• Alginate microsphere compositions dictate different mechanisms of complement activation with consequences for cytokine release and leukocyte activation 

      Ørning, Mathias Pontus; Hoem, Kine Samseth; Coron, Abba Elizabeth; Skjåk-Bræk, Gudmund; Mollnes, Tom Eirik; Brekke, Ole Lars; Espevik, Terje; Rokstad, Anne Mari (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-03-16)
      The inflammatory potential of 12 types of alginate-based microspheres was assessed in a human whole blood model. The inflammatory potential could be categorized from low to high based on the four main alginate microsphere types; alginate microbeads, liquefied core poly-l-ornithine (PLO)-containing microcapsules, liquefied core poly-l-lysine (PLL)-containing microcapsules, and solid core PLL-containing ...
    • The All-Age Prevalence of Helicobacter pylori Infection and Potential Transmission Routes. A Population-Based Study 

      Breckan, Ragnar K; Paulssen, Eyvind Jakob; Asfeldt, Anne Mette; Kvamme, Jan-Magnus; Straume, Bjørn; Florholmen, Jon (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-05-12)
      Background and aims: Previous research on H. pylori epidemiology has mostly focused on adult populations. We have aimed to study H. pylori prevalence in all age groups including children and adolescents and to identify potential routes of transmission. Methods: Subjects from all age groups (children 0–11 years, adolescents 12–17 years and adults ≥18 years of age), recruited from both an urban ...
    • Alpha-actinin-binding antibodies in relation to systemic lupus erythematosus and lupus nephritis 

      Becker-Merok, Andrea; Kalaaji, Manar; Haugbro, Kaia; Nikolaisen, Cathrin; Nilsen, Kirsten; Rekvig, Ole Petter; Nossent, Johannes C (Journal article; Tidsskriftartikkel; Peer reviewed, 2006-10-24)
      This study investigated the overall clinical impact of anti-α- actinin antibodies in patients with pre-selected autoimmune diseases and in a random group of anti-nuclear antibody (ANA)- positive individuals. The relation of anti-α-actinin antibodies with lupus nephritis and anti-double-stranded DNA (anti-dsDNA) antibodies represented a particular focus for the study. Using a cross-sectional ...
    • Alpha-mannosidosis 

      Nilssen, Øivind; Malm, Dag (Journal article; Tidsskriftartikkel; Peer reviewed, 2008-07-23)
      Alpha-mannosidosis is an inherited lysosomal storage disorder characterized by immune deficiency, facial and skeletal abnormalities, hearing impairment, and intellectual disability. It occurs in approximately 1 of 500,000 live births. The children are often born apparently normal, and their condition worsens progressively. Some children are born with ankle equinus or develop hydrocephalus in the ...
    • Alpha-mannosidosis: Correlation between phenotype, genotype and mutant MAN2B1 subcellular localisation Inherited metabolic diseases 

      Borgwardt, Line; Stensland, Hilde Monica Frostad Riise; Olsen, Klaus Juul; Wibrand, Flemming; Klenow, Helle; Beck, Michael; Amraoui, Yasmina; Arash, Laila; Fogh, Jens; Nilssen, Øivind; Lund, Allan Meldgaard (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-06-06)
      Background: Alpha-mannosidosis is caused by mutations in MAN2B1, leading to loss of lysosomal alpha-mannosidase activity. Symptoms include intellectual disabilities, hearing impairment, motor function disturbances, facial coarsening and musculoskeletal abnormalities. <p>Methods: To study the genotype-phenotype relationship for alpha-mannosidosis 66 patients were included. Based on the predicted ...
    • Altered pharmacological effects of adrenergic agonists during hypothermia 

      Dietrichs, Erik Sveberg; Sager, Georg; Tveita, Torkjel (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-12-05)
      Rewarming from accidental hypothermia is often complicated by hypothermia-induced cardiac dysfunction, calling for immediate pharmacologic intervention. Studies show that although cardiac pharmacologic support is applied when rewarming these patients, a lack of updated treatment recommendations exist. Mainly due to lack of clinical and experimental data, neither of the international guidelines ...
    • Ambulance helicopter contribution to search and rescue in North Norway 

      Glomseth, Ragnar; Gulbrandsen, Fritz I.; Fredriksen, Knut (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-09-13)
      Background: Search and rescue (SAR) operations constitute a significant proportion of Norwegian ambulance helicopter missions, and they may limit the service’s capacity for medical operations. We compared the relative contribution of the different helicopter resources using a common definition of SAR-operation in order to investigate how the SAR workload had changed over the last years. Methods: We ...
    • Anaemia and thrombocytopenia in patients with prostate cancer and bone metastases 

      Haukland, E; Nieder, Carsten; Pawinski, Adam; Dalhaug, Astrid (Journal article; Tidsskriftartikkel; Peer reviewed, 2010)
    • Anal incontinence, urinary incontinence and sexual problems in primiparous women - a comparison between women with episiotomy only and women with episiotomy and obstetric anal sphincter injury 

      Stedenfeldt, Mona; Pirhonen, Jouko; Blix, Ellen; Wilsgaard, Tom; Vonen, Barthold; Øian, Pål (Journal article; Tidsskriftartikkel; Peer reviewed, 2014)
    • Analysing mHealth usage logs in RCTs: Explaining participants’ interactions with type 2 diabetes self-management tools 

      Bradway, Meghan; Pfuhl, Gerit; Joakimsen, Ragnar Martin; Ribu, Lis; Grøttland, Astrid; Årsand, Eirik (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-08-30)
      <p><i>Background</i>: The Introduction of mobile health (mHealth) devices to health intervention studies challenges us as researchers to adapt how we analyse the impact of these technologies. For interventions involving chronic illness self-management, we must consider changes in behaviour in addition to changes in health. Fortunately, these mHealth technologies can record participants’ interactions ...
    • Analysis of the immune microenvironment in resected non-small cell lung cancer: The prognostic value of different T lymphocyte markers 

      Usó, Marta; Jantus-Lewintre, Eloísa; Bremnes, Roy M.; Calabuig, Silvia; Blasco, Ana; Pastor, Enrique; Borreda, Irene; Molina-Pinelo, Sonia; Paz-Ares, Luis; Guijarro, Ricardo; Martorell, Miguel; Forteza, Jerónimo; Camps, Carlos; Sirera, Rafael (Journal article; Tidsskriftartikkel; Peer reviewed, 2016)
      The prognosis of non-small cell lung cancer (NSCLC) remains poor and heterogeneous and new biomarkers are needed. As the immune system plays a pivotal role in cancer, the study of immune-related markers may provide valuable prognostic information of NSCLC. In 122 formalin-fixed, paraffin-embedded tumor tissue samples from early-stage NSCLC, tumor and tumor-near stromal areas were microdissected and ...
    • Anti-type II collagen antibodies, anti-CCP, IgA RF and IgM RF are associated with joint damage, assessed eight years after onset of juvenile idiopathic arthritis (JIA) 

      Berntson, Lillemor; Nordal, Ellen Berit; Fasth, Anders; Aalto, Kristiina; Herlin, T; Nielsen, Susan; Rygg, Marite; Zak, M; Ronnelid, J (Journal article; Tidsskriftartikkel; Peer reviewed, 2014)
    • Antibiotic treatment In patients with chronic low back pain and Modic changes (the AIM study): study protocol for a randomised controlled trial. 

      Storheim, Kjersti; Espeland, Ansgar; Grøvle, Lars; Skouen, Jan Sture; Assmus, Jörg; Anke, Audny; Froholdt, Anne; Pedersen, Linda Margareth; Haugen, A. J.; Fors, Terese; Lutro, Olav; Marchand, Gunn Hege; Kadar, Thomas; Vetti, Nils; Randen, Solfrid; Nygaard, Øystein Petter; Brox, Jens Ivar; Grotle, Margreth; Zwart, John-Anker (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-12-15)
      Background: <br>A previous randomised controlled trial (RCT) of patients with chronic low back pain (LBP) and vertebral bone marrow (Modic) changes (MCs) on magnetic resonance imaging (MRI), reported that a 3-month, high-dose course of antibiotics had a better effect than placebo at 12 months’ follow-up. The present study examines the effects of antibiotic treatment in chronic LBP patients with ...
    • Antibody-based targeting of alternatively spliced tissue factor: A new approach to impede the primary growth and spread of pancreatic ductal adenocarcinoma 

      Unruh, Dusten; Ünlü, Betü; Lewis, Clayton S.; Qi, Xiaoyang; Chu, Zhengtao; Sturm, Robert; Keil, Ryan; Ahmad, Syed A.; Sovershaev, Timofey; Adam, Mariette; Van Dreden, Patrick; Woodhams, Barry J.; Ramchandani, Divya; Weber, Georg F.; Rak, Janusz W.; Wolberg, Alisa S.; Mackman, Nigel; Versteeg, Henri H.; Bogdanov, Vladimir Y. (Journal article; Tidsskriftartikkel; Peer reviewed, 2016)
      Alternatively spliced Tissue Factor (asTF) is a secreted form of Tissue Factor (TF), the trigger of blood coagulation whose expression levels are heightened in several forms of solid cancer, including pancreatic ductal adenocarcinoma (PDAC). asTF binds to β1 integrins on PDAC cells, whereby it promotes tumor growth, metastatic spread, and monocyte recruitment to the stroma. In this study, we determined ...
    • Antimicrobial susceptibility and body site distribution of community isolates of coagulase-negative staphylococci 

      Cavanagh, Jorunn Pauline; Wolden, Runa; Heise, Philipp; Esaiassen, Eirin; Klingenberg, Claus; Aarag, Elizabeth (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-09-07)
      The primary aim of this study was to determine antimicrobial resistance in coagulase-negative staphylococci (CoNS) from healthy adults in the community. Healthy adults (n = 114) were swabbed on six body sites; both armpits, both knee pits and both sides of the groin. Species determination was performed using Matrix Assisted Laser Desorption Ionization – Time of Flight (MALDI-TOF) and susceptibility ...
    • Antioxidant activity of selected natural medicine used in Nepal 

      Basnet, Purusotam; Baral, Kalpana Parajuli (Journal article; Tidsskriftartikkel; Peer reviewed, 2013)
      Diminished antioxidant defence or increased production of reactive oxygen and nitrogen species in the biological system can result into oxidative stress which can cause damage to deoxyribonucleic acid (DNA), proteins, lipids and as a result different disease states arise like cancer, neurodegenerative diseases, rheumatoid arthritis. Antioxidants from different plant resources can significantly delay ...
    • Antiretroviral treatment reverses HIV-associated anemia in rural Tanzania 

      Johannessen, Asgeir; Naman, Ezra; Gundersen, Svein Gunnar; Bruun, Johan Nikolai (Journal article; Tidsskriftartikkel; Peer reviewed, 2011)
      HIV-associated anemia is common and associated with poor prognosis. However, its response to antiretroviral treatment (ART) in rural Africa is poorly understood. HIV-infected adults (≥15 years) who enrolled in HIV care at Haydom Lutheran Hospital in northern Tanzania were included in the study. The effect of ART (zidovudine/stavudine + lamivudine + efavirenz/nevirapine) on HIV-associated anemia ...
    • The apolipoprotein C-I content of very-low-density lipoproteins is associated with fasting triglycerides, postprandial lipemia, and carotid atherosclerosis 

      Hansen, John-Bjarne; Fernandes, Jose A.; Notø, Ann-Trude With; Degushi, Hiroshi; Bjørkegren, Johan; Mathiesen, Ellisiv B. (Journal article; Tidsskriftartikkel; Peer reviewed, 2011)
      Experimental studies in animals suggest that apolipoprotein (apo) C-I is an important regulator of triglycerides in fasting and postprandial conditions and associated with carotid atherosclerosis. Methods. A cross-sectional study was conducted with 81 subjects, aged 56–80 years recruited from a population health survey. The participants underwent a fat tolerance test (1 g fat per Kg body weight) and ...
    • Appendix E Telemedisinske løsninger i maritime operasjoner og redningstjeneste 

      Woldaregay, Ashenafi Zebene; Hartvigsen, Gunnar; Walderhaug, Ståle (Research report; Forskningsrapport, 2016)
      Folk som jobber i maritime miljø har ikke enkel tilgang til sentrale helsetjenester, og det gjelder spesielt for sjøfolk som arbeider i arktiske områder. Selv om telemedisin har vært en suksess på land, har telemedisin kun i begrenset grad blitt tatt i bruk til havs. Dette skyldes blant annet fravær av gode kommunikasjonsløsninger, dårlige værforhold, store avstander og lange perioder utenfor ...
    • Approaching a collaborative research agenda for health systems performance in circumpolar regions 

      Chatwood, Susan; Bytautas, Jessica; Darychuk, Anthea; Bjerregaard, Peter; Brown, Adalsteinn; Cole, Donald; Hu, Howard; Jong, Micheal; King, Malcolm; Kvernmo, Siv; Veillard, Jeremy (Journal article; Tidsskriftartikkel; Peer reviewed, 2013)
      Health care in Canada's north and circumpolar regions faces considerable challenges with the remote and widely dispersed population, harsh environmental conditions, and human resource challenges. Despite per capita expenditures that are among the highest in the world, health outcomes continue to lag behind the rest of Canada, and health disparities between the Indigenous and non-Indigenous populations ...