• Peptides from the Sea Anemone Metridium senile with Modified Inhibitor Cystine Knot (ICK) Fold Inhibit Nicotinic Acetylcholine Receptors 

      Kasheverov, Igor E; Logashina, Yulia A.; Kornilov, Fedor D; Lushpa, Vladislav A; Maleeva, Ekaterina E; Korolkova, Yuliya V.; Yu, Jinpeng; Zhu, Xiaopeng; Zhangsun, Dongting; Luo, Sulan; Stensvåg, Klara; Kudryavtsev, Denis S; Mineev, Konstantin S.; Andreev, Yaroslav A. (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-12-30)
      Nicotinic acetylcholine receptors (nAChRs) play an important role in the functioning of the central and peripheral nervous systems, and other organs of living creatures. There are several subtypes of nAChRs, and almost all of them are considered as pharmacological targets in different pathological states. The crude venom of the sea anemone Metridium senile showed the ability to interact with ...