• Dietary Succinate Impacts the Nutritional Metabolism, Protein Succinylation and Gut Microbiota of Zebrafish 

      Ding, Qianwen; Lu, Chenyao; Hao, Qiang; Zhang, Qingshuang; Yang, Yalin; Olsen, Rolf Erik; Ringø, Einar; Ran, Chao; Zhang, Zhen; Zhou, Zhigang (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-05-23)
      uccinate is widely used in the food and feed industry as an acidulant, flavoring additive, and antimicrobial agent. This study investigated the effects of dietary succinate on growth, energy budget, nutritional metabolism, protein succinylation, and gut microbiota composition of zebrafish. Zebrafish were fed a control-check (0% succinate) or four succinate-supplemented diets (0.05, 0.10, 0.15, and ...
    • Dietary supplementation of exopolysaccharides from Lactobacillus rhamnosus GCC-3 improved the resistance of zebrafish against spring viremia of carp virus infection 

      Xie, Mingxu; Li, Yu; Olsen, Rolf Erik; Ringø, Einar; Yang, Yalin; Zhang, Zhen; Ran, Chao; Zhou, Zhigang (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-08-05)
      Spring viremia of carp virus (SVCV) can cause high mortality of fish. The aim of this study was to investigate the effects of Lactobacillus rhamnosus GCC-3 exopolysaccharides (GCC-3 EPS) on zebrafish (Danio rerio) infected with SVCV and elucidate the underlying mechanisms. Zebrafish were fed with a control diet or diet supplemented with 0.5% and 1% of GCC-3 EPS for 2 weeks. The results showed ...
    • Effects of nuclease-treated fermentation product of Lactobacillus rhamnosus GCC-3 on growth, hepatic health and gut microbiota of zebrafish (Danio rerio) fed a high-fat diet 

      Xie, Mingxu; Li, Ming; Hao, Qiang; Olsen, Rolf-Erik; Ringø, Einar; Yang, Yalin; Zhang, Zhen; Ran, Chao; Zhou, Zhigang (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-03-12)
      Probiotics are reported to improve the nutrition, immunity, and health of fish. Nuclease can hydrolyze nucleic acids of probiotics to produce nucleotides. The present study investigated the effect of stabilized fermentation product of nuclease-treated <i>Lactobacillus rhamnosus</i> GCC-3 (GCC-3 NT) on growth, non-specific immunity, liver health, and gut microbiota of zebrafish (<i>Danio rerio</i>). ...
    • Excess DHA Induces Liver Injury via Lipid Peroxidation and Gut Microbiota-Derived Lipopolysaccharide in Zebrafish 

      Ding, Qianwen; Hao, Qiang; Zhang, Qingshuang; Yang, Yalin; Olsen, Rolf Erik; Ringø, Einar; Ran, Chao; Zhang, Zhen; Zhou, Zhigang (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-04-28)
      Being highly unsaturated, n-3 long-chain polyunsaturated fatty acids (LC-PUFAs) are prone to lipid peroxidation. In this study, zebrafish were fed with low-fat diet (LFD), high-fat diet (HFD), or 2% DHA-supplemented HFD (HFDHA2.0). To study the possible negative effects of the high level of dietary DHA, growth rates, blood chemistry, liver histology, hepatic oxidative stress, apoptosis, and ...
    • Growth performance, hepatic enzymes, and gut health status of common carp (Cyprinus carpio) in response to dietary Cetobacterium somerae fermentation product 

      Xie, Mingxu; Hao, Qiang; Olsen, Rolf Erik; Ringø, Einar; Yang, Yalin; Zhang, Zhen; Ran, Chao; Zhou, Zhigang (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-02-15)
      Intensive aquaculture practices compromise the health of fish. Probiotics especially those isolated from aquatic animals play important roles in improving fish health. The aim of the study was to evaluate the effects of stabilized fermentation product of Cetobacterium somerae (XMX-1) on the growth performance, gut and liver health of common carp. A total of 300 carps (initial weight of 2.32 ± 0.02 ...
    • Nuclease-Treated Stabilized Fermentation Product of Cetobacterium somerae Improves Growth, Non-specific Immunity, and Liver Health of Zebrafish (Danio rerio) 

      Xie, Mingxu; Hao, Qiang; Xia, Rui; Olsen, Rolf Erik; Ringø, Einar; Yang, Yalin; Zhang, Zhen; Ran, Chao; Zhou, Zhigang (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-07-06)
      High-fat diets (HFD) are harmful to fish health. Probiotics are commonly utilized to improve fish nutrition metabolism, immune response, and health. Nucleic acids of the probiotic bacterium can be hydrolyzed by nuclease to generate nucleotides. The present study aimed to evaluate the effects of stabilized fermentation product of nucleasetreated Cetobacterium somerae XMX-1 [XMX-1 (N)] on growth, ...
    • Research progress on gut health of farmers teleost fish: a viewpoint concerning the intestinal mucosal barrier and the impact of its damage 

      Zhang, Hongling; Ran, Chao; Teame, Tsegay; Ding, Qianwen; Hoseinifar, Seyed Hossein; Xie, Mingxu; Zhang, Zhen; Yang, Yalin; Olsen, Rolf Erik; Gatlin, Delbert M; Ringø, Einar; Duan, Ming; Zhou, Zhigang (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-08-05)
      The intestinal mucosal barrier plays a critical role in the maintenance of host health. In farmed teleost fish, the intestinal epithelium is challenged by a number of factors, leading to damage of the intestinal mucosal barrier. The pathogenesis of intestinal mucosal barrier damage in most farmed teleost fish has been associated with cell death, mainly including apoptosis, pyroptosis, necroptosis ...