Blar i forfatter Artikler, rapporter og annet (matematikk og statistikk) "Brandsdal, Bjørn Olav"

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    • Dynamic self-organisation of haematopoiesis and (a)symmetric cell division 

      Måløy, Marthe; Måløy, Frode; Jakobsen, Per; Brandsdal, Bjørn Olav (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-12-05)
      A model of haematopoiesis that links self-organisation with symmetric and asymmetric cell division is presented in this paper. It is assumed that all cell divisions are completely random events, and that the daughter cells resulting from symmetric and asymmetric stem cell divisions are, in general, phenotypically identical, and still, the haematopoietic system has the flexibility to self-renew, ...

    • Stem cell regulation: Implications when differentiated cells regulate symmetric stem cell division 

      Høyem, Marte Rørvik; Måløy, Frode; Jakobsen, Per; Brandsdal, Bjørn Olav (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-05-19)
      We use a mathematical model to show that if symmetric stem cell division is regulated by differentiated cells, then changes in the population dynamics of the differentiated cells can lead to changes in the population dynamics of the stem cells. More precisely, the relative fitness of the stem cells can be affected by modifying the death rate of the differentiated cells. This result is interesting ...