Blar i tittel Artikler, rapporter og annet (klinisk medisin)

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    • Gene expression profiling of Gram-negative bacteria-induced inflammation in human whole blood: The role of complement and CD14-mediated innate immune response 

      Lau, Corinna; Olstad, Ole Kristoffer; Holden, Marit; Nygård, Ståle; Fure, Hilde; Lappegård, Knut Tore; Brekke, Ole Lars; Espevik, Terje; Hovig, Johannes Eivind; Mollnes, Tom Eirik (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-05-30)
      Non-sterile pathogen-induced sepsis and sterile inflammation like in trauma or ischemia–reperfusion injury may both coincide with the life threatening systemic inflammatory response syndrome and multi-organ failure. Consequently, there is an urgent need for specific biomarkers in order to distinguish sepsis from sterile conditions. The overall aim of this study was to uncover putative sepsis ...

    • Generification by Translation: Designing Generic Systems in Context of the Local 

      Silsand, Line; Ellingsen, Gunnar (Journal article; Tidsskriftartikkel; Peer reviewed, 2014)

    • Genetic interaction between the non‐homologous end joining factors during B and T lymphocyte development: in vivo mouse models 

      Castaneda Zegarra, Sergio Miguel; Fernandez Berrocal, Marion Silvana; Tkachev, Max; Yao, Rouan; Esnardo Upfold, Nikki Lyn; Oksenych, Valentyn (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-07-12)
      Non‐homologous end joining (NHEJ) is the main DNA repair mechanism for the repair of double‐strand breaks (DSBs) throughout the course of the cell cycle. DSBs are generated in developing B and T lymphocytes during V(D)J recombination to increase the repertoire of B and T cell receptors. DSBs are also generated during the class switch recombination (CSR) process in mature B lymphocytes, providing ...

    • The genetic regulation of the terminating phase of liver regeneration 

      Nygård, Ingvild Engdal; Mortensen, Kim Erlend; Hedegaard, Jakob; Conley, Lene N; Kalstad, Trine; Bendixen, Christian; Revhaug, Arthur (Journal article; Tidsskriftartikkel; Peer reviewed, 2012)
      After partial hepatectomy (PHx), the liver regeneration process terminates when the normal liver-mass/body-weight ratio of 2.5% has been re-established. To investigate the genetic regulation of the terminating phase of liver regeneration, we performed a 60% PHx in a porcine model. Liver biopsies were taken at the time of resection, after three weeks and upon termination the sixth week. Gene expression ...

    • Genetic Variation Of Platelet Glycoprotein VI And The Risk Of Venous Thromboembolism 

      Skille, Hanne; Paulsen, Benedikte; Hveem, Kristian; Gabrielsen, Maiken Elvestad; Brumpton, Ben Michael; Hindberg, Kristian; Gran, Olga Vikhammer; Rosendaal, Frits Richard; Brækkan, Sigrid Kufaas; Hansen, John-Bjarne (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-11-07)
      Family studies have indicated that heritability explains 50-60% of the venous thromboembolism (VTE) events, and in recent years, several single nucleotide polymorphisms (SNPs) have been found to influence the VTE risk. Glycoprotein 6 (GP6) rs1613662, also known as T13254C, is an A/G single nucleotide variation in amino acid 219, which results in a serine to proline substitution affecting ...

    • Genetic variations in the Vitamin D receptor predict type 2 diabetes and myocardial infarction in a community-based population: The tromsø study 

      Zostautiene, Leva; Jorde, Rolf; Schirmer, Henrik; Mathiesen, Ellisiv B.; Njølstad, Inger; Løchen, Maja-Lisa; Wilsgaard, Tom; Joakimsen, Ragnar Martin; Kamycheva, Elena (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-12-23)
      Background Though the associations between low serum 25-hydroxyvitamin D (25(OH)D) levels and health outcomes such as type 2 diabetes (T2D), myocardial infarction (MI), cancer, and mortality are well-studied, the effect of supplementation with vitamin D is uncertain. This may be related to genetic differences. Thus, rs7968585, a single nucleotide polymorphism (SNP) of the vitamin D receptor ...

    • Genetically predicted cortisol levels and risk of venous thromboembolism 

      Allarai, Elias; Lee, Wei-Hsuan; Burgess, Stephen; Larsson, Susanna C.; Lindstrom, Sara; Wang, Lu; Smith, Erin N.; Gordon, William; Van Hylckama Vlieg, Astrid; De Andrade, Mariza; Brody, Jennifer A.; Pattee, Jack W.; Haessler, Jeffrey; Brumpton, Ben Michael; Chasman, Daniel I.; Suchon, Pierre; Chen, Ming-Huei; Turman, Constance; Germain, Marine; Wiggins, Kerri L.; Macdonald, James; Brækkan, Sigrid Kufaas; Armasu, Sebastian M.; Pankratz, Nathan; Jackson, Rabecca D.; Nielsen, Jonas B; Giulianini, Franco; Puurunen, Marja K.; Ibrahim, Manal; Heckbert, Susan R.; Bammler, Theo K.; Frazer, Kelly A.; Mccauley, Bryan M.; Taylor, Kent; Pankow, James S.; Reiner, Alexander P.; Gabrielsen, Maiken Elvestad; Deleuze, Jean-Francois; O'Donnell, Chris J.; Kim, Jihye; Mcknight, Barbara; Kraft, Peter; Hansen, John Bjarne; Rosendaal, Frits Richard; Heit, John A.; Psaty, Bruce M.; Tang, Weihong; Kooperberg, Charles; Hveem, Kristian; Ridker, Paul M.; Morange, Pierre-Emmanuel; Johnson, Andrew D.; Kabrhel, Christopher; Alexandretrégouët, David; Smith, Nicholas L. (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-08-19)
      Introduction - In observational studies, venous thromboembolism (VTE) has been associated with Cushing’s syndrome and with persistent mental stress, two conditions associated with higher cortisol levels. However, it remains unknown whether high cortisol levels within the usual range are causally associated with VTE risk. We aimed to assess the association between plasma cortisol levels and VTE risk ...

    • Genome-Wide DNA Methylation in Treatment-Naïve Ulcerative Colitis 

      Taman, Hagar; Fenton, Christopher Graham; Hensel, Inga Viktoria; Anderssen, Endre; Florholmen, Jon; Paulssen, Ruth H (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-08-22)
      <p><i>Background and Aims</i>: The aim of this study was to investigate the genome-wide DNA methylation status in treatment-naïve ulcerative colitis [UC], and to explore the relationship between DNA methylation patterns and gene expression levels in tissue biopsies from a well-stratified treatment-naïve UC patient group.</p> <p><i>Methods</i>; Mucosal biopsies from treatment-naïve patients [n = ...

    • Genome-wide signatures of differential DNA methylation in pediatric acute lymphoblastic leukemia 

      Nordlund, Jessica; Bäcklin, Christopher L.; Wahlberg, Per; Busche, Stephan; Berglund, Eva C.; Eloranta, Maija-Leena; Flægstad, Trond; Forestier, Erik; Frost, Britt-Marie; Harila-Saari, Arja; Heyman, Mats; Jonsson, Olafur G.; Larsson, Rolf; Palle, Josefine; Rönnblom, Lars; Schmiegelow, Kjeld; Sinnett, Daniel; Söderhäll, Stefan; Pastinen, Tomi; Gustafsson, Mats G.; Lönnerholm, Gudmar; Syvänen, Ann-Christine (Journal article; Tidsskriftartikkel; Peer reviewed, 2013-09-24)
      Background: Although aberrant DNA methylation has been observed previously in acute lymphoblastic leukemia (ALL), the patterns of differential methylation have not been comprehensively determined in all subtypes of ALL on a genome-wide scale. The relationship between DNA methylation, cytogenetic background, drug resistance and relapse in ALL is poorly understood.<p> <p>Results: We surveyed the ...

    • Genomic Sequencing and Analysis of a Novel Human Cowpox Virus With Mosaic Sequences From North America and Old World Orthopoxvirus 

      Diaz Cánova, Diana Karina; Moens, Ugo; Brinkmann, Annika; Nitsche, Andreas; Okeke, malachy ifeanyi (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-05-03)
      Orthopoxviruses (OPXVs) not only infect their natural hosts, but some OPXVs can also cause disease in humans. Previously, we partially characterized an OPXV isolated from an 18-year-old male living in Northern Norway. Restriction enzyme analysis and partial genome sequencing characterized this virus as an atypical cowpox virus (CPXV), which we named CPXV-No-H2. In this study, we determined the ...

    • Geografiske ulikheter i tilbudet av polikliniske tjenester til barn og unge ved norske sykehus - et kulturperspektiv 

      Fundingsrud, Hans Petter; Lian, Olaug S (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-05-02)
      Nasjonale kartlegginger har påvist til dels store geografiske ulikheter i tilbudet av spesialisthelsetjenester til barn og unge i Norge. Tilbudsulikhetene varierer fra tre til fem ganger for enkelte sykdomskategorier. Disse ulikhetene kan ikke forklares med forskjeller i sykelighet. Helsepolitiske målsettinger om geografisk likeverdige tjenestetilbud til befolkningen tilsier at de geografiske ...

    • Geographic variation in the utilisation of specialist healthcare for patients with severe mental illness in Norway: a population‑based registry study 

      Bedane, Haji Kedir; Lien, Lars; Holsen, Maria; Bale, Marte; Osvoll, Knut Ivar; Holman, Per Arne (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-06-27)
      Purpose - The aim of this study is to measure geographic variations in mental healthcare service utilisation among patients with severe mental illness in Norway.<p> <p>Method - We analysed data from the Norwegian patient registry for 2014–2018 for patients with severe mental illness. The outcomes measured in this study were: outpatient contact, admission, bed days and total contact rates. Total ...

    • Geographical accessibility and duration of untreated psychosis: Distance as a determinant of treatment delay 

      Kvig, Erling Inge; Brinchmann, Beate; Moe, Cathrine Fredriksen; Nilssen, Steinar; Larsen, Tor Ketil; Sørgaard, Knut W. (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-05-10)
      Background: The duration of untreated psychosis is determined by both patient and service related factors. Few studies have considered the geographical accessibility of services in relation to treatment delay in early psychosis. To address this, we investigated whether treatment delay is co-determined by straight-line distance to hospital based specialist services in a mainly rural mental health ...

    • Geographical variation in orthopedic procedures in Norway: Cross-sectional population-based study 

      Holsen, Maria; Hovind, Veronica; Bedane, Haji Kedir; Osvoll, Knut Ivar; Gjertsen, Jan-Erik; Furnes, Ove Nord; Walsh, Mary E.; Ingebrigtsen, Tor (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-09-14)
      Background: Standardized surgery rates for common orthopedic procedures vary across geographical areas in Norway. We explored whether area-level factors related to demand and supply in publicly funded healthcare are associated with geographical variation in surgery rates for six common orthopedic procedures.<p> <p>Methods: The present study is a cross-sectional population-based study of hospital ...

    • GFR in healthy aging: An individual participant data meta-analysis of iohexol clearance in european population-based cohorts 

      Eriksen, Bjørn Odvar; Pálsson, Runólfur; Ebert, Natalie; Melsom, Toralf; van der Giet, Markus; Gudnason, Vilmundur; Indridasson, Olafur S.; Inker, Lesley A.; Jenssen, Trond Geir; Levey, Andrew S.; Solbu, Marit Dahl; Tighiouart, Hocine; Schaeffner, Elke (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-07)
      <i>Background</i> - Population mean GFR is lower in older age, but it is unknown whether healthy aging is associated with preserved rather than lower GFR in some individuals.<br><br> <i>Methods</i> - We investigated the cross-sectional association between measured GFR, age, and health in persons aged 50–97 years in the general population through a meta-analysis of iohexol clearance measurements ...

    • Giving cell phones to pregnant women and improving services may increase primary health facility utilization: a case-control study of a Nigerian project 

      Oyeyemi, Sunday Oluwafemi; Wynn, Rolf (Journal article; Tidsskriftartikkel; Peer reviewed, 2014)
      Background: Worldwide, about 287 000 women die each year from mostly preventable complications related to pregnancy and childbirth. A disproportionately high number of these deaths occur in sub-Saharan Africa. The Abiye (‘Safe Motherhood’) project in the Ifedore Local Government Area (LGA) of Ondo-State of Nigeria aimed at improving facility utilization and maternal health through the use of cell ...

    • The Glasgow prognostic score: Useful information when prescribing palliative radiotherapy 

      Nieder, Carsten; Mannsåker, Bård; Dalhaug, Astrid; Pawinski, Adam; Haukland, Ellinor Christin (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-04-26)
      The purpose of the present retrospective study was to investigate whether a score reflecting systemic inflammatory processes [the Glasgow Prognostic Score (GPS)] provides relevant information for radiation oncologists. GPS is a three‑tiered score [0: normal C-reactive protein (CRP) and albumin; 1: one abnormal result; 2: increased CRP and low albumin]. Correlations between disease type and extent, ...

    • Glioblastom hos voksne 

      Schipmann, Stephanie; Sivakanesan, Sarankan; Rath, Daniel Stavne; Brandal, Petter; Vik-Mo, Einar Osland; Bjørås, Magnar; Solheim, Ole Skeidsvoll; Ingebrigtsen, Tor; Sund, Fredrik; Bjerkvig, Rolf; Miletic, Hrvoje; Johannessen, Tor-Christian Aase; Sundstrøm, Terje (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-01-30)
      Glioblastom er den vanligste formen for primær hjernekreft hos voksne, og sykdommen har en alvorlig prognose. Selv om det er gjort store fremskritt i molekylær karakteristikk, har det ikke vært større gjennombrudd i behandlingen på mange år. Vi presenterer her en klinisk oversikt over dagens diagnostikk og behandling samt hvilke utfordringer og muligheter som ligger i å utvikle bedre og mer ...

    • Glioblastoma PET/MRI: kinetic investigation of [<sup>18</sup>F]rhPSMA-7.3, [<sup>18</sup>F]FET and [<sup>18</sup>F]fluciclovine in an orthotopic mouse model of cancer 

      Lindemann, Marcel; Oteiza, Ana; Martin-Armas, Montserrat; Guttormsen, Yngve; Moldes-Anaya, Angel; Berzaghi, Rodrigo; Bogsrud, Trond; Bach-Gansmo, Tore; Sundset, Rune; Kranz, Mathias (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-11-22)
      <b><p>Purpose</b> Glioblastoma multiforme (GBM) is the most common glioma and standard therapies can only slightly prolong the survival. Neo-vascularization is a potential target to image tumor microenvironment, as it defines its brain invasion. We investigate [<sup>18</sup>F]rhPSMA-7.3 with PET/MRI for quantitative imaging of neo-vascularization in GBM bearing mice and human tumor tissue and compare ...

    • Global Characterisation of Coagulopathy in Isolated Traumatic Brain Injury (iTBI): A CENTER-TBI Analysis 

      Böhm, JK; Güting, Helge; Thorn, S; Schäfer, Nadine; Rambach, V; Schöchl, Herbert; Grottke, Oliver; Rossaint, Rolf; Stanworth, Simon; Curry, Nicola; Lefering, Rolf; Maegele, Marc; Andelic, Nada; Anke, Audny; Frisvold, Shirin; Helseth, Eirik; Røe, Cecilie; Røise, Olav; Skandsen, Toril; Vik, Anne (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-12-11)
      <i>Background</i> - Trauma-induced coagulopathy in patients with traumatic brain injury (TBI) is associated with high rates of complications, unfavourable outcomes and mortality. The mechanism of the development of TBI-associated coagulopathy is poorly understood.<br><br> <i>Methods</i> - This analysis, embedded in the prospective, multi-centred, observational Collaborative European NeuroTrauma ...