Viser treff 192-211 av 1796

    • Cabin temperature during prehospital patient transport – a prospective observational study 

      Svendsen, Tuva; Lund-Kordahl, Inger; Fredriksen, Knut (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-07-13)
      <i>Background</i> - Few studies have investigated the patient compartment temperatures during ambulance missions or its relation to admission hypothermia. Still hypothermia is a known risk factor for increased mortality and morbidity in both trauma and disease. This has special relevance to our sub-arctic region’s pre-hospital services, and we prospectively studied the environmental temperature in ...
    • Caesarean section rates and activity-based funding in Northern Norway: A model-based study using the World Health Organization's recommendation 

      Norum, Jan; Svee, Tove Elisabeth (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-07-16)
      <i>Objective</i>: Caesarean section (CS) rates vary significantly worldwide. ,e World Health Organization (WHO) has recommended a maximum CS rate of 15%. Norwegian hospitals are paid per CS (activity-based funding), employing the diagnosis-related group (DRG) system. We aimed to document how financial incentives can be affected by reduced CS rates, according to the WHO’s recommendation. <p> <p> ...
    • Caffeine and primary (migraine) headaches-friend or foe? 

      Alstadhaug, Karl Bjørnar; Andreou, Anna P. (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-12-03)
      <i>Background</i>: The actions of caffeine as an antagonist of adenosine receptors have been extensively studied, and there is no doubt that both daily and sporadic dietary consumption of caffeine has substantial biological effects on the nervous system. Caffeine influences headaches, the migraine syndrome in particular, but how is unclear.<p> <p><i>Materials and Methods</i>: This is a narrative ...
    • Calculating the 30-day survival in acute myocardial infarction: should we use the treatment chain or the hospital catchment model? 

      Norum, Jan; Hansen, Tonya Moen; Hovland, Anders; Balteskard, Lise; Haug, Bjørn; Olsen, Frank; Trovik, Thor (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-01-12)
      <p><i>Introduction</i> Acute myocardial infarction (AMI) is a potentially deadly disease and significant efforts have been concentrated on improving hospital performance. A 30-day survival rate has become a key quality of care indicator. In Northern Norway, some patients undergoing AMI are directly transferred to the Regional Cardiac Intervention Center at the University Hospital of North Norway ...
    • Can Auditory Brainstem Response be Used as a Diagnostic Tool for Patients Suffering from Schizophrenia, Attention Deficit Hyperactivity Disorder, and Bipolar Disorder? 

      Wahlström, Viktor; Åhlander, Fredrik; Wynn, Rolf (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-02-12)
      <p>Background: Psychiatric disorders, such as schizophrenia, attention deficit hyperactivity disorder (ADHD), and bipolar disorder, may sometimes be difficult to diagnose. There is a great need for a valid and reliable diagnostic tool to aid clinicians in arriving at the diagnoses in a timely and accurate manner. Prior studies have suggested that patients suffering from schizophrenia and ADHD may ...
    • Can current prognostic scores reliably guide treatment decisions in patients with brain metastases from malignant melanoma? 

      Nieder, Carsten; Marienhagen, Kirsten; Geinitz, Hans; Grosu, Anca L. (Journal article; Tidsskriftartikkel; Peer reviewed, 2011)
      We evaluated the performance of the new 4-tiered melanoma-specific graded prognostic assessment (GPA) score and the previously published general GPA score in patients with brain metastases from malignant melanoma managed with different approaches including best supportive care. Materials and Methods: Retrospective analysis of 51 patients. Compared with the original analysis of the melanoma-specific ...
    • Can video mobile phones improve CPR quality when used for dispatcher assistance during simulated cardiac arrest? 

      Bolle, Stein Roald; Gilbert, Mads; Scholl, Jeremiah (Journal article; Tidsskriftartikkel; Peer reviewed, 2009)
      Background: Because mobile telephones may support video calls, emergency medical dispatchers may now connect visually with bystanders during pre-hospital cardiopulmonary resuscitation (CPR). We studied the quality of simulated dispatcher-assisted CPR when guidance was delivered to rescuers by video calls or audio calls from mobile phones. Methods: One hundred and eighty high school students were ...
    • Can vitamin D-3 supplementation prevent bone loss in persons with MS? A placebo-controlled trial 

      Steffensen, Linn Hofsøy; Jørgensen, Lone; Straume, Bjørn; Mellgren, Svein Ivar; Kampman, Margitta Theodora (Journal article; Tidsskriftartikkel; Peer reviewed, 2011)
      Multiple sclerosis (MS) is a possible cause of secondary osteoporosis. In this phase II trial we assessed whether a weekly dose of 20,000 IU vitamin D3 prevents bone loss in ambulatory persons with MS age 18–50 years. ClinicalTrials.gov ID NCT00785473. All patients managed at the University Hospital of North Norway who fulfilled the main inclusion criteria were invited to participate in this ...
    • Cancer associated fibroblasts in stage I-IIIA NSCLC: Prognostic impact and their correlations with tumor molecular markers 

      Kilvær, Thomas Karsten; Rakaeekhanehkenari, Mehrdad; Hellevik, Turid; Al-Saad, Samer; Paulsen, Erna-Elise; Busund, Lill-Tove; Dønnem, Tom; Martinez, Inigo Zubiavrre (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-08-07)
      Background Cancer Associated Fibroblasts (CAFs) are thought to regulate tumor growth and metastasis. Fibroblast Activating Protein 1 (FAP-1) is a marker for fibroblast activation and by many recognized as the main marker of CAFs. Alpha Smooth Muscle Actin (α-SMA) is a general myofibroblast marker, and can be used to identify CAFs. This study investigates the prognostic impact of FAP-1 and α-SMA ...
    • Cancer survivors' experiences of humour while navigating through challenging landscapes - a socio-narrative approach 

      Roaldsen, Bente Lisbet; Sørlie, Tore; Lorem, Geir F (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-03-10)
      Aim: Humour is seen as a health-promoting coping strategy when dealing with life stress. The aim is to elucidate how adult cancer survivors experience and evaluate the significance of humour in daily life, from diagnosis through their entire illness trajectory, and to gain a broader understanding of humour as part of stress-coping processes during the experience of cancer as a life-threatening ...
    • Cancer-associated fibroblasts from human NSCLC survive ablative doses of radiation but their invasive capacity is reduced 

      Hellevik, Turid; Pettersen, ingvild; Berg, Vivian; Winberg, Jan-Olof; Moe, Bjørn Torvald Greve; Bartnes, Kristian; Paulssen, Ruth H; Busund, Lill-Tove; Bremnes, Roy M.; Chalmers, Antony; Martinez, Inigo Zubiavrre (Journal article; Tidsskriftartikkel; Peer reviewed, 2012)
      BACKGROUND: Cancer-Associated Fibroblasts (CAFs) are significant components of solid malignancies and play central roles in cancer sustainability, invasion and metastasis. In this study we have investigated the invasive capacity and matrix remodelling properties of human lung CAFs after exposure to ablative doses of ionizing radiation (AIR), equivalent to single fractions delivered by stereotactic ...
    • Cancer-associated fibroblasts from lung tumors maintain their immunosuppressive abilities after high-dose irradiation 

      Gorchs, Laia; Hellevik, Turid; Bruun, Jack-Ansgar; Camilio, Ketil Andre; Al-Saad, Samer; Stuge, Tor Brynjar; Martinez, Inigo Zubiavrre (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-05-12)
      Accumulating evidence supports the notion that high-dose (>5 Gy) radiotherapy (RT) regimens are triggering stronger pro-immunogenic effects than standard low-dose (2 Gy) regimens. However, the effects of RT on certain immunoregulatory elements in tumors remain unexplored. In this study, we have investigated the effects of high-dose radiotherapy (HD-RT) on the immunomodulating functions of cancer-associated ...
    • Cancer-associated fibroblasts in radiotherapy: Bystanders or protagonists? 

      Martinez, Inigo Zubiavrre; Hellevik, Turid (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-05-11)
      Background - The primary goal of radiotherapy (RT) is to induce cellular damage on malignant cells; however, it is becoming increasingly recognized the important role played by the tumor microenvironment (TME) in therapy outcomes. Therapeutic irradiation of tumor lesions provokes profound cellular and biological reconfigurations within the TME that ultimately may influence the fate of the ...
    • Cannabis Use during Pregnancy and Risk of Adverse Birth Outcomes: A Longitudinal Cohort Study 

      Gabrhelik, Roman; Mahic, Milada; Lund, Ingunn Olea; Bramness, Jørgen Gustav; Selmer, Randi Marie; Skovlund, Eva; Handal, Marte; Skurtveit, Svetlana (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-10-09)
      <i>Background</i>: With recent changes in legislation regulating recreational and medical cannabis use around the globe, increased use in pregnancy is to be expected.<p> <p><i>Objectives</i>: To investigate the association between cannabis use during pregnancy and birth outcomes. <p> <p><i>Method</i>: Data from the Norwegian Mother and Child Cohort Study (MoBa), a prospective pregnancy cohort, ...
    • Cannabis use in early adulthood is prospectively associated with prescriptions of antipsychotics, mood stabilizers, and antidepressants 

      Rognli, Eline Borger; Bramness, Jørgen Gustav; von Soest, Tilmann (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-09-27)
      <i>Objective</i> - Cannabis is an acknowledged risk factor for some mental disorders, but for others the evidence is inconclusive. Prescribed medicinal drugs can be used as proxies for mental disorders. In this study, we investigate how use of cannabis is prospectively related to prescription of antipsychotics, mood stabilizers, antidepressants, and anxiolytics.<p> <p><i>Methods</i> - Data on ...
    • Carbon Dioxide Laser Treatment Using Methylene Blue–Assisted Sinus Tract Identification in Hidradenitis Suppurativa 

      Grimstad, Øystein; Ingvarsson, Gisli (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-11)
      Keratinocytes and remnant of keratinocytes in nodules, abscesses, and sinus tracts are radically removed in surgical treatment of hidradenitis suppurativa.1 We are now using methylene blue in carbon dioxide laser surgery for patients with moderate to severe hidradenitis lesions (Hurley stage II-III). Methylene blue stains active inflammatory nodules and sinus tracts. We use a modified methylene blue ...
    • The cardiac impact of cisplatin-based chemotherapy in survivors of testicular cancer: A 30-year follow-up 

      Bjerring, Anders W.; Fosså, Sophie Dorothea; Haugnes, Hege Sagstuen; Nome, Ragnhild Veline; Stokke, Thomas Muri; Haugaa, Kristina; Kiserud, Cecilie E.; Edvardsen, Thor; Sarvari, Sebastian (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-11-05)
      Aims - Cisplatin-based chemotherapy (CBCT) is essential in the treatment of metastatic testicular cancer (TC) but has been associated with long-term risk of cardiovascular morbidity and mortality. Furthermore, cisplatin can be detected in the body decades after treatment. We aimed to evaluate the long-term impact of CBCT on cardiac function and morphology in TC survivors 30 years after treatment.< ...
    • Cardiorespiratory fitness and future risk of venous thromboembolism 

      Evensen, Line Holtet; Isaksen, Trond; Brækkan, Sigrid Kufaas; Hansen, John-Bjarne (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-08-25)
      <i>Background</i> - Cardiorespiratory fitness (CRF) is a strong predictor of future arterial cardiovascular disease and premature mortality. However, there are limited data on the association between CRF and the risk of incident venous thromboembolism (VTE).<p><p> <i>Objectives</i> - To investigate whether estimated CRF (eCRF) was associated with the risk of incident VTE in a cohort recruited ...
    • Cardiovascular Effects of Epinephrine During Experimental Hypothermia (32°C) With Spontaneous Circulation in an Intact Porcine Model 

      Mohyuddin, Rizwan; Dietrichs, Erik Sveberg; Sundaram, Predip; Kondratiev, Timofei V.; Figenschou, Marie Fjellanger; Sieck, Gary C.; Tveita, Torkjel (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-09-06)
      <i>Aims</i>: Rewarming from accidental hypothermia and therapeutic temperature management could be complicated by cardiac dysfunction. Although pharmacologic support is often applied when rewarming these patients, updated treatment recommendations are lacking. There is an underlying deficiency of clinical and experimental data to support such interventions and this prevents the development of clinical ...
    • Carers’ experiences with overnight respite care : a qualitative study 

      Gilje, Fredricka; Fjelltun, Aud-Mari Sohini; Henriksen, Nils; Norberg, Astrid; Normann, Hans Ketil (Journal article; Tidsskriftartikkel; Peer reviewed, 2009)
      Aim: The aim of this study was to explore experiences with overnight respite care (ORC) of Norwegian carers who provided care to frail elderly awaiting nursing home placement. <br> Background: In many Western countries respite care has become part of health care service provision, and various types of respite care are available. The intent with respite care can be twofold; caring for the care ...