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dc.contributor.authorLindgren, Lenita
dc.contributor.authorBergdahl, Jan
dc.contributor.authorNyberg, Lars
dc.date.accessioned2017-03-10T15:23:47Z
dc.date.available2017-03-10T15:23:47Z
dc.date.issued2016
dc.description.abstractHippocampal volume has been found to be smaller in individuals with stress-related disorders, but it remains unclear whether smaller volume is a consequence of stress or rather a vulnerability factor. Here, we examined this issue by relating stress levels to hippocampal volumes in healthy participants examined every 5 years in a longitudinal population-based study. Based on scores of 25- to 60-year–old participants on the perceived stress questionnaire, we defined moderately to high (n = 35) and low (n = 76) stress groups. The groupswere re-examined after 5 years (at the 6th studywave). Historical data on subjective stresswere available up to 10 years prior toWave 5. At the first MRI session, the moderately to high stress group had a significantly smaller hippocampal volume, as measured by FreeSurfer (version 5.3), compared with the low-stress group. At follow-up, group differences in stress levels and hippocampal volume remained unchanged. In retrospective analyses of subjective stress, the observed group difference in stress was found to be stable. The long-term stability of group differences in perceived stress and hippocampal volume suggests that a small hippocampal volume may be a vulnerability factor for stress-related disorders.en_US
dc.descriptionPublished version. Source at <a href=http://dx.doi.org/10.1093/cercor/bhw154> http://dx.doi.org/10.1093/cercor/bhw154 </a>en_US
dc.identifier.citationLindgren, Bergdahl J, Nyberg L. Longitudinal Evidence for Smaller Hippocampus Volume as a Vulnerability Factor for Perceived Stress. Cerebral Cortex. 2016;26(8):3527-3533en_US
dc.identifier.cristinIDFRIDAID 1375253
dc.identifier.doi10.1093/cercor/bhw154
dc.identifier.issn1047-3211
dc.identifier.issn1460-2199
dc.identifier.urihttps://hdl.handle.net/10037/10552
dc.language.isoengen_US
dc.publisherOxford University Pressen_US
dc.relation.journalCerebral Cortex
dc.rights.accessRightsopenAccessen_US
dc.subjectVDP::Medisinske Fag: 700::Klinisk medisinske fag: 750en_US
dc.subjectVDP::Medical disciplines: 700::Clinical medical disciplines: 750en_US
dc.subjecthealthy individualsen_US
dc.subjecthippocampal volumeen_US
dc.subjectmagnetic resonance imagingen_US
dc.subjectstressen_US
dc.subjectsusceptibilityen_US
dc.titleLongitudinal Evidence for Smaller Hippocampus Volume as a Vulnerability Factor for Perceived Stressen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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