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Antiviral Responses and Biological Concequences of Piscine orthoreovirus Infection in Salmonid Erythrocytes
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-01-16)
Salmonid red blood cells are the main target cells for <i>Piscine orthoreovirus</i> (PRV). Three genotypes of PRV (PRV-1,2,3) infect Atlantic salmon (<i>Salmo salar</i>), Chinook salmon (<i>Onchorhynchus tshawytscha</i>), Coho salmon (<i>Oncorhynchus kisutch</i>), rainbow trout (<i>Onchorhynchus mykiss</i>) and brown trout (<i>Salmo trutta</i>), and can cause diseases like heart and skeletal muscle ...
Antiviral defense in salmonids – Mission made possible?
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-01-30)
Viral diseases represent one of the major threats for salmonid aquaculture. Survival from viral infections are highly dependent on host innate antiviral immune defense, where interferons are of crucial importance. Neutralizing antibodies and T cell effector mechanisms mediate long-term antiviral protection. Despite an immune cell repertoire comparable to higher vertebrates, farmed fish often fail ...