarction (STEMI) (n = 42) had markedly raised IL-9 plasma levels which gradually declined during the first week post-MI. (iii) T cells and monocytes from patients with unstable angina (n = 17) had increased mRNA levels of IL-9 as compared with controls (n = 11). (iv) Carotid plaques (n = 68) showed increased mRNA levels of IL-9 and IL-9R compared to non-atherosclerotic vessels (n = 10). Co-localization to T cells (IL-9 and IL-9R) and macrophages (IL-9) were shown by immunohistochemistry. (v) IL-9 increased IL-17 release in peripheral blood mononuclear cells from patients with unstable angina (n = 5) and healthy controls (n = 5) with a particularly enhancing effect in cells from the patient group. Conclusion: Our findings show increased IL-9 levels in different atherosclerotic disorders both systemically and within the lesion, suggesting a role for the IL-9/IL-9R axis in the atherosclerotic process, potentially involving IL-17 mediated mechanisms. However, the functional consequences of these findings should be further investigated.en
dc.identifier.citationPLoS ONE (2013). vol. 8(8): e72769.en
dc.identifier.cristinIDFRIDAID 1063016
dc.identifier.doihttp://dx.doi.org/10.1371/journal.pone.0072769
dc.identifier.issn1932-6203
dc.identifier.urihttps://hdl.handle.net/10037/6004
dc.identifier.urnURN:NBN:no-uit_munin_5697
dc.language.isoengen
dc.publisherPublic Library of Science (PLoS)en
dc.rights.accessRightsopenAccess
dc.subjectVDP::Medical disciplines: 700::Clinical medical disciplines: 750::Cardiology: 771en
dc.subjectVDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Kardiologi: 771en
dc.titleIncreased Systemic and Local Interleukin 9 Levels in Patients with Carotid and Coronary Atherosclerosisen
dc.typeJournal articleen
dc.typeTidsskriftartikkelen
dc.typePeer revieweden


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