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dc.contributor.authorOkeke, Malachy Ifeanyi
dc.contributor.authorOkoli, Arinze Stanley
dc.contributor.authorDiaz Canova, Diana Karina
dc.contributor.authorOludotun, Taiwo G.
dc.contributor.authorTryland, Morten
dc.contributor.authorBøhn, Thomas
dc.contributor.authorMoens, Ugo
dc.date.accessioned2018-03-16T08:39:53Z
dc.date.available2018-03-16T08:39:53Z
dc.date.issued2017-10-29
dc.description.abstractModified vaccinia virus Ankara (MVA) is the vector of choice for human and veterinary applications due to its strong safety profile and immunogenicity in vivo. The use of MVA and MVA-vectored vaccines against human and animal diseases must comply with regulatory requirements as they pertain to environmental risk assessment, particularly the characterization of potential adverse effects to humans, animals and the environment. MVA and recombinant MVA are widely believed to pose low or negligible risk to ecosystem health. However, key aspects of MVA biology require further research in order to provide data needed to evaluate the potential risks that may occur due to the use of MVA and MVA-vectored vaccines. The purpose of this paper is to identify knowledge gaps in the biology of MVA and recombinant MVA that are of relevance to its hazard characterization and discuss ongoing and future experiments aimed at providing data necessary to fill in the knowledge gaps. In addition, we presented arguments for the inclusion of uncertainty analysis and experimental investigation of verifiable worst-case scenarios in the environmental risk assessment of MVA and recombinant MVA. These will contribute to improved risk assessment of MVA and recombinant MVA vaccines.en_US
dc.description.sponsorshipGenØk - Centre for Biosafety Tromsø Norway UiT - The Arctic University of Norway Erasmus Student Mobility Placement Programme IMC University of Applied Sciences Kremsen_US
dc.descriptionSource at <a href=https://doi.org/10.3390/v9110318> https://doi.org/10.3390/v9110318 </a>.en_US
dc.identifier.citationOkeke, M.I., Okoli, A.S., Diaz Canova, D.K., Offor, C., Oludotun, T.G., Tryland, M. ... Moens, U. (2017). Hazard Characterization of Modified Vaccinia Virus Ankara Vector: What Are the Knowledge Gaps? Viruses, 9(11).en_US
dc.identifier.cristinIDFRIDAID 1512645
dc.identifier.doi10.3390/v9110318
dc.identifier.issn1999-4915
dc.identifier.urihttps://hdl.handle.net/10037/12358
dc.language.isoengen_US
dc.publisherMDPIen_US
dc.relation.journalViruses
dc.rights.accessRightsopenAccessen_US
dc.subjectModified vaccinia virus Ankaraen_US
dc.subjectorthopoxvirusen_US
dc.subjecthazard characterizationen_US
dc.subjectknowledge gapsen_US
dc.subjectbiosafetyen_US
dc.subjectenvironmental risk assessmenten_US
dc.subjectuncertainty analysisen_US
dc.subjectsmallpoxen_US
dc.subjectrecombinant vaccinesen_US
dc.subjectvirus vectoren_US
dc.subjectVDP::Medisinske Fag: 700::Basale medisinske, odontologiske og veterinærmedisinske fag: 710::Medisinsk immunologi: 716en_US
dc.subjectVDP::Medical disciplines: 700::Basic medical, dental and veterinary science disciplines: 710::Medical immunology: 716en_US
dc.titleHazard Characterization of Modified Vaccinia Virus Ankara Vector: What Are the Knowledge Gaps?en_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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