The zinc metalloprotease pseudolysin (PLN) secreted from Pseudomonas aeruginosa degrades extracellular proteins to produce bacterial nutrition, and various types of PLN inhibitors have been developed to suppress the bacterial growth. However, as the structure of the ligand-binding pocket of PLN has large similarities to those of human matrix metalloproteinases (MMPs) and other human zinc metalloprotease, ...

The arithmetic mean/geometric mean inequality (AM/GM inequality) facilitates classes of nonnegativity certificates and of relaxation techniques for polynomials and, more generally, for exponential sums. Here, we present a first systematic study of the AM/GM-based techniques in the presence of symmetries under the linear action of a finite group. We prove a symmetry-adapted representation theorem and ...

Aim/Background - The aim of this study was to evaluate the feasibility and efficacy, in terms of overall survival, of intensified upfront systemic therapy in patients with metastatic hormone-sensitive prostate cancer who lived in rural Nordland County, Norway.<p> <p>Patients and methods - Overall 117 patients were included in this retrospective study. Three cohorts were created: early docetaxel ...

The Stroop interference task is indispensable to current neuropsychological practice. Despite this, it is limited in its potential for repeated administration, its sensitivity and its demands on professionals and their clients. We evaluated a digital Stroop deployed using a smart device. Spoken responses were timed using automated speech recognition. Participants included adult nonpatients (N = ...

OBJECTIVE - To systematically identify and critically assess the quality of clinical practice guidelines for the management of SARS-CoV-2 infection in pregnancy.<p> <p>DATA SOURCES - Medline, Scopus, and ISI Web of Science databases were searched until February 15, 2022.<p> <p>STUDY ELIGIBILITY CRITERIA - Inclusion criteria were clinical practice guidelines on the management of SARS-CoV-2 ...

Background - The psychologic consequences of acute venous thromboembolism (VTE) have not been investigated in depth.<p> <p>Objectives We aimed to examine the association between VTE and the risk of subsequent depression.<p> <p>Methods - Using Danish nationwide registries, we established a population-based cohort of 64 596 individuals with incident VTE during 1996 to 2016 and a comparison ...

Airborne meteorological and aerosol measurements have been performed in Longyearbyen (Svalbard islands) in the summer of 2018, coupling an instrumental aerosol payload with a meteorological radiosonde deployed on a tethered balloon. More than 70 vertical profiles of aerosol and meteorological properties have been recorded up to a maximum altitude of 1.2 km. As a main result, the present work provides ...

A football club is exposed to a soft budget constraint (SBC) syndrome if it still survives after finding it impossible to break even financially in the long run. This in-depth case study presents a historical analysis of the evolution of an SBC syndrome in a top-tier Arctic football club over 30 years using public archive data. In oral speeches, strategy documents, and other official situations, ...

The growing installation of distributed energy resources (DERs) in a distribution network (DN) poses substantial issues related to voltage regulation. Due to constrained switching operation and slower response time, traditional voltage regulation devices cannot handle current voltage-related challenges. One alternative to solve these problems is to use smart converters to control the reactive ...

Abandoned, lost, and discarded fishing gear (ALDFG) is claimed to be a global problem with impacts on marine animals and ecosystems, posing considerable ecological and socioeconomic challenges. Nonetheless, insufficient understanding regarding how marine ecosystem services are affected by ALDFG creates a knowledge gap that challenges a holistic estimation of the long-term economic impacts of using ...