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Circulating levels and prognostic cut-offs of sST2, hs-cTnT, and NT-proBNP in women vs. men with chronic heart failure
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-05-05)
Aims To define plasma concentrations, determinants, and optimal prognostic cut-offs of soluble suppression of
tumorigenesis-2 (sST2), high-sensitivity cardiac troponin T (hs-cTnT), and N-terminal pro-B-type natriuretic peptide (NTproBNP) in women and men with chronic heart failure (HF).<p>
<p>Methods and results Individual data of patients from the Biomarkers In Heart Failure Outpatient Study ...
Breakthrough infections with the omicron and delta variants of SARS-CoV-2 result in similar re-activation of vaccine-induced immunity
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-09-08)
Background: Results showing that sera from double vaccinated individuals have minimal neutralizing activity against Omicron have been interpreted as indicating the need for a third vaccine dose for protection. However, there is little information about early immune responses to Omicron infection in double vaccinated individuals.<p>
<p>Methods: We measured inflammatory mediators, antibodies to the ...
Interleukin-6 inhibition in ST-elevation myocardial infarction: Immune cell profile in the randomised ASSAIL-MI trial
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-04-30)
Background We recently showed that interleukin (IL)-6 inhibition by tocilizumab improves myocardial salvage in
ST-elevation myocardial infarction (STEMI). However, the mechanisms for this effect are not clear.<p>
<p>Methods In this exploratory sub-study of the ASSAIL-MI trial, we examined leukocyte differential counts and their
relation to myocardial salvage and peak troponin T (TnT) in STEMI ...
Markers of cellular senescence is associated with persistent pulmonary pathology after COVID-19 infection
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-08-19)
Background: The lungs are the organ most likely to sustain serious injury from coronavirus disease 2019 (COVID-19).
However, the mechanisms for long-term complications are not clear. Patients with severe COVID-19 have shorter telomere
lengths and higher levels of cellular senescence, and we hypothesized that circulating levels of the telomere-associated
senescence markers chitotriosidase, ...
Omicron Variant Generates a Higher and More Sustained Viral Load in Nasopharynx and Saliva Than the Delta Variant of SARS-CoV-2
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-10-31)
The Omicron variant of SARS-CoV-2 spreads more easily than earlier variants, possibly as a result of a higher viral load in the upper respiratory tract and oral cavity. Hence, we investigated whether the Omicron variant generates a higher viral load than that of the Delta variant in saliva and nasopharynx. Both specimens were collected from 52 Omicron and 17 Delta cases at two time points one week ...
The Effect of Protease-Activated Receptor-1 (PAR-1) Inhibition on Endothelial-Related Biomarkers in Patients with Coronary Artery Disease
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-10-20)
Abstract
Background: Vorapaxar has been shown to reduce cardiovascular mortality in postmyocardial infarction (MI) patients. Pharmacodynamic biomarker research related to
protease-activated receptor-1 (PAR-1) inhibition with vorapaxar in humans has short follow-up (FU) duration and is mainly focused on platelets rather than endothelial cells.
Aim: This article assesses systemic changes in ...
Elevated plasma levels of plasminogen activator inhibitor-1 are associated with risk of future incident venous thromboembolism
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-03-15)
Background: Plasminogen activator inhibitor-1 (PAI-1), the main inhibitor of fibrinolysis, is frequently elevated in obesity and could potentially mediate the risk of venous
thromboembolism (VTE) in obese subjects. However, whether PAI-1 is associated
with VTE remains uncertain.<p>
<p>Objective: To investigate the association between plasma PAI-1 levels and risk of future incident VTE and whether ...
T cell and monocyte/macrophage activation markers associate with adverse outcome, but give limited prognostic value in anemic patients with heart failure: results from RED-HF
(Journal article; Tidsskriftartikkel, 2018-07-26)
<i>Background</i>: Activated leukocytes may contribute to the development and progression of heart failure (HF). We investigated the predictive value of circulating levels of stable and readily detectable markers reflecting both monocyte/macrophage and T-cell activity, on clinical outcomes in HF patients with reduced ejection fraction (HFrEF).<p>
<p><i>Methods</i>: The association between ...
Index of microvascular resistance to assess the effect of rosuvastatin on microvascular function in women with chest pain and no obstructive coronary artery disease: A double-blind randomized study
(Journal article; Tidsskriftartikkel, 2019-02-21)
<i>Introduction</i>
- Many women undergoing coronary angiography for chest pain have no or only minimal coronary artery disease (CAD). However, despite the lack of obstructive CAD, they still have an increased risk of major adverse cardiovascular events. Pleiotropic effects of statins may influence microvascular function, but if statins improve microvascular function in unselected chest pain ...
Cytokine pattern in patients with ST-elevation myocardial infarction treated with the interleukin-6 receptor antagonist tocilizumab
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-08-17)
Background - Tocilizumab improves myocardial salvage index (MSI) in patients with ST-elevation myocardial infarction (STEMI), but its mechanisms of action are unclear. Here, we explored how cytokines were affected by tocilizumab and their correlations with neutrophils, C-reactive protein (CRP), troponin T, MSI and infarct size.<p>
<p>Methods - STEMI patients were randomised to receive a single ...