• Analysis of parameters influencing pathogen concentration in a room with displacement ventilation using computational fluid dynamics and Taguchi methods 

      Yuce, Bahadir Erman; Aganovic, Amar; Nielsen, Peter Vilhelm; Wargocki, Pawel (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-10-30)
      Analyzing multiple physical factors simultaneously to determine optimal ventilation solutions can be challenging. Furthermore, this type of analysis needs a large case number to be investigated, making the problem’s solution unfeasible. This study tackled these challenges by integrating Computational Fluid Dynamics (CFD) with the Taguchi method to overcome these issues. Our previous research ...
    • Applying the response surface methodology to predict the energy retrofit performance of the TABULA residential building stock 

      Aganovic, Amar; Kadric, Edin; Kadric, Dzana; Delalic-Gurda, Berina; Jackson, Steven (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-09-28)
      Recent advances in computing software have enabled the development of calibrated building energy simulations tools that allow retrofit-related analysis including optimization and energy-efficient building design. However, to create a national energy and climate plan, using these tools may imply a great deal of effort (time, cost, and human resources) to carry out simulations for the full set of ...
    • Comparative Evaluation of Four RANS Turbulence Models for Aerosol Dispersion from a Cough 

      Owolabi, Jibola Obafemi; Khawaja, Hassan; Aganovic, Amar (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-06-16)
      The study of aerosol dispersion in indoor environments is essential to understanding and mitigating airborne virus transmission, such as SARS-CoV-2. Computational Fluid Dynamics (CFD) has emerged as a valuable tool for investigating aerosol dispersion, providing an alternative to costly experimental methods. In this study, we investigated the performance of four (4) Reynolds-averaged Navier-Stokes ...
    • Comparing RANS with LES - AMR Study in Indoor Bio-aerosol Transmission 

      Owolabi, Jibola Obafemi; Khawaja, Hassan; Aganovic, Amar (Conference object; Konferansebidrag, 2022)
      The study presents the multiphysics modeling of bio-aerosols generated from human respiratory impulses such as coughing, sneezing, breathing, and talking. These droplet-packed viruses exploit the influence of airflow for effortless transmission, rendering them a potential health risk to individuals in the same indoor environment. To gain insight into the transmission of these airborne particles, ...
    • Cost-related analysis of implementing energy-efficient retrofit measures in the residential building sector of a middle-income country – A case study of Bosnia and Herzegovina 

      Kadrić, Džana; Aganovic, Amar; Martinović, Sandra; Delalić, Nijaz; Delalić-Gurda, Berina (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-12-15)
      This study presents an in-depth analysis of the cost structure when planning EE retrofit measures in the residential sector in Bosnia and Herzegovina. The analysis showed that implementing EE retrofit measures would result in substantial energy savings in single-family houses, however, the specific cost of implementing EE retrofit measures per resident for single-family houses is on average 2.8 ...
    • Does the exponential Wells–Riley model provide a good fit for human coronavirus and rhinovirus? A comparison of four dose–response models based on human challenge data 

      Aganovic, Amar; Kadric, Edin (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-06-15)
      The risk assessments during the COVID-19 pandemic were primarily based on dose–response models derived from the pooled datasets for infection of animals susceptible to SARS-CoV. Despite similarities, differences in susceptibility between animals and humans exist for respiratory viruses. The two most commonly used dose–response models for calculating the infection risk of respiratory viruses are the ...
    • Estimating the impact of indoor relative humidity on SARS-CoV-2 airborne transmission risk using a new modification of the Wells-Riley model 

      Aganovic, Amar; Bi, Yang; Cao, Guangyu; Drangsholt, Finn; Kurnitski, Jarek; Wargocki, Pawel (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-08-23)
      A novel modified version of the Wells-Riley model was used to estimate the impact of relative humidity (RH) on the removal of respiratory droplets containing the SARS-CoV-2 virus by deposition through gravitational settling and its inactivation by biological decay; the effect of RH on susceptibility to SARS-CoV-2 was not considered. These effects were compared with the removal achieved by increased ...
    • Experimental study on the exposure level of surgical staff to SARS-CoV-2 in operating rooms with mixing ventilation under negative pressure 

      Bi, Yang; Aganovic, Amar; Mathisen, Hans Martin; Cao, Guangyu (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-04-21)
      The purpose of this study was to reveal the exposure level of surgical staff to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) from the patient's nose and wound during operations on COVID-19 patients. The tracer gas N<sub>2</sub>O is used to simulate SARS-CoV-2 from the patient's nose and wound. In this study, concentration levels of tracer gas were measured in the breathing zones of ...
    • Experimental Study on the Surgical Microenvironment in an Operating Room with Mixing Ventilation under Positive and Negative Pressure 

      Bi, Yang; Heggebø, Frida Josefine; Harsem, Trond Thorgeir; Mathisen, Hans Martin; Aganovic, Amar; Cao, Guangyu (Chapter; Bokkapittel, 2021)
      Due to the outbreak of Covid-19, negative pressure operating room (NPOR) are strongly recommended to be applied to prevent spreading virus from infected patients to adjacent rooms during surgery procedures. However, there have been few experimental studies on the effect of OR pressure difference on the surgical microenvironment. This study aims to experimentally investigate the airflow distribution ...
    • Experimental study on the surgical microenvironment in an operating room with mixing ventilation under positive and negative pressure 

      Bi, Yang; Josefine Heggebø, Frida; Harsem, Trond Thorgeir; Mathisen, Hans Martin; Aganovic, Amar; Cao, Guangyu (Chapter; Bokkapittel, 2021)
      Due to the outbreak of Covid-19, negative pressure operating room (NPOR) are strongly recommended to be applied to prevent spreading virus from infected patients to adjacent rooms during surgery procedures. However, there have been few experimental studies on the effect of OR pressure difference on the surgical microenvironment. This study aims to experimentally investigate the airflow distribution ...
    • Investigating RANS Turbulence Models for Predicting Airflow Dispersion in Enclosed Environments: Numerical Simulation and Experimental Validation 

      Owolabi, Jibola Obafemi; Dhar, Sushmit; Muhammed, Manaf; Khawaja, Hassan Abbas; Aganovic, Amar; Virk, Muhammad Shakeel (Conference object; Konferansebidrag, 2023-12)
      The dispersion of respiratory aerosol particles in enclosed environments poses a significant challenge to understanding the transmission of airborne infectious diseases, mainly due to the influence of turbulence on the propagation of aerosol particles. Turbulence, with its complex and chaotic nature, is a prevailing phenomenon in a fluid flow. Four widely used Reynolds-Averaged Navier-Stokes (RANS) ...
    • Modeling the impact of indoor relative humidity on the infection risk of five respiratory airborne viruses 

      Aganovic, Amar; Bi, Yang; Cao, Guangyu; Kurnitski, Jarek; Wargocki, Pawel (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-07-07)
      With a modified version of the Wells-Riley model, we simulated the size distribution and dynamics of five airborne viruses (measles, influenza, SARS-CoV-2, human rhinovirus, and adenovirus) emitted from a speaking person in a typical residential setting over a relative humidity (RH) range of 20–80% and air temperature of 20–25 °C. Besides the size transformation of virus-containing droplets due to ...
    • Multi-objective optimization of energy-efficient retrofitting strategies for single-family residential homes: Minimizing energy consumption, CO2 emissions and retrofit costs 

      Kadrić, Džana; Aganovic, Amar; Kadrić, Edin (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-09-08)
      The retrofitting of buildings for improved energy efficiency has been recognized as crucial for achieving climate mitigation goals in Bosnia and Herzegovina (B&H). However, performing multi-objective optimizations for retrofitting existing buildings poses challenges, as it requires balancing conflicting objectives such as retrofit costs, energy savings, and CO<sub>2</sub> reduction. To tackle ...
    • New dose-response model and SARS-CoV-2 quanta emission rates for calculating the long-range airborne infection risk 

      Aganovic, Amar; Cao, Guangyu; Wargocki, Pawel; Kurnitski, Jarek (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-12-14)
      Predictive models for airborne infection risk have been extensively used during the pandemic, but there is yet still no consensus on a common approach, which may create misinterpretation of results among public health experts and engineers designing building ventilation. In this study we applied the latest data on viral load, aerosol droplet sizes and removal mechanisms to improve the Wells Riley ...
    • pH-dependent endocytosis mechanisms for influenza A and SARS-coronavirus 

      Aganovic, Amar (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-05-10)
      The ongoing SARS-CoV-2 pandemic and the influenza epidemics have revived the interest in understanding how these highly contagious enveloped viruses respond to alterations in the physicochemical properties of their microenvironment. By understanding the mechanisms and conditions by which viruses exploit the pH environment of the host cell during endocytosis, we can gain a better understanding ...
    • Post-COVID ventilation design: Infection risk-based target ventilation rates and point source ventilation effectiveness 

      Kurnitski, Jarek; Kiil, Martin; Mikola, Alo; Võsa, Karl-Villem; Aganovic, Amar; Schild, Peter G.; Seppänen, Olli (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-07-19)
      Ventilation, air filtration and disinfection have been found to be the main engineering measures to control the airborne respiratory infection transmission in shared indoor spaces. Wells-Riley model modifications allow to calculate the infection risk probability, but gaps in viral load data, risk control methods and dealing with incomplete mixing have resulted in ventilation recommendations falling ...
    • A systematic review of operating room ventilation 

      Sadrizadeh, Sasan; Aganovic, Amar; Bogdan, Anna; Wang, Cong; Afshari, Alireza; Hartmann, Anne; Croitoru, Cristiana; Khan, Amirul; Kriegel, Martin; Lind, Merethe; Liu, Zhijian; Melikov, Arsen; Mo, Jinhan; Rotheudt, Hansjörg; Yao, Runming; Zhang, Yixian; Abouali, Omid; Langvatn, Håkon; Sköldenberg, Olof; Cao, Guangyu (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-05-18)
      Ventilation systems are the primary way of eliminating airborne pathogenic particles in an operating room (OR). However, such systems can be complex due to factors such as different surgical instruments, diverse room sizes, various staff counts, types of clothing used, different surgical types and duration, medications, and patient conditions. OR ventilation should provide a thermally comfortable ...
    • Ventilation design conditions associated with airborne bacteria levels within the wound area during surgical procedures: a systematic review 

      Aganovic, Amar; Cao, Guangyu; Fečer, Tomáš; Ljungqvist, Bengt L.; Lytsy, Birgitta; Radtke, Andreas; Reinmüller, Berit; Traversari, Roberto A.A.L. (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-04-26)
      Without confirmation of the ventilation design conditions (typology and airflow rate), the common practice of identifying unidirectional airflow (UDAF) systems as equivalent to ultra-clean air ventilation systems may be misleading, but also any claims about the ineffectiveness of UDAF systems should be doubted. The aim of this review was to assess and compare ventilation system design conditions for ...
    • Zonal modeling of air distribution impact on the long-range airborne transmission risk of SARS-CoV-2 

      Aganovic, Amar; Cao, Guangyu; Kurnitski, Jarek; Melikov, Arsen; Wargocki, Pawel (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-08-28)
      A widely used analytical model to quantitatively assess airborne infection risk is the Wells-Riley model which is limited to complete air mixing in a single zone. However, this assumption tends not to be feasible (or reality) for many situations. This study aimed to extend the Wells-Riley model so that the infection risk can be calculated in spaces where complete mixing is not present. Some more ...