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norskBlar i tittel Artikler, rapporter og annet (klinisk medisin)
Viser treff 653-672 av 1796
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Fukutin-Related Protein Resides in the Golgi Cisternae of Skeletal Muscle Fibres and Forms Disulfide-Linked Homodimers via an N-Terminal Interaction
(Journal article; Tidsskriftartikkel; Peer reviewed, 2011)Limb-Girdle Muscular Dystrophy type 2I (LGMD2I) is an inheritable autosomal, recessive disorder caused by mutations in the FuKutin-Related Protein (FKRP) gene (FKRP) located on chromosome 19 (19q13.3). Mutations in FKRP are also associated with Congenital Muscular Dystrophy (MDC1C), Walker-Warburg Syndrome (WWS) and Muscle Eye Brain disease (MEB). These four disorders share in common an incomplete/aberrant ... -
A fully-coupled fluid-structure interaction simulation of cerebral aneurysms
(Journal article; Tidsskriftartikkel; Peer reviewed, 2010) -
Functional Analyses of Rare Germline Missense BRCA1 Variants Located within and outside Protein Domains with Known Functions
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-01-19): The BRCA1 protein is implicated in numerous important cellular processes to prevent genomic instability and tumorigenesis, and pathogenic germline variants predispose carriers to hereditary breast and ovarian cancer (HBOC). Most functional studies of missense variants in BRCA1 focus on variants located within the Really Interesting New Gene (RING), coiled-coil and BRCA1 C-terminal (BRCT) ... -
Functional recovery after accidental deep hypothermic cardiac arrest: Comparison of different cardiopulmonary bypass rewarming strategies
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-09-05)Introduction: Using a porcine model of accidental immersion hypothermia and hypothermic cardiac arrest (HCA), the aim of the present study was to compare effects of different rewarming strategies on CPB on need for vascular fluid supply, level of cardiac restitution, and cerebral metabolism and pressures.<p> <p>Materials and Methods: Totally sixteen healthy, anesthetized castrated male pigs were ... -
Functional recovery is considered the most important target: a survey of dedicated professionals
(Journal article; Tidsskriftartikkel; Peer reviewed, 2014) -
Future complications of chronic hepatitis C in a low-risk area: Projections from the hepatitis c study in Northern Norway
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-09-16)<i>Background</i>: Hepatitis C (HCV) infection causes an asymptomatic chronic hepatitis in most affected individuals, which often remains undetected until cirrhosis and cirrhosis-related complications occur. Screening of high-risk subjects in Northern Norway has revealed a relatively low prevalence in the general population (0.24%). Despite this, late complications of HCV infection are increasing. ... -
Fødselsomsorgen kan bli bedre
(Journal article; Tidsskriftartikkel, 2022-04-27)Til tross for en god fødselsomsorg i Norge skjer det uønskede hendelser med alvorlig utfall for mor og/eller barn. I media kan man jevnlig lese om alvorlige hendelser i forbindelse med fødsel, der tema ofte er dødsfall eller skade som følge av manglende eller feil helsehjelp. Disse historiene gjør inntrykk.<p> <p>Det er ikke bare den berørte familien som blir hardt rammet, det er også de involverte ... -
Fødselsstatistikken 2019
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020)Hoveddelen av dataene fra Medisinsk fødselsregister (MFR) for 2019 ble publisert i juni i år. Data om mors helse før og under svangerskapet samt data fra nyfødtavdelingene er publisert nå i desember og er tilgjengelig i vår statistikkbank. MFR har i år pga. den pågående pandemien også hatt en ekstrapublisering med et utvalg av variabler for 2020 data. Sjekk våre nettsider for mer informasjon om ... -
Førstehjelp ved skader - klart du kan!
(Chronicle; Kronikk, 2013-07-11)Radioen synger og sola skinner der du kjører bekymringsfritt langs riksveien en vakker sommerdag. Ingen biler foran deg, ingen biler bak. Plutselig ser du den, en sølvgrå Audi som står i grøfta lenger fram. Fronten er trykket inn av en stor stein. Du slår på nødblinken, og setter opp varseltrekant. Frykten for hva som kan møte deg inne i Audien slår i mellomgulvet. I førersetet sitter en ... -
GABAA subunit single nucleotide polymorphisms show sex-specific association to alcohol consumption and mental distress in a Norwegian population-based sample
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-11-14)Little is known about genetic influences on the relationship between alcohol consumption and mental distress in the general population, where the majority report consumption and distress far below diagnostic thresholds. This study investigated single nucleotide polymorphisms (SNPs) from candidate gene studies on alcohol use disorder and depressive disorders, for association with alcohol consumption ... -
GARP promotes the proliferation and therapeutic resistance of bone sarcoma cancer cells through the activation of TGF-beta
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-11-17)Sarcomas are mesenchymal cancers with poor prognosis, representing about 20% of all solid malignancies in children, adolescents, and young adults. Radio- and chemoresistance are common features of sarcomas warranting the search for novel prognostic and predictive markers. GARP/LRRC32 is a TGF-β-activating protein that promotes immune escape and dissemination in various cancers. However, if GARP ... -
Gas embolism during surgery. A complement mediated condition?
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-10-01)<p><i>Introduction</i>: Venous air embolism (VAE) may arise during surgical procedures. VAE might be complicated with a systemic inflammatory response, disseminated intervascular coagulation, multi-organ failure and cardiovascular collapse. During a short time-span, three patients at our institution developed signs of VAE in conjunction with gynecological surgery. One died, one developed severe ... -
Gender differences in association between uric acid and all-cause mortality in patients with chronic heart failure
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-01-05)<p><i>Background - </i>Elevated serum uric acid (SUA) is associated with poor prognosis in patients with cardiovascular disease, yet it is still not decided whether the role of SUA is causal or only reflects an underlying disease. The purpose of the study was to investigate if SUA was an independent predictor of 5-year all-cause mortality in a propensity score matched cohort of chronic heart failure ... -
Gene expression analyses in breast cancer epidemiology: the Norwegian Women and Cancer postgenome cohort study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2008-02-13)Introduction: The introduction of high-throughput technologies, also called -omics technologies, into epidemiology has raised the need for high-quality observational studies to reduce several sources of error and bias. Methods: The Norwegian Women and Cancer (NOWAC) postgenome cohort study consists of approximately 50,000 women born between 1943 and 1957 who gave blood samples between 2003 ... -
Gene expression profiling of Gram-negative bacteria-induced inflammation in human whole blood: The role of complement and CD14-mediated innate immune response
(Journal article; Tidsskriftartikkel; Peer reviewed, 2015-05-30)Non-sterile pathogen-induced sepsis and sterile inflammation like in trauma or ischemia–reperfusion injury may both coincide with the life threatening systemic inflammatory response syndrome and multi-organ failure. Consequently, there is an urgent need for specific biomarkers in order to distinguish sepsis from sterile conditions. The overall aim of this study was to uncover putative sepsis ... -
Generification by Translation: Designing Generic Systems in Context of the Local
(Journal article; Tidsskriftartikkel; Peer reviewed, 2014) -
Genetic interaction between the non‐homologous end joining factors during B and T lymphocyte development: in vivo mouse models
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-07-12)Non‐homologous end joining (NHEJ) is the main DNA repair mechanism for the repair of double‐strand breaks (DSBs) throughout the course of the cell cycle. DSBs are generated in developing B and T lymphocytes during V(D)J recombination to increase the repertoire of B and T cell receptors. DSBs are also generated during the class switch recombination (CSR) process in mature B lymphocytes, providing ... -
The genetic regulation of the terminating phase of liver regeneration
(Journal article; Tidsskriftartikkel; Peer reviewed, 2012)After partial hepatectomy (PHx), the liver regeneration process terminates when the normal liver-mass/body-weight ratio of 2.5% has been re-established. To investigate the genetic regulation of the terminating phase of liver regeneration, we performed a 60% PHx in a porcine model. Liver biopsies were taken at the time of resection, after three weeks and upon termination the sixth week. Gene expression ... -
Genetic Variation Of Platelet Glycoprotein VI And The Risk Of Venous Thromboembolism
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-11-07)Family studies have indicated that heritability explains 50-60% of the venous thromboembolism (VTE) events, and in recent years, several single nucleotide polymorphisms (SNPs) have been found to influence the VTE risk. Glycoprotein 6 (GP6) rs1613662, also known as T13254C, is an A/G single nucleotide variation in amino acid 219, which results in a serine to proline substitution affecting ... -
Genetic variations in the Vitamin D receptor predict type 2 diabetes and myocardial infarction in a community-based population: The tromsø study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2015-12-23)Background Though the associations between low serum 25-hydroxyvitamin D (25(OH)D) levels and health outcomes such as type 2 diabetes (T2D), myocardial infarction (MI), cancer, and mortality are well-studied, the effect of supplementation with vitamin D is uncertain. This may be related to genetic differences. Thus, rs7968585, a single nucleotide polymorphism (SNP) of the vitamin D receptor ...
