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The utility of in vitro Precision-Cut Liver Slices to investigate toxicity pathways of contaminants in polar cod (Boreogadus saida)
(Master thesis; Mastergradsoppgave, 2015-06-12)
The development of in vitro methodologies has contributed significantly in elucidating mechanisms of xenobiotic toxicity in aquatic organisms. The present study aimed to develop the in vitro methodology Precision-Cut Liver Slices (PCLS) and to investigate the effects of model compounds (WY-14,643 [WY] and benzo(a)pyrene [BaP]) and two mixtures of 2- and 3-4-ring polycyclic aromatic hydrocarbons ...