Blar i tittel Artikler, rapporter og annet (klinisk medisin)

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    • Endothelin-1 Stimulates Monocytes in vitro to Release Chemotactic Activity Identified as Interleukin-8 and Monocyte Chemotactic Protein-1 

      Helset, E.; Sildnes, T.; Konopski, Z. S. (Journal article; Tidsskriftartikkel; Peer reviewed, 1994)
      In the present study we examined whether endothelin-1 stimulation of human monocytes causes release of chemotactic factors. It was found that monocytes released neutrophil- and monocyte-chemotactic activity in a dose- and time-dependent manner in response to ET-1. ET-1 did not show any chemotactic activity by itself. NCA was detected in monocyte supernatants in response to ET-1 (0.01–100 nM) after ...

    • Endotoxin removal in septic shock with the Alteco LPS Adsorber was safe but showed no benefit compared to placebo in the double-blind randomized controlled trial - the Asset Study 

      Lipcsey, Miklos; Tenhunen, Jyrki; Pischke, Soeren; Kuitunen, Anne; Flaatten, Hans; De Geer, Lina; Sjölin, Jan; Frithiof, Robert; Chew, Michelle S.; Bendel, Stepani; Kawati, Rafael; Larsson, Anders; Mollnes, Tom Eirik; Tønnessen, Tor Inge; Rubertsson, Sten (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-08)
      <i>Purpose</i>: Lipopolysaccharides (LPS) are presumed to contribute to the inflammatory response in sepsis. We investigated if extracorporeal Alteco LPS Adsorber for LPS removal in early gram-negative septic shock was feasible and safe. Also, effects on endotoxin level, inflammatory response, and organ function were assessed.<br><br> <i>Methods</i>: A pilot, double-blinded, randomized, Phase ...

    • Endringer i forskningsaktiviteten ved Universitetssykehuset Nord-Norge 2000 - 2005 

      Eriksen, Bjørn Odvar; Evensen, Elin Kristin (Journal article; Tidsskriftartikkel; Peer reviewed, 2006)
      Bakgrunn: Norsk medisinsk forskning hevder seg dårlig i nordisk sammenheng. Ved UniversitetssykehusetNord-Norge (UNN) ble forskningsaktivitet og hindringer for klinisk forskning undersøktmed en spørreskjemaundersøkelse i år 2000. Denne undersøkelsen er nå gjentatt etter fem år for å se omforholdene er endret.Materiale og metode: Alle leger og psykologer ved UNN fikk i mai 2005 tilsendt det samme ...

    • Epidemiology and Antimicrobial Susceptibility of Invasive Bacterial Infections in Children—A Population-Based Study From Norway 

      Thaulow, Christian Magnus; Lindemann, Paul Christoffer; Klingenberg, Claus; Berild, Dag; Blix, Hege Salvesen; Myklebust, Tor Åge; Harthug, Stig (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-05)
      Objective: To describe epidemiology and antimicrobial susceptibility testing (AST) data of bacteria causing invasive infections in Norwegian children (0–18 years).<p> <p>Methods: Population-based observational study using prospectively collected AST data from the Norwegian Surveillance System of Antimicrobial Resistance from 2013 to 2017. We included all clinically relevant bacterial isolates ...

    • Epidemiology and health related quality of life in hypoparathyroidism in Norway 

      Astor, Marianne; Løvås, Kristian; Debowska, Aleksandra; Eriksen, Erik Fink; Evang, Johan Arild; Fossum, Jan Christian; Fougner, Kristian J; Holte, Synnøve E.; Lima, Kari; Moe, Ragnar Bekkhus; Myhre, Anne Grethe; Kemp, E. Helen; Nedrebø, Bjørn Gunnar; Svartberg, Johan; Husebye, Eystein Sverre (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-05-17)
      <b>Objective:</b> The epidemiology of hypoparathyroidism (HP) is largely unknown. We aimed to determine prevalence, etiologies, health related quality of life (HRQOL) and treatment pattern of HP.<br> <b>Methods:</b> Patients with HP and 22q11 deletion syndrome (DiGeorge syndrome) were identified in electronic hospital registries. All identified patients were invited to participate in a survey. ...

    • Epidemiology and natural history in 101 subjects with FKRP-related limb-girdle muscular dystrophy R9. The Norwegian LGMDR9 cohort study (2020) 

      Jensen, Synnøve; Müller, Kai Ivar; Mellgren, Svein Ivar; Bindoff, Laurence Albert; Rasmussen, Magnhild; Ørstavik, Kristin; Jonsrud, Christoffer; Tveten, Kristian; Nilssen, Øivind; Van Ghelue, Marijke; Arntzen, Kjell Arne (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-11-25)
      We aimed to investigate the epidemiology and natural history of FKRP-related limb-girdle muscular dystrophy R9 (LGMDR9) in Norway. We identified 153 genetically confirmed subjects making the overall prevalence 2.84/100,000, the highest reported figure worldwide. Of the 153 subjects, 134 (88 %) were homozygous for FKRP c.826C>A giving a carrier frequency for this variant of 1/101 in Norway. Clinical ...

    • Epidemiology of ANCA associated vasculitis 

      Nossent, Johannes C; Koldingsnes, Wenche (Journal article; Tidsskriftartikkel; Peer reviewed, 2008)

    • The epidemiology of post-traumatic stress disorder in Norway: trauma characteristics and pre-existing psychiatric disorders 

      Lassemo, Eva Irene Samant; Sandanger, Inger; Nygård, Jan Franz; Sørgaard, Knut W. (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-10-18)
      Purpose: The prevalence of PTSD differs by gender. Pre-existing psychiatric disorders and different traumas experienced by men and women may explain this. The aims of this study were to assess (1) incidence and prevalence of exposure to traumatic events and PTSD, (2) the effect of pre-existing psychiatric disorders prior to trauma on the risk for PTSD, and (3) the effect the characteristics of trauma ...

    • Epidermal growth factor receptor signaling enhances the proinflammatory effects of staphylococcus aureus gamma-toxin on the mucosa 

      Gillman, Aaron N.; Breshears, Laura M.; Kistler, Charles K.; Finnegan, Patrick M.; Torres, Victor J.; Schlievert, Patrick M.; Peterson, Marnie L. (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-06-28)
      Staphylococcus aureus (S. aureus) produces many different exotoxins including the gamma-toxins, HlgAB and HlgCB. Gamma-toxins form pores in both leukocyte and erythrocyte membranes, resulting in cell lysis. The genes encoding gamma-toxins are present in most strains of S. aureus, and are commonly expressed in clinical isolates recovered from menstrual Toxic Shock Syndrome (mTSS) patients. This study ...

    • Epidural anesthesia and postoperative analgesia with ropivacaine and fentanyl in off-pump coronary artery bypass grafting: a randomized, controlled study 

      Kirov, Mikhail; Eremeev, Alexey; Smetkin, Alexey Anatolievich; Bjertnæs, Lars J. (Journal article; Tidsskriftartikkel; Peer reviewed, 2011)
      Our aim was to assess the efficacy of thoracic epidural anesthesia (EA) followed by postoperative epidural infusion (EI) and patient-controlled epidural analgesia (PCEA) with ropivacaine/fentanyl in off-pump coronary artery bypass grafting (OPCAB). In a prospective study, 93 patients were scheduled for OPCAB under propofol/fentanyl anesthesia and randomized to three postoperative analgesia regimens ...

    • Epipericardial Fat Necrosis: A Case Report and a Review of the Literature 

      Mortensen, Synnøve Gjelsten; Buchmann, Petr; Lappegård, Knut Tore (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-10-16)
      Epipericardial fat necrosis (EFN), also known as pericardial or mediastinal fat necrosis, has until lately been considered an unusual cause of acute chest pain. Due to increased use of computed tomography (CT) and other imaging techniques, EFN is now believed to be an under-diagnosed cause of acute chest pain. We here present a patient with a short history of acute, left-sided pleuritic chest pain ...

    • Episiotomy characteristics and risks for obstetric anal sphincter injuries: a case-control study 

      Stedenfeldt, Mona; Pirhonen, Jouko; Blix, Ellen; Wilsgaard, Tom; Vonen, Barthold; Øian, Pål (Journal article; Tidsskriftartikkel; Peer reviewed, 2012)
      Objectives  To investigate the association between the geometrical properties of episiotomy and obstetric anal sphincter injuries (OASIS) because episiotomies angled at 40–60° are associated with fewer OASIS than episiotomies with more acute angles. Design  Case–control study. Setting  University Hospital of North Norway, Tromsø and Nordland Hospital, Bodø, Norway. Sample  Seventy-four women ...

    • Er det forskjell på subkutan og intravenøs tocilizumab ved behandling av revmatoid artritt? 

      Besada, Emilio (Journal article; Tidsskriftartikkel, 2015)

    • Er legerollen uforenlig med dødshjelp? 

      Blomkvist, Andreas Wahl; Zadig, Pia Karin Karlsen; Ryssdal, Martin; Zahid, Wasim; Schei, Edvin; Nylander, Gro; Stojanovic, Filip; Solberg, Carl Tollef (Journal article; Tidsskriftartikkel; Peer reviewed, 2023)
      En problemstilling idødshjelpsdeba en er hvordan dødshjelp kan forenes etisk med rollen som helsepersonell, og spesielt med rollen som behandlende lege. Andelen leger som stø er legalisering av dødshjelp er økende, og en prosess for åavklare legens mulige oppgaver ved livets slu er derfor betimelig. Legeyrket innebærer ere faglige roller, en av dem er åvære sakkyndig. Vi skisserer en hypotetisk ...

    • Errors, Omissions, and Offenses in the Health Record of Mental Health Care Patients: Results from a Nationwide Survey in Sweden 

      Bärkås, Annika; Kharko, Anna; Blease, Charlotte; Cajander, Åsa; Fagerlund, Asbjørn Johansen; Huvila, Isto; Johansen, Monika Alise; Kane, Bridget; Kujala, Sari; Moll, Jonas; Rexhepi, Hanife; Scandurra, Isabella; Wang, Bo; Hägglund, Maria (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-11-03)
      Background: Previous research reports that patients with mental health conditions experience benefits, for example, increased empowerment and validation, from reading their patient-accessible electronic health records (PAEHRs). In mental health care (MHC), PAEHRs remain controversial, as health care professionals are concerned that patients may feel worried or offended by the content of the notes. ...

    • Establishing IMMULITE® 2000 cut-off values for serum allergen-specific immunoglobulin and exploring their relationship to exhaled nitric oxide 

      Evjenth, Bjørg; Hansen, Tonje Elisabeth; Brekke, Ole Lars; Holt, Jan (Journal article; Tidsskriftartikkel; Peer reviewed, 2014-03-31)
      Aim: Paediatric cut-off values for serum allergen-specific IgE (sIgE) using the Siemens IMMULITE 2000 system to diagnose allergic rhinoconjunctivitis have not been established. We aimed to determine cut-off levels for sIgE for 10 common inhalant allergens and to study the relationship between sIgE, total IgE and fractional exhaled nitric oxide (FENO). <br>Methods: We enrolled 243 schoolchildren, ...

    • An Estimate of the Burden of Fungal Disease in Norway 

      Nordøy, Ingvild; Hesstvedt, Liv; Andersen, Cecilie Torp; Mylvaganam, Haima; Kols, Nicola Isabelle; Falch, Birgit Margrethe; Tofteland, Ståle; Müller, Fredrik; Denning, David W. (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-02-21)
      The aim of this study was to examine the burden of fungal disease in Norway, contributing to a worldwide effort to improve awareness of the needs for better diagnosis and treatment of such infections. We used national registers and actual data from the Departments of Microbiology from 2015 and estimated the incidence and/or prevalence of superficial, allergic and invasive fungal disease using published ...

    • Estimated 8-year cumulative incidence of diabetes mellitus among Sami and non-Sami inhabitants of Northern Norway- The SAMINOR Study 

      Naseribafrouei, Ali; Eliassen, Bent Martin; Melhus, Marita; Svartberg, Johan; Broderstad, Ann Ragnhild (Journal article; Peer reviewed, 2019-06-24)
      <b>Background</b><br> The aim of the study was to estimate and compare the 8-year cumulative incidence of diabetes mellitus (DM) among Sami and non-Sami inhabitants of rural districts in Northern Norway. <br><b>Methods</b><br> Longitudinal study based on linkage of two cross-sectional surveys, the SAMINOR 1 Survey (2003–2004) and the SAMINOR 2 Clinical Survey (2012–2014). Ten municipalities in rural ...

    • Estimated and Measured GFR Associate Differently with Retinal Vasculopathy in the General Population 

      Eriksen, Bjørn Odvar; Løchen, Maja-Lisa; Arntzen, Kjell Arne; Bertelsen, Geir; Eilertsen, Britt-Ann; Hanno, Therese von; Herder, Marit; Jenssen, Trond Geir; Mathisen, Ulla Dorte; Melsom, Toralf; Njølstad, Inger; Solbu, Marit Dahl; Mathiesen, Ellisiv B. (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-11)
      Background/Aims: Estimated GFR (eGFR) is used extensively in epidemiological research. Validations of eGFR have demonstrated acceptable performance, but the dependence of creatinine and cystatin C on non-GFR factors could confound associations with disease. Few studies have investigated this issue in direct comparison with measured GFR (mGFR). We compared the associations between eGFR and mGFR ...

    • Estimated GFR is biased by non-traditional cardiovascular risk factors 

      Melsom, Toralf; Fuskevåg, Ole-Martin; Mathisen, Ulla Dorte; Strand, Harald; Schei, Jørgen; Jenssen, Trond Geir; Solbu, Marit Dahl; Eriksen, Bjørn Odvar (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-01-23)
      Background: Estimated glomerular filtration rate (eGFR) based on either cystatin C or creatinine perform similarly in estimating measured GFR, but associate differently with cardiovascular disease (CVD) and mortality. This could be due to confounding by non-GFRrelated traits associated with cystatin C and creatinine levels. We investigated non-GFRrelated associations between eGFR and two types ...