• BAFF expression is increased in Lupus Nephritis and associated with activation of C1 inhibitor, α-1-acid-glycoprotein and endothelial markers. 

      Eilertsen, Gro Østli; Ghelue, Marijke van; Nossent, Johannes C (Journal article; Tidsskriftartikkel; Peer reviewed, 2012)
      B cell activating factor (BAFF) inhibitor therapy has recently been approved for non-renal Systemic Lupus Erythematosus (SLE). While BAFF plays a role in experimental lupus nephritis (LN), its role human LN is not well studied. Case control study in 102 SLE patients, 30 with LN (+LN) and 72 without LN (-LN) and 31 healthy controls. We analysed BAFF mRNA expression in PBMCs (BAFF-RQ) and serum BAFF ...
    • Bariatric surgery reduces fasting total fatty acids and increases n-3 polyunsaturated fatty acids in morbidly obese individuals 

      Hovland, Anders; Nestvold, Torunn Kristin; Bohov, Pavol; Trøseid, Marius; Aukrust, Pål; Berge, Rolf Kristian; Nielsen, Erik Waage; Retterstøl, Kjetil; Lappegård, Knut Tore (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-10-25)
      Background: <br> Obesity is a global pandemic leading to increased mortality and increased risk of cardiovascular disease. Bariatric surgery is an established treatment of obesity leading to weight loss and reduction of mortality. To further elucidate how bariatric surgery improves metabolic control, we explored the fatty acid (FA) profiles in morbidly obese subjects treated with lifestyle ...
    • Beta cell function after weight loss : a clinical trial comparing gastric bypass surgery and intensive lifestyle intervention 

      Hofsø, Dag; Jenssen, Trond Geir; Bollerslev, Jens; Ueland, Thor; Godang, Kristin; Stumvoll, Michael; Sandbu, Rune; Røislien, Jo; Hjelmesæth, Jøran (Journal article; Tidsskriftartikkel; Peer reviewed, 2011)
      The effects of various weight loss strategies on pancreatic beta cell function remain unclear. We aimed to compare the effect of intensive lifestyle intervention (ILI) and Roux-en-Y gastric bypass surgery (RYGB) on beta cell function. Design One year controlled clinical trial (ClinicalTrials.gov identifier NCT00273104). One hundred and nineteen morbidly obese participants without known diabetes from ...
    • Between health care and social security : psychiatric patients and the disability pension system in Norway and Russia 

      Schönfelder, Walter; Rezvyy, Grigory; Midré, Georges; Øiesvold, Terje; Olstad, Reidun (Journal article; Tidsskriftartikkel; Peer reviewed, 2007-08-16)
      Background: The official statistics of persons with mental disorders who are granted disability pension (DP) in Russia and Norway indicate large differences between the countries. Methods: This qualitative explorative hypothesis-generating study is based on text analysis of the laws, regulations and guidelines, and qualitative interviews of informants representing all the organisational elements ...
    • Blood pressure and age-related GFR decline in the general population 

      Eriksen, Bjørn Odvar; Stefansson, Vidar Tor Nyborg; Jenssen, Trond Geir; Mathisen, Ulla Dorte; Schei, Jørgen; Solbu, Marit Dahl; Wilsgaard, Tom; Melsom, Toralf (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-02-28)
      Background: <br> Hypertension is one of the most important causes of end-stage renal disease, but it is unclear whether elevated blood pressure (BP) also accelerates the gradual decline in the glomerular filtration rate (GFR) seen in the general population with increasing age. The reason may be that most studies have considered only baseline BP and not the effects of changes in BP, antihypertensive ...
    • Blood pressure target achievement and antihypertensive medication use in women and men after first-ever myocardial infarction: the Tromsø Study 1994-2016 

      Hopstock, Laila Arnesdatter; Eggen, Anne Elise; Løchen, Maja-Lisa; Mathiesen, Ellisiv B.; Nilsen, Amalie; Njølstad, Inger; Wilsgaard, Tom (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-01-03)
      Background: <br> Recurrent cardiovascular events after myocardial infarction (MI) are frequent, and gender differences in blood pressure treatment have been reported. Despite increased focus on secondary prevention, recent reports indicate that treatment targets are not achieved. There is a need for gender-specific analyses of post-MI blood pressure treatment target achievement and ...
    • Bradykinin-Induced Shock Increase Exhaled Nitric Oxide, Complement Activation and Cytokine Production in Pigs 

      Seip, Knut Fredrik; Evjenth, Bjørg; Hovland, Anders; Dybwik, Knut Gustav; Johansen, Harald Thidemann; Fure, Hilde; Mollnes, Tom Eirik; Nielsen, Erik Waage (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-03-04)
      Bradykinin is an important mediator in blood pressure regulation, ischemic precondition and capillary leakage, allergy, anaphylaxis, inflammation, and nociception, at least partly via the generation of nitric oxide (NO). Macrophages are particularly abundant in the porcine lung circulation. Upon bradykinin binding macrophages release cytokines and endothelial ...
    • Brain Damage Treated with Non Proven Intensive Training 2003-2011: A Norwegian Cost Analysis 

      Norum, Jan; Tjeldnes, Knut; Ramsvik, Arnborg (Journal article; Tidsskriftartikkel, 2012)
      There has been an increased request for intensive training and rehabilitation of patients with brain damage in Norway. These programs are demanding with regard to personnel, travelling, time and economic resources. We aimed to indicate cost and gain to make these programs cost-effective. A retrospective study included all patients referred to the Northern Norway Regional Health Authority (NNRHA) ...
    • Brain Metastases Research 1990-2010: Pattern of Citation and Systematic Review of Highly Cited Articles 

      Nieder, Carsten; Grosu, Anca L.; Mehta, Minesh P. (Journal article; Tidsskriftartikkel; Peer reviewed, 2012)
      High and continuously increasing research activity related to different aspects of prevention, prediction, diagnosis and treatment of brain metastases has been performed between 1990 and 2010. One of the major databases contains 2695 scientific articles that were published during this time period. Different measures of impact, visibility, and quality of published research are available, each with ...
    • Bronchial airway gene expression in smokers with lung or head and neck cancer 

      Van Dyck, Eric; Nazarov, Petr; Muller, Arnaud; Nicot, Nathalie; Bosseler, Manon; Pierson, Sandrine; Van Moer, Kris; Palissot, Valèrie; Mascaux, Cèline; Knolle, Ulrich; Ninane, Vincent; Nati, Romain; Bremnes, Roy M.; Vallar, Laurent; Guy, Berchem; Schlesser, Marc (Journal article; Tidsskriftartikkel; Peer reviewed, 2014)
    • The butterfly design as an alternative to the "double-A" bilateral flaps for the treatment of sacral defects 

      Weum, Sven Magne; De Weerd, Louis (Journal article; Tidsskriftartikkel; Peer reviewed, 2008-04)
      Letter to the Editor
    • Bypassing adverse injection reactions to nanoparticles through shape modification and attachment to erythrocytes 

      Wibroe, Peter Popp; Anselmo, Aaron C; Nilsson, Per; Sarode, Apoorva; Gupta, Vivek; Urbanics, Rudolf; Szebeni, Janos; Hunter, Alan Christy; Mitragotri, Samir; Mollnes, Tom Eirik; Moghimi, Seyed Moein (Journal article; Tidsskriftartikkel; Peer reviewed; Preprint, 2017-04-10)
      Intravenously injected nanopharmaceuticals, including PEGylated nanoparticles, induce adverse cardiopulmonary reactions in sensitive human subjects, and these reactions are highly reproducible in pigs. Although the underlying mechanisms are poorly understood, roles for both the complement system and reactive macrophages have been implicated. Here, we show the dominance and importance of robust ...
    • Bystander first aid in trauma – prevalence and quality: a prospective observational study 

      Bakke, Håkon Kvåle; Steinvik, Tine; Eidissen, Silje-Iren; Gilbert, Mads; Wisborg, Torben (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-06-19)
      Background: Bystander first aid and basic life support can likely improve victim survival in trauma. In contrast to bystander first aid and out-of-hospital cardiac arrest, little is known about the role of bystanders in trauma response. Our aim was to determine how frequently first aid is given to trauma victims by bystanders, the quality of this aid, the professional background of first-aid ...
    • Calculating the 30-day survival in acute myocardial infarction: should we use the treatment chain or the hospital catchment model? 

      Norum, Jan; Hansen, Tonya Moen; Hovland, Anders; Balteskard, Lise; Haug, Bjørn; Olsen, Frank; Trovik, Thor (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-01-12)
      <p><i>Introduction</i> Acute myocardial infarction (AMI) is a potentially deadly disease and significant efforts have been concentrated on improving hospital performance. A 30-day survival rate has become a key quality of care indicator. In Northern Norway, some patients undergoing AMI are directly transferred to the Regional Cardiac Intervention Center at the University Hospital of North Norway ...
    • Can Auditory Brainstem Response be Used as a Diagnostic Tool for Patients Suffering from Schizophrenia, Attention Deficit Hyperactivity Disorder, and Bipolar Disorder? 

      Wahlström, Viktor; Åhlander, Fredrik; Wynn, Rolf (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-02-12)
      <p>Background: Psychiatric disorders, such as schizophrenia, attention deficit hyperactivity disorder (ADHD), and bipolar disorder, may sometimes be difficult to diagnose. There is a great need for a valid and reliable diagnostic tool to aid clinicians in arriving at the diagnoses in a timely and accurate manner. Prior studies have suggested that patients suffering from schizophrenia and ADHD may ...
    • Can current prognostic scores reliably guide treatment decisions in patients with brain metastases from malignant melanoma? 

      Nieder, Carsten; Marienhagen, Kirsten; Geinitz, Hans; Grosu, Anca L. (Journal article; Tidsskriftartikkel; Peer reviewed, 2011)
      We evaluated the performance of the new 4-tiered melanoma-specific graded prognostic assessment (GPA) score and the previously published general GPA score in patients with brain metastases from malignant melanoma managed with different approaches including best supportive care. Materials and Methods: Retrospective analysis of 51 patients. Compared with the original analysis of the melanoma-specific ...
    • Can video mobile phones improve CPR quality when used for dispatcher assistance during simulated cardiac arrest? 

      Bolle, Stein Roald; Gilbert, Mads; Scholl, Jeremiah (Journal article; Tidsskriftartikkel; Peer reviewed, 2009)
      Background: Because mobile telephones may support video calls, emergency medical dispatchers may now connect visually with bystanders during pre-hospital cardiopulmonary resuscitation (CPR). We studied the quality of simulated dispatcher-assisted CPR when guidance was delivered to rescuers by video calls or audio calls from mobile phones. Methods: One hundred and eighty high school students were ...
    • Can vitamin D-3 supplementation prevent bone loss in persons with MS? A placebo-controlled trial 

      Steffensen, Linn Hofsøy; Jørgensen, Lone; Straume, Bjørn; Mellgren, Svein Ivar; Kampman, Margitta Theodora (Journal article; Tidsskriftartikkel; Peer reviewed, 2011)
      Multiple sclerosis (MS) is a possible cause of secondary osteoporosis. In this phase II trial we assessed whether a weekly dose of 20,000 IU vitamin D3 prevents bone loss in ambulatory persons with MS age 18–50 years. ClinicalTrials.gov ID NCT00785473. All patients managed at the University Hospital of North Norway who fulfilled the main inclusion criteria were invited to participate in this ...
    • Cancer associated fibroblasts in stage I-IIIA NSCLC: Prognostic impact and their correlations with tumor molecular markers 

      Kilvær, Thomas Karsten; Rakaeekhanehkenari, Mehrdad; Hellevik, Turid; Al-Saad, Samer; Paulsen, Erna-Elise; Busund, Lill-Tove; Dønnem, Tom; Martinez, Inigo Zubiavrre (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-08-07)
      Background Cancer Associated Fibroblasts (CAFs) are thought to regulate tumor growth and metastasis. Fibroblast Activating Protein 1 (FAP-1) is a marker for fibroblast activation and by many recognized as the main marker of CAFs. Alpha Smooth Muscle Actin (α-SMA) is a general myofibroblast marker, and can be used to identify CAFs. This study investigates the prognostic impact of FAP-1 and α-SMA ...
    • Cancer-associated fibroblasts from human NSCLC survive ablative doses of radiation but their invasive capacity is reduced 

      Hellevik, Turid; Pettersen, ingvild; Berg, Vivian; Winberg, Jan-Olof; Moe, Bjørn Torvald Greve; Bartnes, Kristian; Paulssen, Ruth H; Busund, Lill-Tove; Bremnes, Roy M.; Chalmers, Antony; Martinez, Inigo Zubiavrre (Journal article; Tidsskriftartikkel; Peer reviewed, 2012)
      BACKGROUND: Cancer-Associated Fibroblasts (CAFs) are significant components of solid malignancies and play central roles in cancer sustainability, invasion and metastasis. In this study we have investigated the invasive capacity and matrix remodelling properties of human lung CAFs after exposure to ablative doses of ionizing radiation (AIR), equivalent to single fractions delivered by stereotactic ...