Aim: Humour is seen as a health-promoting coping strategy when dealing with life stress. The aim is to elucidate how adult cancer survivors experience and evaluate the significance of humour in daily life, from diagnosis through their entire illness trajectory, and to gain a broader understanding of humour as part of stress-coping processes during the experience of cancer as a life-threatening ...

Accumulating evidence supports the notion that high-dose (>5 Gy) radiotherapy (RT) regimens are triggering stronger pro-immunogenic effects than standard low-dose (2 Gy) regimens. However, the effects of RT on certain immunoregulatory elements in tumors remain unexplored. In this study, we have investigated the effects of high-dose radiotherapy (HD-RT) on the immunomodulating functions of cancer-associated ...

<i>Background</i>: With recent changes in legislation regulating recreational and medical cannabis use around the globe, increased use in pregnancy is to be expected.<p> <p><i>Objectives</i>: To investigate the association between cannabis use during pregnancy and birth outcomes. <p> <p><i>Method</i>: Data from the Norwegian Mother and Child Cohort Study (MoBa), a prospective pregnancy cohort, ...

Keratinocytes and remnant of keratinocytes in nodules, abscesses, and sinus tracts are radically removed in surgical treatment of hidradenitis suppurativa.1 We are now using methylene blue in carbon dioxide laser surgery for patients with moderate to severe hidradenitis lesions (Hurley stage II-III). Methylene blue stains active inflammatory nodules and sinus tracts. We use a modified methylene blue ...

<i>Background</i> - Cardiorespiratory fitness (CRF) is a strong predictor of future arterial cardiovascular disease and premature mortality. However, there are limited data on the association between CRF and the risk of incident venous thromboembolism (VTE).<p><p> <i>Objectives</i> - To investigate whether estimated CRF (eCRF) was associated with the risk of incident VTE in a cohort recruited ...

Aim: The aim of this study was to explore experiences with overnight respite care (ORC) of Norwegian carers who provided care to frail elderly awaiting nursing home placement. <br> Background: In many Western countries respite care has become part of health care service provision, and various types of respite care are available. The intent with respite care can be twofold; caring for the care ...

Background Information on cause of death may help appraise the degree to which the high excess mortality after hip fracture refects pre-existing comorbidities or the injury itself. We aimed to describe causes of death and causespecifc excess mortality through the frst year after hip fracture.<p> <p>Methods For studying the distribution of causes of death by time after hip fracture, we calculated ...

<b>Introduction</b> <br> Rituximab (RTX) is a B cell-depleting agent approved for the treatment of granulomatosis with polyangiitis (GPA). RTX reduces antibody producing precursor plasma cells and inhibits B and T cells interaction. Infections related to T cell immunodeficiency are not infrequent during RTX treatment. Our study investigated CD4 cell count and CD4/CD8 ratio in GPA patients during the ...

Intestinal fibrosis is a major complication of the inflammatory bowel diseases (IBD) and although inflammation is necessary for its development, it would appear that it plays a minor role in its progression as anti-inflammatory treatments in IBD do not prevent fibrosis once it has started. The processes that regulate fibrosis would thus appear to be distinct from those regulating inflammation and, ...

<i>Background</i> - Centralization of pancreatic surgery is currently called for owing to superior outcomes in higher‐volume centres. Conversely, organizational and patient concerns speak for a moderation in centralization. Consensus on the optimal balance has not yet been reached. This observational study presents a volume–outcome analysis of a complete national cohort in a health system with ...