Vis enkel innførsel

dc.contributor.authorTomasdottir, Margret Olafia
dc.contributor.authorSigurdsson, Johann Agust
dc.contributor.authorPetursson, Halfdan
dc.contributor.authorKirkengen, Anna Luise
dc.contributor.authorKrokstad, Steinar
dc.contributor.authorMcEwen, Bruce
dc.contributor.authorHetlevik, Irene
dc.contributor.authorGetz, Linn
dc.date.accessioned2015-09-03T12:20:34Z
dc.date.available2015-09-03T12:20:34Z
dc.date.issued2015-06-18
dc.description.abstractBackground: Multimorbidity receives increasing scientific attention. So does the detrimental health impact of adverse childhood experiences (ACE). Aetiological pathways from ACE to complex disease burdens are under investigation. In this context, the concept of allostatic overload is relevant, denoting the link between chronic detrimental stress, widespread biological perturbations and disease development. This study aimed to explore associations between self-reported childhood quality, biological perturbations and multimorbidity in adulthood. Materials and Methods: We included 37 612 participants, 30–69 years, from the Nord-Trøndelag Health Study, HUNT3 (2006–8). Twenty one chronic diseases, twelve biological parameters associated with allostatic load and four behavioural factors were analysed. Participants were categorised according to the self-reported quality of their childhood, as reflected in one question, alternatives ranging from ‘very good’ to ‘very difficult’. The association between childhood quality, behavioural patterns, allostatic load and multimorbidity was compared between groups. Results: Overall, 85.4% of participants reported a ‘good’ or ‘very good’ childhood; 10.6% average, 3.3% ‘difficult’ and 0.8% ‘very difficult’. Childhood difficulties were reported more often among women, smokers, individuals with sleep problems, less physical activity and lower education. In total, 44.8% of participants with a very good childhood had multimorbidity compared to 77.1% of those with a very difficult childhood (Odds ratio: 5.08; 95% CI: 3.63– 7.11). Prevalences of individual diseases also differed significantly according to childhood quality; all but two (cancer and hypertension) showed a significantly higher prevalence (p<0.05) as childhood was categorised as more difficult. Eight of the 12 allostatic parameters differed significantly between childhood groups.en_US
dc.description.sponsorshipThe HUNT3 Survey was mainly funded by the Norwegian Ministry of Health, the Norwegian University of Science and Technology, the Norwegian Research Council (the FUGE program), Central Norway Regional Health Authority, the Nord-Trøndelag County Council and the Norwegian Institute of Public Health. The present analysis received support from the Research Fund of the Icelandic College of Family Physicians. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.en_US
dc.identifier.citationPLoS ONE 10(6): e0130591en_US
dc.identifier.cristinIDFRIDAID 1261151
dc.identifier.doi10.1371/journal.pone.0130591
dc.identifier.issn1932-6203
dc.identifier.urihttps://hdl.handle.net/10037/8010
dc.identifier.urnURN:NBN:no-uit_munin_7596
dc.language.isoengen_US
dc.publisherPublic Library of Science (PLoS)en_US
dc.rights.accessRightsopenAccess
dc.subjectbehavioural patternsen_US
dc.subjectallostatic parametersen_US
dc.subjectadverse childhood experiences (ACE)en_US
dc.subjectVDP::Medical disciplines: 700::Basic medical, dental and veterinary science disciplines: 710en_US
dc.subjectVDP::Medisinske Fag: 700::Basale medisinske, odontologiske og veterinærmedisinske fag: 710en_US
dc.subjectmultimorbidityen_US
dc.titleSelf Reported Childhood Difficulties, Adult Multimorbidity and Allostatic Load. A Cross-Sectional Analysis of the Norwegian HUNT Studyen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


Tilhørende fil(er)

Thumbnail
Thumbnail

Denne innførselen finnes i følgende samling(er)

Vis enkel innførsel