Blar i forfatter Artikler, rapporter og annet (Norges fiskerihøgskole) "Andreev, Yaroslav A."

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    • New Disulfide-Stabilized Fold Provides Sea Anemone Peptide to Exhibit Both Antimicrobial and TRPA1 Potentiating Properties 

      Logashina, Yulia A.; Solstad, Runar Gjerp; Mineev, Konstantin S.; Korolkova, Yuliya V.; Mosharova, Irina V.; Dyachenko, Igor A.; Palikov, Victor A.; Palikova, Yulia A.; Murashev, Arkadii N.; Arseniev, Alexander S.; Kozlov, Sergey A.; Stensvåg, Klara; Haug, Tor; Andreev, Yaroslav A. (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-04-29)
      A novel bioactive peptide named τ-AnmTx Ueq 12-1 (short name Ueq 12-1) was isolated and characterized from the sea anemone Urticina eques. Ueq 12-1 is unique among the variety of known sea anemone peptides in terms of its primary and spatial structure. It consists of 45 amino acids including 10 cysteine residues with an unusual distribution and represents a new group of sea anemone peptides. The 3D ...

    • Peptide from sea anemone metridium senile affects transient receptor potential ankyrin-repeat 1 (TRPA1) function and produces analgesic effect 

      Logashina, Yulia A.; Mosharova, Irina V.; Korolkova, Yulia V.; Shelukhina, Irina V; Dyachenko, Igor A.; Palikov, Victor A.; Palikova, Yulia A.; Murashev, Arkadii N.; Kozlov, Sergey A.; Stensvåg, Klara; Andreev, Yaroslav A. (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-01-11)
      The Transient Receptor Potential Ankyrin-repeat 1 (TRPA1) is an important player in pain and inflammatory pathways. It is a promising target for novel drugs development for treatment of a number of pathological states. A novel peptide producing significant potentiating effect (up to ~90%) on AITC- and diclofenac-induced currents of TRPA1 was isolated from the venom of sea anemone <i>Metridium ...

    • Peptides from the Sea Anemone Metridium senile with Modified Inhibitor Cystine Knot (ICK) Fold Inhibit Nicotinic Acetylcholine Receptors 

      Kasheverov, Igor E; Logashina, Yulia A.; Kornilov, Fedor D; Lushpa, Vladislav A; Maleeva, Ekaterina E; Korolkova, Yuliya V.; Yu, Jinpeng; Zhu, Xiaopeng; Zhangsun, Dongting; Luo, Sulan; Stensvåg, Klara; Kudryavtsev, Denis S; Mineev, Konstantin S.; Andreev, Yaroslav A. (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-12-30)
      Nicotinic acetylcholine receptors (nAChRs) play an important role in the functioning of the central and peripheral nervous systems, and other organs of living creatures. There are several subtypes of nAChRs, and almost all of them are considered as pharmacological targets in different pathological states. The crude venom of the sea anemone Metridium senile showed the ability to interact with ...