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dc.contributor.authorCavanagh, Jorunn Pauline
dc.contributor.authorWolden, Runa
dc.contributor.authorHeise, Philipp
dc.contributor.authorEsaiassen, Eirin
dc.contributor.authorKlingenberg, Claus
dc.contributor.authorAarag, Elizabeth
dc.date.accessioned2017-04-05T08:35:01Z
dc.date.available2017-04-05T08:35:01Z
dc.date.issued2016-09-07
dc.description.abstractThe primary aim of this study was to determine antimicrobial resistance in coagulase-negative staphylococci (CoNS) from healthy adults in the community. Healthy adults (n = 114) were swabbed on six body sites; both armpits, both knee pits and both sides of the groin. Species determination was performed using Matrix Assisted Laser Desorption Ionization – Time of Flight (MALDI-TOF) and susceptibility testing for 11 relevant antimicrobials was performed by the disc diffusion method and minimal inhibitory concentration gradient test. In total, 693 CoNS isolates were identified. Susceptibility testing was done on 386 isolates; one CoNS from each species found on each participant from the different body sites. The prevalence of antimicrobial resistance in the CoNS isolates were; erythromycin (24.6%), fusidic acid (19.9%), tetracycline (11.4%), clindamycin (7.8%), gentamicin (6.2%) and cefoxitin (4.1%). Multidrug resistance was observed in 5.2% of the isolates. Staphylococcus epidermidis and S. hominis were the first and second most prevalent species on all three body sites. We conclude that CoNS isolates from healthy adults in the community have a much lower prevalence of antimicrobial resistance than reported in nosocomial CoNS isolates. Still, we believe that levels of resistance in community CoNS should be monitored as the consumption of antimicrobials in primary care in Norway is increasing.en_US
dc.description.sponsorshipFunded by Northern Norway Regional Health Authorityen_US
dc.descriptionManuscript. Published version available in <a href=http://dx.doi.org/10.1111/apm.12591>APMIS, Volume 124, Issue 11, November 2016, pp 973–978</a>en_US
dc.identifier.citationCavanagh JP et al. Antimicrobial susceptibility and body site distribution of community isolates of coagulase-negative staphylococci. APMIS 2016; 124: 973–978.en_US
dc.identifier.cristinIDFRIDAID 1402047
dc.identifier.doi10.1111/apm.12591
dc.identifier.issn0903-4641
dc.identifier.issn1600-0463
dc.identifier.urihttps://hdl.handle.net/10037/10924
dc.language.isoengen_US
dc.publisherWileyen_US
dc.relation.journalActa Pathologica, Microbiologica et Immunologica Scandinavica (APMIS)
dc.rights.accessRightsopenAccessen_US
dc.subjectVDP::Medisinske Fag: 700en_US
dc.subjectVDP::Medical disciplines: 700en_US
dc.titleAntimicrobial susceptibility and body site distribution of community isolates of coagulase-negative staphylococcien_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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