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dc.contributor.authorMåløy, Marthe
dc.contributor.authorMåløy, Frode
dc.contributor.authorJakobsen, Per
dc.contributor.authorBrandsdal, Bjørn Olav
dc.date.accessioned2017-09-08T06:19:49Z
dc.date.available2017-09-08T06:19:49Z
dc.date.issued2016-12-05
dc.description.abstractA model of haematopoiesis that links self-organisation with symmetric and asymmetric cell division is presented in this paper. It is assumed that all cell divisions are completely random events, and that the daughter cells resulting from symmetric and asymmetric stem cell divisions are, in general, phenotypically identical, and still, the haematopoietic system has the flexibility to self-renew, produce mature cells by differentiation, and regenerate undifferentiated and differentiated cells when necessary, due to self-organisation. As far as we know, no previous model implements symmetric and asymmetric division as the result of self-organisation. The model presented in this paper is inspired by experiments on the Drosophila germline stem cell, which imply that under normal conditions, the stem cells typically divide asymmetrically, whereas during regeneration, the rate of symmetric division increases. Moreover, the model can reproduce several of the results from experiments on female Safari cats. In particular, the model can explain why significant fluctuation in the phenotypes of haematopoietic cells was observed in some cats, when the haematopoietic system had reached normal population level after regeneration. To our knowledge, no previous model of haematopoiesis in Safari cats has captured this phenomenon.en_US
dc.descriptionSource at <a href=http://dx.doi.org/10.1016/j.jtbi.2016.11.030> http://dx.doi.org/10.1016/j.jtbi.2016.11.030 </a>en_US
dc.identifier.citationMåløy, M.R., Måløy, F., Jakobsen, P. & Brandsdal, B.O. (2017). Dynamic self-organisation of haematopoiesis and (a)symmetric cell division. <i>Journal of Theoretical Biology, 414</i>, 147-164. http://dx.doi.org/10.1016/j.jtbi.2016.11.030en_US
dc.identifier.cristinIDFRIDAID 1406417
dc.identifier.doi10.1016/j.jtbi.2016.11.030
dc.identifier.issn0022-5193
dc.identifier.issn1095-8541
dc.identifier.urihttps://hdl.handle.net/10037/11425
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.relation.ispartofMåløy, M. (2019). The nonlinear nature of biology. (Doctoral thesis). <a href=https://hdl.handle.net/10037/15214>https://hdl.handle.net/10037/15214</a>
dc.relation.journalJournal of Theoretical Biology
dc.rights.accessRightsopenAccessen_US
dc.subjectVDP::Matematikk og Naturvitenskap: 400::Matematikk: 410en_US
dc.subjectVDP::Matematikk og Naturvitenskap: 400::Basale biofag: 470::Cellebiologi: 471en_US
dc.subjectVDP::Mathematics and natural science: 400::Basic biosciences: 470::Cell biology: 471en_US
dc.subjectVDP::Mathematics and natural science: 400::Mathematics: 410en_US
dc.titleDynamic self-organisation of haematopoiesis and (a)symmetric cell divisionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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