Despite the recent advances in cancer therapeutics, highly aggressive cancer forms, such as glioblastoma (GBM), still have very low survival rates. The intracellular scaffold protein syntenin, comprising two postsynaptic density protein-95/discs-large/zona occludens-1 (PDZ) domains, has emerged as a novel therapeutic target in highly malignant phenotypes including GBM. Here, we report the development ...

Morphological similarities between skates of the genus Dipturus in the north-eastern Atlantic and Mediterranean have resulted in longstanding confusion, misidentification and misreporting. Current evidence indicates that the common skate is best explained two species, the flapper skate (D. intermedius) and the common blue skate (D. batis). However, some management and conservation initiatives developed ...

Lymph nodes and spleen are major organs where mammalian antigen-presenting cells (APCs) initiate and orchestrate Ag-specific immune responses. Unlike mammals, teleosts lack lymph nodes and an interesting question is whether alternative organs may serve as sites for antigen presentation in teleosts. In the current study, fluorescent ovalbumin (Ova) and CpG oligonucleotides (ODNs) injected intra-abdominally ...

The aim of this study was to provide practitioners working with trawl selectivity with general and easily understandable guidelines regarding the fish sampling effort necessary during sea trials. In particular, we focused on how many fish would need to be caught and length measured in a trawl haul in order to assess the selectivity parameters of the trawl at a designated uncertainty level. We also ...

The main challenge for the European seafood industry is to ensure sustainable production volume while adapting to climate warming. Marine fisheries mainly target 41 species which account for 80% of the seafood production in Europe. The remaining 20% comes from marine and freshwater aquaculture, which harvest mainly 5 and 11 species, respectively. European seafood production volume (2004–2014) recorded ...

During a mycology field course in Drøbak 29th August – 2nd September 2011 several interesting and some new taxa to Norway were found. Species not previously recorded in Norway include <i>Tatraea dumbirensis, Corollospora maritima, Nectriopsis candicans</i> and <i>Ombrophila juniperinella</i>. A list of 413 taxa, including records of three threatened species, is given and the ecology and distribution ...

Prosjektet har hovedfokus på havbruksnæringens lokalitetstilgang sett i lys av økt arealbehov ut fra havbruknæringens ønske om vekst. Denne veksten er ikke uproblematisk, for bruk av kystsonen utfordres av mange interesser og brukerere. De siste årene har bærekraftig utvikling av næringen hatt sterkt fokus, hvor klare miljøutfordringer relatert til påvirkning av villaks, luseproblematikk, forurensing, ...

Based on bottom trawl catches during the years 2002–2017, we present the first large-scale baseline on the spatial distribution and abundance of ice cod Arctogadus glacialis (Peters, 1874) in the fjords and on the shelf in Northeast Greenland (latitudes 70 °N–78 °N). Ice cod abundance peaked in the secluded sill fjords such as Bessel Fjord, Brede Fjord, Clavering Ø fjord system and Kong Oscar Fjord ...

Isolation of bioactive products from the marine environment is considered a very promising approach to identify new compounds that can be used for further drug development. In this work we have isolated three new compounds from the purpuroine family by mass-guided preparative HPLC; purpuroine K-M. These compounds where screened for antibacterial- and antifungal activity, antibiofilm formation and ...

Doctoral candidates are facing a diverse employment landscape that shifted significantly in the last decades, with less than 30 % of doctoral graduates working in academia or in research and development related jobs. In addition to becoming more inter-sectoral, working environments are becoming increasingly inter-national and inter-disciplinary. This development can make the employment requirements ...