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Breathtaking brains Intrinsic neural adaptations to hypoxia
(Doctoral thesis; Doktorgradsavhandling, 2016-04-07)
To maintain and restore the membrane potential that is crucial for normal function of neurons, the brain requires a constant and high energy supply. This supply is mainly covered by oxidative metabolism. When oxygen supply is impaired on a cellular level (hypoxia), such as in the case of stroke, neural energy levels become inadequate to maintain ion balance, leading to excessive ion flux and ultimately ...