Severe ulcerative colitis (UC) is a potentially life-threatening disease with a potential colorectal cancer (CRC) risk. The aim of this study was to explore the relationship between transcriptomic and genome-wide DNA methylation profiles in a well-stratified, treatment-naïve severe UC patient population in order to define specific epigenetic changes that could be responsible for the grade of disease ...

<p><i>Background</i>: Few biological markers are associated with survival after relapse of B-cell precursor acute lymphoblastic leukemia (BCP-ALL). In pediatric T-cell ALL, we have identified promoter-associated methylation alterations that correlate with prognosis. Here, the prognostic relevance of CpG island methylation phenotype (CIMP) classification was investigated in pediatric BCP-ALL ...

Introduction: The National Advisory Committee on Aeronautics’ (NACA) severity score is widely used in pre-hospital emergency medicine to grade the severity of illness or trauma in patient groups but is scarcely validated. The aim of this study was to assess the score’s ability to predict mortality and need for advanced in-hospital interventions in a cohort from one anaesthesiologistmanned helicopter ...

Introduction and hypothesis: The aims were to establish the prevalence of sexually abstinent women because of Pelvic Floor Disorders (PFDs) in parous women, and to examine if abstinence was associated with symptoms of PFDs or functional anatomy of the pelvic floor. Methods: Cross-sectional study of parous women responding to a questionnaire and undergoing pelvic floor examination. Distress for ...

Introduction <br>Nearly 40% of patients with advanced NSCLC are in performance status (PS) 2. These patients have a shorter life expectancy than PS 0/1 patients and they are underrepresented in clinical trials. Data on how platinum-based combination chemotherapy affects Health Related Quality of Life (HRQOL) of patients with PS 2 are scarce and the treatment of this important group of patients is ...

<i>Objective</i>: Our study aimed to verify whether cyberbullying victimization among adolescents occurs concomitantly with other forms of violence exposure (at home, at school and in the community).<p> <p><i>Methods</i>: A collaborative longitudinal study by Norwegian and Brazilian researchers was conducted in Itaboraí, a low-income city in southeast Brazil. At baseline, trained interviewers ...

Aims. To evaluate whether reduced waiting time influences survival of patients treated with whole-brain radiotherapy (WBRT) for brainmetastases. Materials and Methods. Retrospective intention-to-treat study including 110 patients treated with primary WBRT (typically 10 fractions of 3Gy; no other treatment between diagnosis and WBRT). Uni- and multivariate tests were performed. Results. Median ...

The doctor-patient relationship has been the cornerstone of medical practice. As e-health is coming to play an increasingly important role, it is necessary to consider how e-health can draw on, integrate and safeguard aspects of this relationship and thereby improve services and engage patients.

The host is protected by pattern recognition systems, including complement and TLRs, which are closely cross-talking. If improperly activated, these systems might induce tissue damage and disease. Inhibition of single downstream proinflammatory cytokines, such as TNF, IL-1β, and IL-6, have failed in clinical sepsis trials, which might not be unexpected, given the substantial amounts of mediators ...