Laursen, David RT; Nejstgaard, Camilla Hansen; Bjørkedal, Espen; Dreyer Frost, Anders; Rix Hansen, Morten; Paludan-Müller, Asger S; Prosenz, Julian; Werner, Christoph Patrick; Hrjóbjartsson, Asbjørn (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-03-06)
Background - An estimated 60% of pharmacological randomised trials use placebo control interventions to blind (i.e. mask) participants. However, standard placebos do not control for perceptible non‐therapeutic effects (i.e. side effects) of the experimental drug, which may unblind participants. Trials rarely use active placebo controls, which contain pharmacological compounds designed to mimic the ...