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dc.contributor.authorNaderkhani, Elenaz
dc.contributor.authorVasskog, Terje
dc.contributor.authorFlaten, Gøril Eide
dc.date.accessioned2016-02-25T14:55:09Z
dc.date.available2016-06-20T05:50:03Z
dc.date.issued2015-06-20
dc.description.abstractA prerequisite for successful oral drug therapy is the drug’s ability to cross the gastrointestinal barrier. Considering the increasing number of new chemical entities in modern drug discovery, reliable and fast in vitro models are required for early and efficient prediction of intestinal permeability. To mimic the intestinal environment, use of biorelevant media may provide valuable information on in vivo drug permeation. The present study aims at improving the novel biomimetic phospholipid vesicle-based permeation assay’s (PVPAbiomimetic) biorelevance by investigating the applicability of the biorelevant media; fasted state simulated intestinal fluid (FaSSIF) and fed state simulated intestinal fluid (FeSSIF). The FaSSIF and FeSSIF’s influence on the permeability of the model drugs acyclovir, indomethacin, griseofulvin and nadolol was then assessed. The barriers’ robustness in terms of storage stability was also evaluated. The barriers were found to maintain their integrity in presence of FaSSIF and FeSSIF. The model drugs showed changes in permeability in presence of the different simulated intestinal fluids that was in agreement with previous reports. Moreover, the barriers showed improved storage stability by maintaining its integrity for 6 months. Altogether, this study moves the PVPAbiomimetic an important step towards a better in vitro permeability model for use in drug development.en_US
dc.descriptionThis is the accepted manuscript version. Published version at <a href=http://dx.doi.org/10.1016/j.ejps.2015.03.017>http://dx.doi.org/10.1016/j.ejps.2015.03.017</a>.en_US
dc.identifier.citationEuropean Journal of Pharmaceutical Sciences 2015, 73:64-71en_US
dc.identifier.issn0928-0987
dc.identifier.otherFRIDAID 1238631
dc.identifier.other10.1016/j.ejps.2015.03.017
dc.identifier.urihttps://hdl.handle.net/10037/8566
dc.identifier.urnURN:NBN:no-uit_munin_8127
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.rights.accessRightsopenAccess
dc.subjectLiposomesen_US
dc.subjectpermeabilityen_US
dc.subjectin vitro modelen_US
dc.subjectartificial membraneen_US
dc.subjectlipiden_US
dc.subjectsimulated intestinal fluiden_US
dc.subjectVDP::Medisinske Fag: 700::Basale medisinske, odontologiske og veterinærmedisinske fag: 710::Farmakologi: 728en_US
dc.subjectVDP::Medical disciplines: 700::Basic medical, dental and veterinary science disciplines: 710::Pharmacology: 728en_US
dc.titleBiomimetic PVPA in vitro model for estimation of the intestinal drug permeability using fasted and fed state simulated intestinal fluidsen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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