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Gender differences in hearts subjected to decreased NO-production and elevated blood pressure
(Master thesis; Mastergradsoppgave, 2016-10-31)
Hypertension is one of the most important risk factors for heart failure in the general population. Hypertensive heart failure is associated with heart failure with preserved ejection fraction (HFpEF). Women have an increase proportion of HFpEF compared to men. Endothelial dysfunction thereby reduced NO production is proposed to play an important role in the pathophysiology of HFpEF. A suggested ...
Estrogen receptors α and β and aromatase as independent predictors for prostate cancer outcome
(Master thesis; Mastergradsoppgave, 2016-10-11)
Androgens are considered important in normal prostate physiology and prostate cancer (PCa)
pathogenesis. However, androgen-targeted treatment preventing PCa recurrence is still lacking.
This indicates additional mediators contributing to cancer development. We sought to determine the
prognostic significance of estrogen receptors, ERα and -β, and the aromatase enzyme in PCa. Tissue
microarrays ...
The creation of long-lived HPA-1a specific T-cell clones
(Master thesis; Mastergradsoppgave, 2016-08-09)
Neonatal alloimmune thrombocytopenia (NAIT) is a disease where the fetus or newborn experience pathological low levels of blood platelets. This is a potentially fatal condition. Antibodies produced by the mother, crossing the placental barrier, targeting the β3-integrins expressed on fetal platelets, drive the disease. The antibodies are initially produced by B-cells, which are dependent on T-cells ...