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dc.contributor.authorOfte, Hilde Karen
dc.contributor.authorTronvik, Erling Andreas
dc.contributor.authorAlstadhaug, Karl Bjørnar
dc.date.accessioned2017-03-10T09:27:44Z
dc.date.available2017-03-10T09:27:44Z
dc.date.issued2016-02-29
dc.description.abstractBackground Cluster headache (CH) is regarded as a chronobiological disorder. The hypothalamic biological clock may thus be involved in the pathophysiology, but few studies have actually investigated this in CH patients. A variable number tandem repeat (VNTR) polymorphism of the PER3 clock gene has been associated to preferred daily rhythm (chronotype) in several studies. We aimed to study the distribution of PER3 VNTR polymorphisms and chronotypes in a CH population. Methods We used blood samples from a biobank of CH patients for genetic tests, and invited all tested patients to complete the Horne-Ostberg Morningness-eveningness Questionnaire (MEQ), the Pittsburgh sleep quality Index (PSQI) and the Shift Work Index. Genotypes were compared to a previously tested population of 432 healthy students. Results One hundred forty nine patients were genotyped, and we found no difference in PER3 VNTR polymorphisms between patients and controls. Seventy-four patients completed the MEQ (54 men, 20 women, mean age 52.3 years ± 13.4), and chronotypes were as follows: 12 % morning-, 37 % intermediate-, and 51 % evening types. Compared with a previous Danish study of CH patients and controls, there were no difference in chronotype distribution. Sixty percent of patients were defined as bad sleepers (PSQI >5), and 51 % of patients currently employed were shift workers. Conclusions No association between CH, PER3 VNTR polymorphism and chronotype was found in this study.en_US
dc.descriptionPublished version. Source at <a href=http://doi.org/10.1186/s10194-016-0611-3>http://doi.org/10.1186/s10194-016-0611-3</a>. License <a href=https://creativecommons.org/licenses/by/4.0/>CC BY 4.0</a>.en_US
dc.identifier.citationOfte HK, Tronvik E, Alstadhaug KB. Lack of association between cluster headache and PER3 clock gene polymorphism. The Journal of Headache and Pain. 2016;17(1):1-6en_US
dc.identifier.cristinIDFRIDAID 1370106
dc.identifier.doi10.1186/s10194-016-0611-3
dc.identifier.issn1129-2369
dc.identifier.issn1129-2377
dc.identifier.urihttps://hdl.handle.net/10037/10531
dc.language.isoengen_US
dc.publisherSpringeren_US
dc.relation.journalThe Journal of Headache and Pain
dc.rights.accessRightsopenAccessen_US
dc.subjectCluster headacheen_US
dc.subjectChronotypeen_US
dc.subjectPERIOD3en_US
dc.subjectClock genesen_US
dc.subjectShift worken_US
dc.subjectVDP::Medical disciplines: 700::Clinical medical disciplines: 750::Neurology: 752en_US
dc.titleLack of association between cluster headache and PER3 clock gene polymorphismen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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