Blar i tittel Artikler, rapporter og annet (klinisk medisin)

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    • How common is substandard obstetric care in adverse events of birth asphyxia, shoulder dystocia and postpartum hemorrhage? Findings from an external inspection of Norwegian maternity units 

      Johansen, Lars Thomas; Braut, Geir Sverre; Acharya, Ganesh; Andresen, Jan Fredrik; Øian, Pål (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-07-15)
      Introduction - The Norwegian Board of Health Supervision inspects healthcare institutions to ensure safety and quality of health and welfare services. A planned inspection of 12 maternity units aimed to investigate the practice of obstetric care in the case of birth asphyxia, shoulder dystocia and severe postpartum hemorrhage.<p> <p>Material and methods - The inspection was carried out at two ...

    • How Do Elderly Poor Prognosis Patients Tolerate Palliative Concurrent Chemoradiotherapy for Locally Advanced NoneSmall Cell Lung Cancer Stage III? A Subset Analysis From a Clinical Phase III Trial 

      Strøm, Hans Henrik; Bremnes, Roy M.; Sundstrøm, Stein Harald; Helbekkmo, Nina; Aasebø, Ulf (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-05)
      In a phase III trial of patients with unresectable stage III nonesmall-cell lung cancer and a poor prognosis, palliative concurrent chemoradiotherapy (CRT) provided a significantly better outcome than chemotherapy alone, except among performance status 2 patients. The results of the present exploratory subgroup analysis indicate that elderly patients with poor prognosis can also experience ...

    • How does nursing staff perceive the use of electronic handover reports? A questionnaire-based study 

      Meum, Torbjørg; Wynn, Rolf (Journal article; Tidsskriftartikkel; Peer reviewed, 2011)

    • How mental health service systems are organized may affect the rate of acute admissions to specialized care: Report from a natural experiment involving 5338 admissions 

      Myklebust, Lars Henrik Ryther; Sørgaard, Knut W.; Wynn, Rolf (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-07-10)
      Objectives: Studies on the dynamics between service organization and acute admissions to psychiatric specialized care have given ambiguous results. We studied the effect of several variables, including service organization, coercion, and patient characteristics on the rate of acute admissions to psychiatric specialist services. In a natural experiment-like study in Norway, we compared a ...

    • How we treat octogenarians with brain metastases 

      Nieder, Carsten; Andratschke, Nicolaus H.; Grosu, Anca L. (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-08-08)
      Biologically younger, fully independent octogenarians are able to tolerate most oncological treatments. Increasing frailty results in decreasing eligibility for certain treatments, e.g., chemotherapy and surgery. Most brain metastases are not an isolated problem, but part of widespread cancer dissemination, often in combination with compromised performance status. Multidisciplinary assessment ...

    • HPV mRNA testing is more specific than HPV DNA testing in triage of women with minor cervial lesions 

      Sørbye, Sveinung Wergeland; Fismen, Silje; Gutteberg, Tore Jarl; Mortensen, Elin; Skjeldestad, Finn Egil (Conference object; Konferansebidrag, 2013)
      In Norway, repeat cytology and HPV testing is used in delayed triage of women with minor cytological lesions. Repeat cytology, HPV DNA testing (Roche Cobas 4800), and HPV mRNA testing (NorChip PreTect HPV-Proofer) were used to follow up 575 women aged 25–69 years with ASCUS / LSIL in primary screening. A total of 206 women (35.8%) were DNA+ and 107 (18.6%) were mRNA+. Repeated ASC-US / LSIL was found ...

    • HPV-testing og livmorhalskreft 

      Sørbye, Sveinung Wergeland (Journal article; Tidsskriftartikkel, 2014)
      Noen typer kreft er forårsaket av virusinfeksjoner. På verdensbasis er det beregnet at 15 % av all kreft skyldes virus. Humant papillomavirus (HPV) er årsak til 5 % av kreft, og dette viruset er påvist i kreft i blant annet livmorhals, vulva, vagina, penis, anus, tonsiller og tungebasis.

    • HPyV6 and HPyV7 in urine from immunocompromised patients 

      Prezioso, Carla; Van Ghelue, Marijke; Moens, Ugo; Pietropaolo, Valeria (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-01-22)
      Background - Human polyomavirus 6 (HPyV6) and HPyV7 are two of the novel polyomaviruses that were originally detected in non-diseased skin. Serological studies have shown that these viruses are ubiquitous in the healthy adult population with seroprevalence up to 88% for HPyV6 and 72% for HPyV7. Both viruses are associated with pruritic skin eruption in immunocompromised patients, but a role with ...

    • Hsa-miR-323a-3p functions as a tumor suppressor and targets STAT3 in neuroblastoma cells 

      Bhavsar, Swapnil; Olsen, Lotte; Løkke, Cecilie; Koster, Jan; Flægstad, Trond; Einvik, Christer (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-03-24)
      Background: Studies conducted in the last decades have revealed a role for the non-coding microRNAs (miRNAs) in cancer development and progression. Several miRNAs within the chromosome region 14q32, a region commonly deleted in cancers, are associated with poor clinical outcome in the childhood cancer neuroblastoma. We have previously identified miR-323a-3p from this region to be downregulated in ...

    • Hsa-miR-376c-3p targets cyclin D1 and induces G1-cell cycle arrest in neuroblastoma cells 

      Bhavsar, Swapnil Parashram; Løkke, Cecilie; Flægstad, Trond; Einvik, Christer (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-09-11)
      High‑risk neuroblastoma is the most aggressive form of cancer in children. The estimated survival of children with high‑risk neuroblastoma is 40‑50% compared with low and intermediate risk neuroblastoma, which is >98 and 90‑95%, respectively. In addition, patients with high‑risk neuroblastoma often experience relapse following intensive treatments with standard chemotherapeutic drugs. Therefore ...

    • A human adipose tissue cell-type transcriptome atlas 

      Norreen-Thorsen, Marthe; Struck, Eike Christopher; Öling, Sofia Maria; Zwahlen, Martin; Von Feilitzen, Kalle; Odeberg, Jacob; Lindskog, Cecilia; Pontén, Fredrik; Uhlén, Mathias; Dusart, Philip James; Butler, Lynn (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-07-12)
      The importance of defining cell-type-specific genes is well acknowledged. Technological advances facilitate high-resolution sequencing of single cells, but practical challenges remain. Adipose tissue is composed primarily of adipocytes, large buoyant cells requiring extensive, artefact-generating processing for separation and analysis. Thus, adipocyte data are frequently absent from single-cell ...

    • Human articular chondrocytes express functional Leukotriene B4 receptors 

      Hansen, Ann Kristin; Indrevik, Jill-Tove; Figenschau, Yngve Anton; Martinez, Inigo Zubiavrre; Sveinbjørnsson, Baldur (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-02-09)
      Leukotriene B<sub>4</sub> (LTB<sub>4</sub>) is a potent chemoattractant associated with the development of osteoarthritis (OA), while its receptors BLT1 and BLT2 have been found in synovium and subchondral bone. In this study, we have investigated whether these receptors are also expressed by human cartilage cells and their potential effects on cartilage cells. The expression of LTB<sub>4</sub> ...

    • Human blood serum proteome changes after 6 hours of sleep deprivation at night 

      Bjørkum, Alvhild Alette; Duran, Ana Carasco; Roy, Dola Sinha; Rosendahl, Karen; Birkeland, Even; Stuhr, Linda Elin Birkhaug (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-09-25)
      Background: The aim of this study was to discover significantly changed proteins in human blood serum after loss of 6 h sleep at night. Furthermore, to reveal affected biological process- and molecular function categories that might be clinically relevant, by exploring systems biological databases.<p> <p>Methods: Eight females were recruited by volunteer request. Peripheral venous whole blood was ...

    • Human endogenous retrovirus W Activity in cartilage of osteoarthritis patients 

      Bendiksen, Signy; Martinez, Inigo Zubiavrre; Tümmler, Conny; Knutsen, Gunnar; Elvenes, Jan; Olsen, Elisabeth; Olsen, Randi; Moens, Ugo (Journal article; Tidsskriftartikkel; Peer reviewed, 2014)

    • Hva styrker verdigheten til kreftsyke kvinner som ønsker å dø hjemme? 

      Staats, Katrine; Tranvåg, Oscar; Grov, Ellen Karine (Journal article; Tidsskriftartikkel, 2019-05-15)
      Når pasienter ønsker å dø hjemme er det viktig at hjemmesykepleiere har god kompetanse i bruken av symptomlindrende legemidler. Hensikten med studien er å utvikle ny kunnskap om hjemmesykepleieres erfaringer med å bruke medikamentskrin i symptomlindrende omsorg for hjemmeboende pasienter i terminalfase. Vi presenterer faktorer som skaper trygghet og fremmer bruken av medikamentskrinet, i tillegg til ...

    • Hvordan forbedre? 

      Joakimsen, Peder (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-06-13)
      Hei, det er vanskelig ut fra innlegget å se hva som faktisk skal kunne bidra til en «bredere rekrutteringsbase»

    • Hyperglycemia, Assessed by HbA1c, and Future Risk of Venous Thromboembolism - The Tromsø Study 

      Lerstad, Gunhild; Brodin, Ellen Elisabeth; Enga, Kristin; Jorde, Rolf; Schirmer, Henrik; Njølstad, Inger; Svartberg, Johan; Brækkan, Sigrid Kufaas; Hansen, John-Bjarne (Journal article; Tidsskriftartikkel; Peer reviewed, 2014-03-05)
      Background: Glycated hemoglobin (HbA1c), a marker of average plasma glucose during the last 8-12 weeks, is associated with future risk of cardiovascular disease (CVD) and all-cause mortality. Objectives: To examine the association between hyperglycemia, assessed by HbA1c, and future risk of VTE in a population based cohort. Methods: HbA1c was measured in 16 156 unique subjects (25-87 years) ...

    • Hypo-osmotic stress induces the epithelial alarmin IL-33 in the colonic barrier of ulcerative colitis 

      Gundersen, Mona Dixon; Larsen, Kenneth Bowitz; Johnsen, Kay-Martin; Goll, Rasmus; Florholmen, Jon; Haraldsen, Guttorm (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-07-07)
      Epithelial alarmins are gaining interest as therapeutic targets for chronic infammation. The nuclear alarmin interleukin-33 (IL-33) is upregulated in the colonic mucosa of acute ulcerative colitis (UC) and may represent an early instigator of the infammatory cascade. However, it is not clear what signals drive the expression of IL-33 in the colonic mucosa, nor is the exact role of IL-33 elucidated. We ...

    • Hypocomplementemia as a Risk Factor for Organ Damage Accrual in Patients with Systemic Lupus Erythematosus 

      Raymond, Warren David; Eilertsen, Gro Østli; Nossent, Johannes (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-12-30)
      While it is a common practice to monitor complement levels in patients with systemic lupus erythematosus to aid in flare prediction and detection, it is unclear if this strategy is helpful in preventing subsequent organ damage. We studied longitudinal complement levels in 102 SLE patients during a median follow-up of 13.8 years (IQR 7.0, 23.1). Low complement was defined as C3 < 0.84 g/L and/or ...

    • Hypothermia and cardiac electrophysiology: a systematic review of clinical and experimental data 

      Dietrichs, Erik Sveberg; Tveita, Torkjel; Smith, Godfrey L (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-12-13)
      Moderate therapeutic hypothermia procedures are used in post-cardiac arrest care, while in surgical procedures, lower core temperatures are often utilized to provide cerebral protection. Involuntary reduction of core body temperature takes place in accidental hypothermia and ventricular arrhythmias are recognized as a principal cause for a high mortality rate in these patients. We assessed both ...