• Discovery and Biosynthetic Investigation of a New Antibacterial Dehydrated Non‐Ribosomal Tripeptide 

      Wang, Shan; Fang, Qing; Lu, Zhou; Gao, Yingli; Trembleau, Laurent; Ebel, Rainer; Andersen, Jeanette Hammer; Philips, Carol; Law, Samantha; Deng, Hai (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-10-27)
      Dehydroalanine (Dha) and dehydrobutyrine (Dhb) display considerable flexibility in a variety of chemical and biological reactions. Natural products containing Dha and/or Dhb residues are often found to display diverse biological activities. While the (Z) geometry is predominant in nature, only a handful of metabolites containing (E)‐Dhb have been found thus far. Here we report discovery of a new ...
    • Signalling and bioactive metabolites from Streptomyces sp. RK44 

      Fang, Qing; Maglangit, Fleurdeliz; Wu, Linrui; Ebel, Rainer; Kyeremeh, Kwaku; Andersen, Jeanette Hammer; Annang, Frederick; Pérez-Moreno, Guiomar; Reyes, Fernando; Deng, Hai (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-01-22)
      <i>Streptomyces</i> remains one of the prolific sources of structural diversity, and a reservoir to mine for novel natural products. Continued screening for new Streptomyces strains in our laboratory led to the isolation of <i>Streptomyces</i> sp. RK44 from the underexplored areas of Kintampo waterfalls, Ghana, Africa. Preliminary screening of the metabolites from this strain resulted in the ...