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Efflux of neurotransmitter from brain slices during O2 deprivation – comparing diving and non-diving species
(Master thesis; Mastergradsoppgave, 2014-08-15)
During hypoxic insult, neuronal tissue undergoes an excitotoxic cascade of events leading to cell death. This response involves loss of membrane potential and uncontrolled release of primarily excitatory neurotransmitters.
I propose that this fatal cascade is significantly delayed or attenuated in diving species, which are adapted to repeated exposures to hypoxic conditions as a consequence of ...