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dc.contributor.authorAslaksen, Per M.
dc.contributor.authorÅsli, Ole
dc.contributor.authorØvervoll, Morten
dc.contributor.authorBjØrkedal, espen
dc.date.accessioned2017-03-20T09:56:12Z
dc.date.available2017-03-20T09:56:12Z
dc.date.issued2016-10-24
dc.description.abstractBackground: The literature on the effects of nocebo on pain is sparse. The present experimental study investigated whether suggestions of nocebo hyperalgesia modified the startle response and whether increased startle contributed to the nocebo hyperalgesic effect. Methods: A design with four groups was employed; the participants were randomized into either a placebo group, a natural history group, or into two nocebo groups. The participants in the placebo and nocebo groups received suggestions of pain decrease or pain increase, together with a placebo or nocebo cream applied to the lower arm, respectively. Heat pain was induced by a PC-controlled thermode before and after the treatment. White noise was used to elicit startle responses. Startle was assessed by measuring eye blink electromyographic responses recorded from the right orbicularis oculi muscle. Results: The results showed that nocebo suggestions increased reports of pain and startle responses. Increased startle was significantly associated with the nocebo hyperalgesic response. Conclusions: The results of the present study suggest that verbally induced expectations of increased pain engage cortical physiological defensive systems that in turn mediate the experience of increased pain.en_US
dc.description.sponsorship<br>The University of Tromsø, The Arctic University of Norway.</br> <br>The Northern Norway Health Authority to Per M. Aslaksen (grant number PFP1140-13).</br>en_US
dc.descriptionSource:<a href=http://www.sciencedirect.com/science/article/pii/S0306452216305802>http://dx.doi.org/10.1016/j.neuroscience.2016.10.040</a>en_US
dc.identifier.citationAslaksen PM, Åsli O, Øvervoll M, BjØrkedal e. Nocebo hyperalgesia and the startle response. Neuroscience. 2016;339:599-607en_US
dc.identifier.cristinIDFRIDAID 1394419
dc.identifier.doi10.1016/j.neuroscience.2016.10.040
dc.identifier.issn0306-4522
dc.identifier.issn1873-7544
dc.identifier.urihttps://hdl.handle.net/10037/10779
dc.language.isoengen_US
dc.publisherElsevier. Neuroscienceen_US
dc.relation.journalNeuroscience
dc.relation.urihttps://authors.elsevier.com/a/1U01115hTtVbYA
dc.rights.accessRightsopenAccessen_US
dc.subjectVDP::Medisinske Fag: 700en_US
dc.subjectnocebo hyperalgesiaen_US
dc.subjectplacebo analgesiaen_US
dc.subjectstartle responseen_US
dc.subjectemotionsen_US
dc.subjectpainen_US
dc.subjectexperimentalen_US
dc.titleNocebo hyperalgesia and the startle responseen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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