Show simple item record

dc.contributor.authorJensen, Ida-Johanne
dc.contributor.authorWalquist, Mari
dc.contributor.authorLiaset, Bjørn
dc.contributor.authorElvevoll, Edel Oddny
dc.contributor.authorEilertsen, Karl-Erik
dc.date.accessioned2017-01-31T14:34:05Z
dc.date.available2017-01-31T14:34:05Z
dc.date.issued2016-02-02
dc.description.abstract<b>Background:</b> It is now increasingly recognized that the beneficial effects of seafood consumption is not limited to lipids and fatty acid, but that the protein part, i.e., peptides and amino acids, together with vitamins and even unknown bioactive constituents also are important for disease prevention. This study was designed to evaluate the putative anti-atherogenic effects of different protein sources (a lean seafood and a nonseafood) in apolipoprotein E-deficient (apoE−/− ) mice.<br> <b>Methods:</b> Twenty-four 5-week-old female apoE−/− mice were fed Western type diets containing chicken or a combination of cod and scallops as dietary protein sources for 13 weeks. Atherosclerotic plaque burden, weight, serum levels of leptin, glucose and LDL cholesterol as well as gene expressions from liver and heart were evaluated. Statistical analyses were performed using SPSS. Differences between the variables were evaluated using independent t-test or Mann–Whitney U test for normally and non-normally distributed variables, respectively. Normality was defined by the Shapiro-Wilk test.<br> <b>Results:</b> The mice fed cod-scallop had a 24 % (p < 0.05) reduced total aorta atherosclerotic plaque burden compared to the chicken fed group, whereas the reduction in plaque in the less lesion prone thoracic and abdominal parts of the descending aorta were 46 % (p < 0.05) and 56 % (p < 0.05), respectively. In addition, mice fed cod-scallop gained less weight, and had lower serum levels of leptin, glucose and LDL cholesterol, compared to those fed chicken. Analysis of expression of the genes from liver and heart showed that hepatic endogenous antioxidant paraoxonase 2 (Pon2 gene) and the vascular cell adhesion molecule VCAM-1 (Vcam1 gene) were down regulated in mice fed cod-scallop compared to mice fed chicken.<br> <b>Conclusion:</b> The present study revealed a metabolic beneficial effect of lean seafood compared to chicken, as atherosclerotic plaque burden, serum glucose, leptin and LDL cholesterol levels were reduced in mice fed cod-scallop.en_US
dc.descriptionThis is an open access article distributed under the terms of the <a href="https://creativecommons.org/licenses/by/4.0/"> Creative Commons Attribution License</a>, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. <br> This article is also available via DOI:<a href="http://dx.doi.org/10.1186/s12986-016-0068-z">10.1186/s12986-016-0068-z</a>en_US
dc.identifier.citationJensen I, Walquist M, Liaset B, Elvevoll EO, Eilertsen KE. Dietary intake of cod and scallop reduces atherosclerotic burden in female apolipoprotein E-deficient mice fed a Western-type high fat diet for 13 weeks. Nutrition & Metabolism. 2016;13(8)en_US
dc.identifier.cristinIDFRIDAID 1331261
dc.identifier.doi10.1186/s12986-016-0068-z
dc.identifier.issn1743-7075
dc.identifier.urihttps://hdl.handle.net/10037/10271
dc.language.isoengen_US
dc.relation.journalNutrition & Metabolism
dc.rights.accessRightsopenAccessen_US
dc.subjectApolipoprotein E-deficient miceen_US
dc.subjectAtherosclerosisen_US
dc.subjectPlaque burdenen_US
dc.subjectDietary intakeen_US
dc.subjectGene expressionen_US
dc.subjectVDP::Medisinske Fag: 700::Helsefag: 800::Ernæring: 811en_US
dc.subjectVDP::Medical disciplines: 700::Health sciences: 800::Nutrition: 811en_US
dc.titleDietary intake of cod and scallop reduces atherosclerotic burden in female apolipoprotein E-deficient mice fed a Western-type high fat diet for 13 weeksen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


File(s) in this item

Thumbnail

This item appears in the following collection(s)

Show simple item record