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dc.contributor.authorJohansson, Mattias
dc.contributor.authorAnouar, Fanidi
dc.contributor.authorMuller, David C.
dc.contributor.authorBassett, Julie K.
dc.contributor.authorMidttun, Øivind
dc.contributor.authorVollset, Stein Emil
dc.contributor.authorTravis, Ruth C.
dc.contributor.authorPalli, Domenico
dc.contributor.authorMattiello, Amalia
dc.contributor.authorSieri, Sabina
dc.contributor.authorTrichopoulou, Antonia
dc.contributor.authorLagiou, Pagona
dc.contributor.authorTrichopoulos, Dimitrios
dc.contributor.authorLjungberg, Börje
dc.contributor.authorHallmans, Göran
dc.contributor.authorWeiderpass, Elisabete
dc.contributor.authorSkeie, Guri
dc.contributor.authorGonzalez, Carlos A.
dc.contributor.authorDorronsoro, Miren
dc.contributor.authorPeeters, Petra H.
dc.contributor.authorBueno-de-Mesquita, H. B(as).
dc.contributor.authorRos, Martine M.
dc.contributor.authorRuault, Marie-Christine Boutron
dc.contributor.authorFagherazzi, Guy
dc.contributor.authorClavel, Françoise
dc.contributor.authorSanchez, Maria-Jose
dc.contributor.authorGurrea, Aurelio Barricarte
dc.contributor.authorNavarro, Carmen
dc.contributor.authorQuirós, J. Ramón
dc.contributor.authorOvervad, Kim
dc.contributor.authorTjønneland, Anne
dc.contributor.authorAleksandrova, Krassimira
dc.contributor.authorVineis, Paolo
dc.contributor.authorGunter, Marc J.
dc.contributor.authorKaaks, Rudolf
dc.contributor.authorGiles, Graham
dc.contributor.authorRelton, Caroline
dc.contributor.authorRiboli, Elio
dc.contributor.authorBoeing, Heiner
dc.contributor.authorUeland, Per Magne
dc.contributor.authorSeveri, Gianluca
dc.contributor.authorBrennan, Paul
dc.date.accessioned2015-09-16T08:24:02Z
dc.date.available2015-09-16T08:24:02Z
dc.date.issued2014-11-05
dc.description.abstractThe etiology of renal cell carcinoma (RCC) is only partially understood, but a metabolic component appears likely. We investigated biomarkers of one-carbon metabolism and RCC onset and survival. Methods The European Prospective Investigation into Cancer and Nutrition (EPIC) recruited 385747 participants with blood samples between 1992 and 2000, and this analysis included 556 RCC case-control pairs. A subsequent replication study included 144 case-control pairs nested within the Melbourne Collaborative Cohort Study (MCCS). Plasma concentrations of vitamin B2, vitamin B6, folate, vitamin B12, methionine and homocysteine were measured in prediagnostic samples and evaluated with respect to RCC risk using conditional and unconditional logistic regression models, and to all-cause mortality in RCC cases using Cox regression models. All statistical tests were two-sided. Results EPIC participants with higher plasma concentrations of vitamin B6 had lower risk of RCC, the odds ratio comparing the 4th and 1st quartiles (OR4vs1) being 0.40 95% confidence interval [CI] = 0.28 to 0.57, Ptrend < .001. We found similar results after adjusting for potential confounders (adjusted Ptrend < .001). In survival analysis, the hazard ratio for all-cause mortality in RCC cases when comparing the 4th and 1st quartiles (HR4vs1) of vitamin B6 was 0.57 (95% CI = 0.37 to 0.87, Ptrend < .001). Subsequent replication of these associations within the MCCS yielded very similar results for both RCC risk (OR4vs1  =  0.47, 95% CI  =  0.23 to 0.99, Ptrend  =  .07) and all-cause mortality (HR4vs1  =  0.56, 95% CI  =  0.27 to 1.17, Ptrend = .02). No association was evident for the other measured biomarkers. Conclusion Study participants with higher circulating concentrations of vitamin B6 had lower risk of RCC and improved survival following diagnosis in two independent cohorts.en_US
dc.identifier.citationJNCI Journal of the National Cancer Institute (2014) 106 (12): dju327en_US
dc.identifier.cristinIDFRIDAID 1227923
dc.identifier.doi10.1093/jnci/dju327
dc.identifier.issn0027-8874
dc.identifier.urihttps://hdl.handle.net/10037/8077
dc.identifier.urnURN:NBN:no-uit_munin_7661
dc.language.isoengen_US
dc.publisherOxford University Pressen_US
dc.rights.accessRightsopenAccess
dc.subjectVDP::Medisinske Fag: 700::Basale medisinske, odontologiske og veterinærmedisinske fag: 710::Medisinsk immunologi: 716en_US
dc.subjectVDP::Medical disciplines: 700::Basic medical, dental and veterinary science disciplines: 710::Medical immunology: 716en_US
dc.subjectOne-Carbon Metabolismen_US
dc.subjectRenal Cell Carcinomaen_US
dc.subjectEuropean Prospective Investigation into Cancer and Nutrition (EPIC)en_US
dc.subjectvitamin B6en_US
dc.subjectkidney canceren_US
dc.subjectbiomarkersen_US
dc.titleCirculating biomarkers of one-carbon metabolism in relation to renal cell carcinoma incidence and survivalen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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